Journal articles: 'Washington (d.c.), juvenile literature' – Grafiati (2024)

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A quasi-experimental repeated measures design using a matched set of 20 test and comparison supermarkets in the Washington, D. C. and Baltimore, Md., metropolitan areas was used to evaluate a nutrition information program called “Special Diet Alert” (SDA) introduced by Giant Food, Inc. into Washington, D. C. stores in March 1981. The objective of the SDA program was to help supermarket shoppers find products for special diet needs by providing brand-specific (i.e., individual product level) shelf markers that identified products considered low or reduced in sodium, calories, cholesterol, and fat, supplemented by take-away information booklets available from a rack in the store which listed SDA brand names and specific nutrient values. Market shares of these products were tracked over the two-year evaluation period in Washington, D. C. and Baltimore stores. The pattern of differential sales trends across 16 individual food categories was complicated, but sales of shelf-marked products increased on the average 4 to 8 percent more over the two-year evaluation period in Washington, D. C. than in Baltimore, Md. stores. The average magnitude of effect attributable to SDA was modest in comparison with other factors influencing consumer purchases, highlighting the need for powerful evaluation designs to assess the effectiveness of information programs that operate in the context of many other more powerful influences. Further research is needed to determine which aspects of the SDA program were critical to its success, but one obvious difference between SDA and other in-store nutrition information programs that have been reported in the literature was the use of individual brand-specific shelf markers to deliver nutrition information to shoppers rather than prominently displayed sectional posters and detailed educational pamphlets.

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This article is organized in a way to help youth practitioners recognize the most pertinent issues faced by female juveniles and to provide help in guiding professional interactions, communication and decision-making. The guidelines discussed are suggestions for practice based on an empirical review of the literature. Recent research has identified ten characteristics of female juvenile offenders to consider when working with this population. These areas include: (a) impaired cognitive functioning, (b) low academic achievement, (c) weak language skills, (d) peer relationships, (e) onset of menarche, (f) early sexual experiences, (g) mental illness, (h) victimization (i) low self-esteem and (j) race.

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There is a long-standing belief in U.S. music education that students should learn music from other cultures. Research that incorporates elements of neuroscience, music, and culture can provide evidence teachers need to improve the design and implementation of multicultural music education curricula. The purpose of this short-form literature review is to discuss recent quantitative research in neuroscience, music, and culture to further the integration and application of neuroscientific evidence into the daily practices of music educators. This literature review includes three avenues of inquiry: (a) studies of infants’ musical perception, (b) studies from Finland highlighting the neuroplasticity of the brain, and (c) a series of experiments from the University of Washington investigating culture and the recall of music. Recommendations focus on four concepts: (a) uncovering innate musical potential, (b) developing a framework for understanding music, (c) teaching focused listening strategies, and (d) adjusting expectations in learning outcomes.

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Conversion of a general-purpose freeway into a high-occupancy-vehicle (HOV) lane is an alternative to infrastructure addition for HOV system implementation. Research indicates that lane conversion is feasible technically if sufficient HOV usage and minimal main lane congestion occur from the first day of operation. The elements required for inclusion in an implementation plan for lane conversion to HOV after technical feasibility has been determined are presented. HOV-lane marketing is meant to heighten public awareness of the purpose and operation of HOV facilities while encouraging their use. The general public, local decision makers, and the local media are important elements to include in a marketing campaign for successful HOV implementation. These elements also apply to the successful implementation of lane conversion to HOV. Four HOV lane-conversion projects are investigated: (a) Santa Monica Freeway, Los Angeles, California; (b) Dulles Toll Road, Northern Virginia; (c) Interstate 90, Seattle, Washington; and (d) Interstate 80, northern New Jersey. The Santa Monica and Dulles projects are considered failures, whereas the Interstate 80 and 90 projects are considered successful. From these case studies and the literature review, implementation elements were identified: (a) technical feasibility, (b) early public outreach, (c) strong institutional arrangements, (d) inclusion of law enforcement agencies, (e) open relationships with the media, and (f) project opening timing.

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Literature on the foreign policy behavior of economically dependent states holds that they will comply with the foreign policy preferences of the United States, particularly on cold war issues. Regional foreign policies of Mexico and Costa Rica defy this view. Despite significant economic dependence on U.S. aid and trade, both Miguel de la Madrid and Oscar Arias developed peace plans for Central America that directly countered the objectives of the Reagan policy for the area. Pressures resulting from (a) regional security threats, (b) the flow of refugees into Costa Rica and Mexico, (c) the foreign policy traditions of each country, and (d) the need to counteract the effects of dependence guided these presidents to accept the risks of a defiant foreign policy in order to satisfy local demands. Even though heavily dependent and under pressure from the U.S. government to comply with its regional foreign policy, Mexico and Costa Rica implemented policies that served their own national interests and defied Washington.

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Large adults of the caudate molpadiid Molpadia intermedia were collected from soft mud at depths of 26–28 m in East Sound, Orcas Island, Washington. In early December, both sexes spawned in the laboratory: males released occasional puffs of sperm and one female forcefully jetted eggs into the water column. The egg is 267 ± 12 μm in diameter and negatively buoyant with an orangish pink yolky cap at the animal pole which, after fertilization, develops into a coeloblastula through equal, holoblastic cleavages. The doliolaria larva bears two posterior ciliary rings and is uniformly ciliated on the anterior third of its body. The larva takes up a benthic existence soon after formation of the ciliary rings and becomes a pentactula with the protrusion of five primary tentacles. Addition of fine mud to cultures induced metamorphosis, at which time the collar of pink yolk is seen to be transferred to the region of the digestive tract. The larvae can delay metamorphosis for at least 5 d in the absence of mud. The early juvenile is transparent, and spired triradiate ossicles proliferate in the body wall. From this study and from a review of the literature, we suggest that the reproduction of the approximately 85 species of sea cucumbers in this cosmopolitan order is likely to be consistent with what we have described for M. intermedia. It is also suggested that the pink colored yolk can be used as a marker in experimental studies of development.

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Infections caused by Edwardsiella ictaluri are one of the biggest problems in the catfish industry in North America and have been reported in fishes around the world. E. ictaluri was detected in juvenile pintado Pseudoplatystoma corruscans—a Brazilian catfish—in a farm in Paraná State, Brazil; diseased animals showed ascites and neurological signs of infection, with more than 50% mortality. Exotic invasive species susceptible to this bacterium have been reported in this area. We assessed the susceptibility of pintado to E. ictaluri with experimental infection via intraperitoneal and immersion methods as well as a cohabitation experiment with Nile tilapia Oreochromis niloticus and African walking catfish Clarias gariepinus, 2 exotic invasive species. All pintados challenged by intraperitoneal and immersion routes and those cohabiting with infected C. gariepinus died within 17 d of the challenge. Mortality of Nile tilapia reached 71.42% after the intraperitoneal and 35.71% in the immersion challenges within 28 d, whereas African walking catfish showed zero mortality. Observed clinical signs were comparable to those in the farm and those described in the literature as enteric septicemia of catfish. With this study, we demonstrated the susceptibility of P. corruscans to E. ictaluri, as well as interspecies transmission of this bacterium.

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THE IDEA FOR THIS CLUSTER of work had its origins in a session of the 1996 Modern Language Association Convention in Washington, D. C., where the editors of Victorian Literature and Culture organized a panel devoted to the topic at hand: “Victorian Studies and Cultural Studies.” The panel presentations and the post-panel discussion were extremely stimulating, and it was clear that the rich topic wanted further consideration. The following selection of essays, gathered together under this journal’s special feature, the “Editors’ Topic,” is the result. Here, then, are four articles representing a range of practice — though not, by any means, the entire range of practice — in the intersecting fields of Victorian studies and cultural studies. The articles are followed by fourteen forum essays presenting an array of pressing issues, arguments, and sharp opinions centering in the relations — past, present, and potential — between Victorian studies and cultural studies. Three of the following eighteen pieces were presented (and those in shorter, nascent form) at the MLA: Mary Ellis Gibson’s article on Henry Martyn, Jane Eyre, and Missionary Biography, Kristen Leaver’s consideration of Victorian melodrama, and my brief ruminations on the concepts of “discourse” and “genre.” All the rest were commissioned for this issue of Victorian Literature and Culture.

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A systematic list of echinoderms from Malpelo Fauna and Flora Sanctuary (MFFS) was prepared, based on local sampling, literature review and identification of specimens from Museo de Historia Natural Marina de Colombia (MHNMC) and from National Museum of Natural History, Smithsonian Institution, Washington D. C. (USNM). Standard methodology for monitoring the Eastern Tropical Pacific Seascape was used in December 2006 and March 2007 to sample shallow water echinoderms (1-20 m deep). Malpelo is the richest locality of the Colombian Pacific with 84 species reported (56 % of them deep water organisms), belonging to 22 orders, 42 families and 68 genera, distributed between the surface and a depth of 5000 m. Thirty-six new records for MFFS and Colombian Pacific are reported. In Colombia the shallow water species are widely distributed in the Pacific, while deep forms only occur at Malpelo. The majority of species are mostly related to the Panamanian and Galapagos region showing a possible connectivity. This list increases knowledge on the echinoderm biodiversity from the Malpelo Island in 68 %.

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O objetivo central deste artigo é tentar compreender por meio da visão dos colaboradores de uma pequena empresa de produtos ortopédicos, as suas principais percepções, relacionadas ao compartilhamento de conhecimento organizacional. O método escolhido para a pesquisa é qualitativo com a tipologia qualitativa básica. Para a análise de resultados, foi utilizada a técnica de análise temática de Braun e Clarke. Os principais resultados encontrados demonstram que o compartilhamento de conhecimento na organização é realizado por intermédio da utilização das tecnologias de comunicações comuns ao público, assim como, com a realização frequente da técnica de brainstorming, conversas rápidas e outras estratégias para resolução de problemas conforme identificados nesta pesquisa. Referências Alavi, M., & Leidn, D. E. (2001). Knowledge management and knowledge management systems: Conceptual foundations and research issues. MIS Quarterly, 25, 107–136. Allameh, S. M.; Khozani, M. K.; Baniasadi, B. (2020) Consequences of knowledge processes in small businesses: the role of knowledge acquisition, dynamic capabilities, knowledge sharing and creativity. Int. J. Process Management and Benchmarking, Vol. 10, No. 1. Braun, V.; Clarke, V. (2012) Thematic analysis. In: Cooper, H. et al. (Eds.). APA handbook of research methods in psychology, v. 2, Research designs: Quantitative, qualitative, neuropsychological, and biological. Washington, DC: American Psychological Association, v. 2 p. 57-71. Creswell, J. W. (2007) Projeto de pesquisa: Métodos qualitativo, quantitativo e misto. 2. ed. Porto Alegre: Artmed. Cummings, J. (2003) Knowledge Sharing: A Review of the Literature. Washington D. C.: The World Bank Operations Evaluation Department. Dalkir, K. (2005) Knowledge Management in Theory and Practice. Oxford, UK: Elsevier. Drucker, P. F. (1993) Sociedade Pós-Capitalista. São Paulo: Pioneira. Gold H. A.; Malhotra, A; Segars, A, H.; (2001). Knowledge management: An Organizational Capabilities Perspective. Journal of Management Information Systems, 18 (1), 185-214. Gray, C. (2006). Absorptive capacity, knowledge management and innovation in entrepreneurial small firms. International Journal of Entrepreneurial Behavior & Research, 12 (6),345-360. Harel, R.; Schwartz, D.; Kaufmann, D. (2020) Sharing knowledge processes for promoting innovation in small businesses. European Journal of Innovation Management. ISO 30401:2018. (2018) International Organization For Standardization. Knowledge Management Systems – Requirements. Genebra: ISO. Kayas, O, G.; Wright, G. (2018) Knowledge Management and Organisational Culture. The Palgrave Handbook of Knowledge Management. ISBN 978-3-319-71434-9 (eBook). Merriam, S. B. (2009) Qualitative research: a guide to design and implementation. San Francisco: Jossey-Bass/Wiley, 2009. Morgan, G. (1980) Paradigms, metaphors, and puzzle solving in organization theory. Administrative Science Quarterly, v. 25, n. 4, p. 605-622. Na Ubon, A.; Kimble, C. (2002) Knowledge Management in Online Distance Education. Proceedings of the 3rd International Conference Networked Learning, University of Sheffield, UK, pp. 465-473. Ngah e Ibrahim (2010). The Effect of Knowledge Sharing on Organizational Performance in Small and Medium Enterprises. Santos, N.; Rados, G. J. V. (2020) Fundamentos teóricos de gestão do conhecimento. E-book. – 1. ed. – Florianópolis: Pandion, 114 p. Takeuchi, H.; Nonaka, I. (2008) Criação e dialética do conhecimento. In: Takeuchi, H.; Nonaka, I. Gestão do conhecimento. Porto Alegre: Bookman. Utami, Y.; Rofik, M.; Cahyaningtyas, N. W.; Darminto, D. P. (2021). Impact of Knowledge Sharing and Innovation on Small Business Performance. CISIS 2020: Complex, Intelligent and Software Intensive Systems pp 408-411.

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In this article, we advance a conceptual framework for the study of Teach For America (TFA) as a political and social movement with implicit and explicit ideological and political underpinnings. We argue that the second branch of TFA’s mission statement, which maintains that TFA’s greatest point of influence in public education is not in classrooms, but in its facilitation of entry into leadership positions aimed at reshaping public schooling, can be better understood in terms of the organization’s: a) infusion of “policy entrepreneurs” into educational policymaking processes; b) cultivation of powerful networks of elite interests; c) promotion of “corporate” models of managerial leadership; and, d) racial and social class identities of its corps members that facilitate entry into leadership and policy networks. Our framework is informed by the extant research literature on TFA, interview data from more than 150 alumni and corps members, and our observations of TFA’s 20th Anniversary Summit in Washington, D.C., as an illustrative case of TFA’s messaging and general orientation toward educational reform. We conclude that this framework can help illuminate under-examined political and ideological motivations behind the organization’s activities.

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Background: Wilson’s disease (WD) is an autosomal-recessive disorder of copper deposition caused by pathogenic variants in the copper-transporting ATP7B gene. There is not a clear correlation between genotype and phenotype in WD regarding symptom manifestations. This is supported by the presentation of genetically identical WD twins with phenotypic discordance and different response behavior to WD-specific therapy. Case Presentation: One of the female hom*ozygous twins (age: 26 yrs) developed writing, speaking, swallowing and walking deficits which led to in-patient examination without conclusive results but recommended genetic testing. Both sisters were tested and were heterozygous for the C.2304dupC;p(Met769Hisf*26) and the C.3207C>A;p(His1069Gln) mutation. Self-medication of the affected sibling with 450 mg D-penicillamine (DPA) did not prevent further deterioration. She developed a juvenile parkinsonian syndrome and became wheelchair-bound and anarthric. A percutaneous endoscopic gastrostomy was applied. Her asymptomatic sister helped her with her daily life. Despite the immediate increase of the DPA dose (up to 1800 mg within 3 weeks) in the severely affected patient and the initiation of DPA therapy (up to 600 mg within 2 weeks) in the asymptomatic patient after the first visit in our institution, liver function tests further deteriorated in both patients. After 2 months, the parkinsonian patient started to improve and walk again, but experienced several falls, broke her right shoulder and underwent two necessary surgical interventions. With further consequent copper elimination therapy, liver dysfunction improved in both patients, without need for orthotopic liver transplantation (LTX) in the severely affected patient. Her excellent recovery of liver and brain dysfunction was only transiently interrupted by the development of a nephrotic syndrome which disappeared after switching to Cuprior®. Unfortunately, she died from fulminant pneumonia. Conclusion: Despite identical genetic disposition, WD symptom presentations may develop differently in monozygotic twins, and they may need to be placed on a very different therapeutical regimen. The underlying gene-environment interaction is unclear so far.

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This paper discusses procedures for creating calibrated building energy simulation programs. It begins with reviews of the calibration techniques that have been reported in the previous literature and presents new hourly calibration methods including a temperature bin analysis to improve hourly x−y scatter plots, a 24-hour weather-daytype bin analysis to allow for the evaluation of hourly temperature and schedule dependent comparisons, and a 52-week bin analysis to facilitate the evaluation of long-term trends. In addition, architectural rendering is reviewed as a means of verifying the dimensions of the building envelope and external shading placement as seen by the simulation program. Several statistical methods are also presented that provide goodness-of-fit indicators, including percent difference calculations, mean bias error (MBE), and the coefficient of variation of the root mean squared error (CV(RMSE)). The procedures are applied to a case study building located in Washington, D. C. where nine months of hourly whole-building electricity data and sitespecific weather data were measured and used with the DOE-2.1D building energy simulation program to test the new techniques. Simulations that used the new calibration procedures were able to produce an hourly MBE of –0.7% and a CV(RMSE) of 23.1% which compare favorably with the most accurate hourly neural network models (Kreider and Haberl, 1994a, b).

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There has been an upward trend in gambling, particularly among older adults. With the baby-boomer generation moving toward retirement, this trend is expected to increase. Availability and social acceptability of casinos in the United States are 2 of many precipitating factors for older adults' increased enthusiasm for gambling. Noticeably absent from the literature on casino gambling is the perspective of senior social service providers (SSSPs). The present study used a cross-sectional open-ended questionnaire completed by 88 SSSPs in Washington State. The purpose of this study was to describe the SSSPs' (a) perceptions of older adults' motivations to participate in casino gambling, (b) experience with older adults who have gambling problems, (c) views and knowledge of problem gambling, and (d) perception of the need for training on gambling problems. The most prevalent reasons cited for older adults to patronize casinos were the entertainment of gambling and the desire to win money. The least prevalent reasons included peer pressure, to learn new things, and for a public smoking environment. Many respondents (42.0%) felt that their clients were aware of the risks of casino gambling. However, almost one third (29.5%) reported that their clients were largely unaware of the risks. Almost all of the respondents (85.2%) reported they had not received any training regarding problem gambling. The findings indicate the need to educate SSSPs about the potential positive and negative consequences of casino gambling.

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The literature on Congressional control of the bureaucracy has examined how members of Congress pursue strategies such as oversight, the limitation of discretion in legislation [Moe, T. (1989). The politics of bureaucratic structure. In J. E. Chubb & P. E. Peterson (Eds.), Can the Government Govern? Washington, DC: Brookings Institution); Huber, J. D., & Shipan, C. R. (2002). Deliberate discretion: The institutional foundations of bureaucratic autonomy. New York: Cambridge University Press], and the use of tools such as administrative procedures [McCubbins, M., & Schwartz, T. (1984). Congressional oversight overlooked: police patrols vs. fire alarms. American Journal of Political Science, 21(1), 165–179; McCubbins, M., Noll, R., & Weingast, B. (1987). Administrative procedures as instruments of political control. Journal of Law, Economics, and Organization, 3, 243–277] and limitation riders [MacDonald, J. A. (2010). Limitation riders and congressional influence over bureaucratic policy decisions. American Political Science Review, 104 (November), 766–782] to exert influence over executive agency decision making. One area where Congress has attempted to exert control over agency decision-making is through the legislative modification of one of the most common bureaucratic decision-making tools: benefit-cost analysis (BCA). While scholars have examined political influence in agency regulatory impact analysis BCAs for proposed rules [Shapiro, S., & Morrall III, J. F. (2012). The triumph of regulatory politics. Benefit-cost analysis and political salience. Regulation and Governance, 6(2), 189–206], there has been a lack of examination of Congressional modification of agency BCA processes to justify and protect particularized [Mayhew, D. (1974). Congress: The electoral connection. New Haven, CT: Yale University Press] infrastructure projects in their districts. This paper will examine the effect of Congressional control over agency BCA processes to secure particularized benefits by developing an in-depth case study of the Federal Contact Tower Program (FCTP) operated by the Federal Aviation Administration (FAA) that examines the political and public management implications of Congress’s limitation of the FAA’s autonomy to operate the FCTP under current benefit-cost guidance. Building upon the literature on particularized benefits and Congressional delegation, the results of this study indicate that members of Congress use BCA processes to insulate infrastructure projects in their districts by restricting the ability of agencies to optimize program effectiveness.

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At present, scholarship on matricide across many regions of the non-Western world is lacking. For instance, in Ghana, despite the intermittent, yet recurrent, availability of media reports describing matricidal acts over the past quarter century, no existing study has systematically analyzed matricidal killings in the West African nation. To contribute to the literature and extend knowledge about matricide and other forms of lethal violence in Ghana, this article presents the results of an analysis of 21 matricidal acts that occurred in Ghana from 1990 to 2016. Issues studied include demographic characteristics of assailants and victims, modus operandi, temporal and spatial aspects, as well as the motives and circ*mstances surrounding the crime. The results show that sons were substantially more likely than daughters to kill their mothers, matricide offenders were more likely to suffer from serious psychiatric disorders, matricide offenses generally occurred in the victim’s home, and all cases of matricide were characterized by massive physical force and extreme violence. Matricide offenses in Ghana differed from matricides in Western nations in four important respects: (a) none of the 21 matricides was perpetrated with a firearm, (b) in none of the cases did the offender act with a co-offender (accomplice or accessory), (c) none of the matricide offenses was perpetrated by a juvenile or adolescent offender, and (d) suspicion that the mother-victim was a maleficent witch was an important trigger in matricide perpetration.

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Background:Few patients have been described in the literature with mutations in the Lacasa Domain containing one (LACC1) gene. Its clinical presentation usually associates sustained systemic inflammation associated with chronic polyarticular erosive arthritis. Until now, there have been multiple treatments described to try to control the disease, however, they are generally unsuccessful in the long term.Objectives:Describe the clinical course of a patient as well as the different treatments usedMethods:Clinical chart reviewResults:Female 18-year-old born from a consanguineous Moroccan couple. Mother, brother and sister with similar conditions. She started at 3 years with fever, anemia, intense elevation of acute phase reactants and symmetric polyarthritis (knees, elbows, carps, shoulders, hands and ankles). Subsequent whole exome sequencing identified c.128_129delGT mutation in the LACC1/FAMIN gene. During the course of her illness, she has received treatment with oral, intravenous and infiltrated corticosteroid, methotrexate and etanercept, without getting adequate control of the disease. In 2016, she started treatment with tocilizumab (8 mg / kg every two weeks), obtaining an acceptable control of the disease (requiring periodic infiltrations every 2-3 months due to persistent arthritis). Nonetheless, in April 2019, she consulted for clinical worsening of the arthritis and laboratory test (C reactive protein 99.7 mg / L, erythrosedimentation rate 53 mm / h, leukocytes 13,500/µL and neutrophils 10,930/µL). At that time, she discontinued therapy with tocilizumab and started tofacitinib 5 mg every 12 hours with good evolution. Since its introduction, it has not required joint infiltration again and the inflammatory parameters (persistently elevated previously) have normalized.Conclusion:The jak kinasa inhibitors may be a treatment option in those patients with bad response to conventional therapy.References:[1]Rabionet R, Remesal A, Mensa-Vilaró A, Murías S, Alcobendas R, González-Roca E, Ruiz-Ortiz E, Antón J, Iglesias E, Modesto C, Comas D, Puig A, Drechsel O, Ossowski S, Yagüe J, Merino R, Estivill X, Arostegui JI. Biallelic loss-of-function LACC1/FAMIN Mutations Presenting as Rheumatoid Factor-Negative Polyarticular Juvenile Idiopathic Arthritis. Sci Rep. 2019 Mar 14;9(1):4579Disclosure of Interests:None declared

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-Sidney W. Mintz, Mats Lundahl, The Haitian economy: man, land and markets. New York: St. Martins Press, 1983. 290 pp.-Regine Altagrace Latortue, Léon-Francois Hoffmann, Essays on Haitian Literature. Washington D.C.: Three Continents Press, 1984. 184 pp.-Robert Forster, Lieutenant Howard, The Haitian journal of lieutenant Howard, York Hussars, 1796-1798. Edited with an introduction by Roger Norman Buckley. Knoxville: University of Tennessee Press, 1985. liv + 194.-David Bray, Bernardo Vega, Los Estados Unidos y Trujillo, año 1930. Santo Domingo: Fundación Cultural Dominicano, 1986. 2 vols. xi + 1120 pp.-David Bray, Bernardo Vega, Los Estados Unidos y Trujillo, año 1947. Santo Domingo: Fundación Cultural Dominicana, 1984. 2 vols. xi + 1018 pp.-David Bray, Bernardo Vega, Nazismo, fascismo y falangismo en la Republica Dominicana. Santo Domingo: Fundación Cultural Dominicana, 1985. 415 pp.-Tony Thorndike, Bruce J. Calder, The impact of intervention: The Dominican Republic during the US occupation of 1916-1924. Austin: University of Texas Press, 1984. 358 pp.-Marcella M. Little, Jacques Barbier ,The North American role in the Spanish imperial economy 1760-1819. Manchester, England, 1984: Manchester University Press. pp. 232., Allan J. Kuethe (eds)-Janette Forte, Peter Riviere, Individual and society in Guiana: a comparative study of Amerindian social organisation. Cambridge, London, New York: Cambridge University Press, 1984. 127 pp.-Stephen D. Glazier, Jay D. Dobbin, The Jombee dance of Montserrat: a study of trance ritual in the West Indies. Columbus: Ohio State University Press, 1986. 202 pp.-Robert J. Stewart, Stephen D. Glazier, Marchin' the Pilgrims home: leadership and decision-making in an Afro-Caribbean faith. Connecticut and London: Greenwood Press, 1983. xv + 165 pp.-Sidney M. Greenfield, Karen Fog Olwig, Cultural adaptation and resistance on St. John: three centuries of Afro-Caribbean life. Gainesville: University of Florida Press, 1985. xii + 226 pp.-Adam Kendon, William Washabaugh, Five fingers for survival. Ann Arbor: Karoma Publishers, Inc., 1986. xiv + 198 pp.-Evelyne T. Menard, Carnot (F. Moloen), Alors ma chére...Propos d'un musicien guadeloupéen recueillis et traduits par Marie-Céline Lafontaine. Paris: Editions Caribéennes, 1986. 159 pp.-Sally Price, Suzanne Slesin ,Caribbean style. Authors include Daniel Rozensztroch. Photographs by Gilles de Chabaneix. New York: Clarkson N. Potter, 1985. 290 pp., Stafford Cliff, Jack Berthelot (eds)-Allison Blakely, Gert Oostindie ,In het land van de overheerser. Deel II. Antillianen en Surinamers in Nederland, 1634/1667-1954. Dordrecht (Holland) and Providence RI (U.S.A.): Foris Publications, 1986. xi + 255 pp., Emy Maduro (eds)-Rosemarijn Hoefte, E. van de Boogaart ,Overzee: Nederlandse koloniale geschiedenis, 1590-1975. Haarlem: Fibula-van Dishoek, 1982. 291 pp., P.J. Drooglever et al (eds)-Frederick J. Conway, P.I. Gomes, Rural development in the Caribbean. London: C. Hurst and Company. New York: St. Martins Press, 1985. xxi + 246 pp.-Steve M. Slaby, Charles Edquist, Capitalism, socialism and technology: a comparative study of Cuba and Jamaica. London: Zed Books Ltd., 1985. xiii + 182 pp.-Joan D. Mandle, June Nash ,Women and social change in Latin America. South Hadley, Mass.: Bergin and Garvey Publishers, 1986. 372 pp., Helen Safa (eds)-Bonham C. Richardson, Michael L. Conniff, Black labor on a white canal: Panama, 1904-1981. Pittsburgh, Pa.: University of Pittsburgh Press, 1985. xv + 221 pp.-Brackette F. Williams, Stephen Glazier, Caribbean ethnicity revisited. A special edition of Ethnic Groups, International periodical of ethnic studies. New York, London, Paris, Montreaux, Tokyo: Gordon Breach Science Publishers, 1985. 164 pp.-Gert J. Oostindie, Frauke Gewecke, Die Karibik; zur Geschichte, Politik und Kultur einer Region. Frankfurt/M: Verlag Klaus Dieter Vervuert 1984. 165 pp.

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Abstract With the advent of more sensitive diagnostic techniques, we are encountering an increasing number of young patients harboring cerebral astrocytoma. The great danger in such patients is that the astrocytoma cells will undergo dedifferentiation to a higher state of malignancy. An essential question is whether the use of postoperative adjuvant radiation therapy can decrease the incidence of this event. Because a prospective, randomized study has never been carried out, it is extremely difficult to ascertain whether radiation therapy should be given to these patients. This article reviews the main retrospective clinical studies in an attempt to determine whether the addition of radiation therapy increases the length or quality of survival in patients with astrocytoma. Based on this literature review, the following tentative conclusions have been reached: (a) All reported studies are inconclusive; therefore, dogmatic statements as to whether radiation therapy should be used are not warranted. (b) One should try to obtain pathological confirmation of the precise nature of all tumor-like cerebral lesions that have been detected on neuroradiological studies. (c) Consistent with sound neurosurgical judgment, every attempt should be made to carry out a gross total removal of the hemispheric astrocytoma. (d) In the case of such a gross total surgical removal and even in its absence in the case of a juvenile pilocytic astrocytoma, radiation therapy may be withheld and the patient carefully followed for tumor recurrence. (e) In those cases where total removal cannot be accomplished, postoperative radiation therapy seems warranted. (f) Such radiation therapy should be given in a conventional fractionated schedule to a maximum of 5500 rads. The radiation therapy should not be given to the whole brain, but rather to the tumor plus a limited surrounding margin as determined by computed tomography/magnetic resonance imaging. Such a treatment regimen may reasonably be expected to lead to a 5-year survival rate of approximately 40%.

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BackgroundMONA) Multicentric Osteolysis, subcutaneous Nodulosis and Athropathy(is a rare autosomal recessive disorder caused by inactivating mutations in the matrix metallopeptidase 2 (MMP2) gene.It is manifested by osteolysis of the carpal and tarsal bones, progressive joint contractures, and fibrocollagenous nodules (1,2). In addition, there are reports of gingival hypertrophy, pigmented skin lesions, coarse face, corneal opacities, and cardiac defects (1,3). Because of joint contractures and dysmorphic features and radiological findings, it can be misdiagnosed as juvenile idiopathic arthritis and mucopolysaccharidoses respectively(4). Most affected children are apparently normal at birth with symptoms’ onset usually between six months and six years of age (5); the range is from birth to 11 years (2).To date, 51 individuals have been identified with biallelic pathogenic variants in MMP2 (3,6).Here we report a case of child MONA and galactosemia which is not known before.ObjectivesTo share this interesting extremely rare presentation and new associationMethodsAn eight year old Iraqi boy with Galactosemia at the 4th month of life presented with 4 years history of fractures of his long and short bones after trivial traumas with progressive painful deformities in hands and feet with limitation motion He has seizures, and Atrial septal defects. Intellect is normal, He had coarse facial features, hypertelorism, gum hypertrophy with high arched palate and hirsutism. Painful subcutaneous nodules involving both palms and soles (Figure 1).Figure 1.ResultsThe immunological, hematological and ultrasound were normal. The X-rays showed osteopenia, decrease in joint space and resorption of phalanges with cortical thinning and expansion of the phalangeal and metacarpal bones was a distinct finding (Figure 1). Genetic study revealed hom*ozygous MMP2 mutation.ConclusionDiagnosis of MONA Combined with galactosemia was made.References[1]Tuysuz B, Mosig R, Altun G, Sancak S, Glucksman MJ, Martignetti JA. A novel matrix metalloproteinase 2 (MMP2) terminal hemopexin domain mutation in a family with multicentric osteolysis with nodulosis and arthritis with cardiac defects. European journal of human genetics. 2009;17(5):565–72.[2]Castberg FC, Kjaergaard S, Mosig RA, Lobl M, Martignetti C, Martignetti JA, et al. Multicentric osteolysis with nodulosis and arthropathy (MONA) with cardiac malformation, mimicking polyarticular juvenile idiopathic arthritis: case report and literature review. European journal of pediatrics. 2013;172(12):1657–63.[3]Bhavani GS, Shah H, Shukla A, Gupta N, Gowrishankar K, Rao AP, et al. Clinical and mutation profile of multicentric osteolysis nodulosis and arthropathy. Am J Med Genet A. 2016 Feb;170A(2):410–7.[4]L. Kröger et al., “A novel mutation in the matrix metallopeptidase 2 coding gene associated with intrafamilial variability of multicentric osteolysis, nodulosis, and arthropathy,” Mol. Genet. genomic Med., vol. 7, no. 8, p. e802, 2019.[5]Azzollini J, Rovina D, Gervasini C, Parenti I, Fratoni A, Cubellis MV, et al. Functional characterisation of a novel mutation affecting the catalytic domain of MMP2 in siblings with multicentric osteolysis, nodulosis and arthropathy. Journal of human genetics. 2014;59(11):631–7.[6]H. Elsebaie, M. A. Mansour, S. M. Elsayed, S. Mahmoud, and T. A. El-Sobky, “Multicentric Osteolysis, Nodulosis, and Arthropathy in Two Unrelated Children with Matrix Metalloproteinase 2 Variants: Genetic-Skeletal Correlations,” 2021.Disclosure of InterestsNone declared

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The present work is a revision of corruption and the social effects it has on culture, poverty, gender and social organizations, interpreting these instances as integrative for the understanding of corruption as a phenomenon. Furthermore, the present work analyses the legal context of corruption in Paraguay. To address this, a literature review of current and topical research was carry it out, contextualizing the problem from a regional South American perspective and relating it to the efforts of the Paraguayan state with a focus on social corruption as described by various experts on the matter. In terms of the latter, the revision of the legal context of corruption in Paraguay creates an overview of the phenomenon, thus not only identifying the principal institutions, but also exposing their institutional evolution and the changes they represent in reality. Bibliografy Acemoglu, D.y Verdier, T. (2000), “The Choice between Market Failures and Corruption”. The American Economic Review, 194-211. Andvig, J. y Odd-Helge, F. (2000) “Research on Corruption: A Policy Oriented Survey”. Michelson institute y Norweigan Institute of international Affairs. Banco Mundial. (2000). Anticorruption in Transition: A Contribution to the Policy Debate. Washington, D.C: The World Bank. Biderbost, P. (2016). Guía para la Construcción de mapas de riesgos de Corrupción. Asunción: Secretaría Nacional Anticorrupción. Borda, D. & Caballero, M. (2017). Una reforma tributaria para mejorar la equidad y la recaudación. Revista Estudios Paraguayos. 107-132. Brunetti, A. & Weder, B. (1998). Explaining Corruption. University of Saarland and University of Basel. Carpenter, D. y Moss, D. (2014). Introduction. En: Carpenter, D. y Moss, D. (2014). Preventing Regulatory Capture: Special Interest Influence and How to Limit It. Nueva York, Estados Unidos: Cambridge University Press Comité Interinstitucional Técnico de Apoyo a la Implementación de la Convención Interamericana Contra la Corrupción – CITAIC. (2007). Informe de la república del Paraguay sobre las disposiciones seleccionadas para la segunda ronda de evaluación de la Convención Interamericana Contra la Corrupción para la XI Reunión del Comité de Expertos del MESISIC del 25 al 30 de junio de 2007, en Washington, D.C. Disponible en: http://www.oas.org/juridico/spanish/mec_avance_pryXI.pdf Consejo Impulsor del Sistema Nacional de Integridad – CISNI. (2003). Informe de Paraguay de la primera ronda de evaluación. Obtenido de: http://www.pj.gov.py/images/contenido/daii/cisni/unidad2/pdf/convencion.pdf De Quiróz, L. B. (1998). Dialnet. Obtenido de https://dialnet.unirioja.es/descarga/articulo/5110352.pdf Dimant, E. & Tosato, G. (2018). Causes and effects of corruption: what has past decade’s empirical research taught us? A survey. Journal of Economic Surveys. Vol. 32, No. 2, pp. 335–356. Etkin, J. (1993). La Doble Moral de las Organizaciones: Los Sistemas Perversos y la Corrupción Institucionalizada. Madrid, Editorial Mac Graw Hill. Fishman, R. y Gatti, R. (2000) “Decentralization and Corruption: Evidence Across Countries”. World Bank Policy Research Working Paper 2290. Friedrich, C. J. (1990), “Corruption Concepts in Historical Perspective.” in Political Corruption: A Handbook, Heidenheimer, A.J.; Johnston, M.; and LeVine, V.T. (eds.). New Brunswick. Transaction Publishers. f*ckuyama, F. (1995). Trust: The Social Virtues and the Creation of Prosperity. New York, Free Press. Gould, D. y Amaro-Reyes, J. (1983) “The Effect of Corruption in Administrative Gray, C. y Kaufman, D. (1998) "Corruption and Development". Finance and Develpment, N° 35. Habermas, J. (1998). ¿Aprendemos de las Catástrofes? Diagnóstico y Retrospectiva de Nuestro Breve Siglo XX. Revista Nexos y copiado de El Mercurio. Hellman, J. & Kaufmann, D. (2001). La captura del Estado en las economías en transición. Finanzas & Desarrollo, septiembre, pp.31 – 35. Hellman, J. y Kaufmann, D. (2001). La captura del Estado en las economías en transición. Finanzas & Desarrollo, septiembre, pp.31 – 35. Hellman, J. y Schankerman, M. (2000). Intervention, Corruption and Capture: The Nexus between Enterprises and the State. European Bank for Reconstruction and Development Working Paper, No. 58. Hodgson, G. y Jiang, X. (2008). La economía de la corrupción y la corrupción de la economía: una perspectiva institucionalista. Revista de Economía Institucional, vol. 10, núm. 18, pp. 55-80. Kaufmann, D. (1997) "Corruption: The Facts". World Bank Policy Working Paper. Latinobarómetro. (2018). Latinobarómetro. Obtenido de http://www.latinobarometro.org/lat.jsp Llorente y Cuenca. (Setiembre de 2016). Desarrollando Ideas D+I. Obtenido de https://www.desarrollando-ideas.com/wp-content/uploads/sites/5/2016/09/160912_DI_informe_Corrupcion_LatAm_ESP.pdf Malem Seña, J. (2000) Globalización, Comercio Internacional y Corrupción, Barcelona, Editorial Gedisa. Malem Seña, J. (2000), Globalización, Comercio Internacional y Corrupción. Barcelona, Editorial Gedisa. Mauro, P. (1995) “Corruption and Growth”. Quarterly Journal of Economics. CX, 681 Méndez Giraldo, G.; López Santana, E. (Abril de 2016). Problema Social de la Corrupción. Perspectivas desde la dinámica de sistemas. Obtenido de Editorial Udistrital: http://editorial.udistrital.edu.co/contenido/c-870.pdf Performance: Ilustrations from Developing Countries”. World Bank Working Paper N° Proud´homme, R. (1995). "The Dangers of Decentralization". The World Bank Research Observer, Vol. 10, N° 2. Reos, O. (2002). “Efectos Económicos de la Corrupción”. Documento de la División de Programas de Estado y Sociedad Civil1. Banco Interamericano de Desarrollo. Rose-Ackerman, S. (2001). Corrupción y los Gobiernos. Barcelona, Editorial Siglo XX. SENAC. (2018). Sistema de seguimiento de procesos. Asunción: SENAC. Serafini, V. (2017). Elites y captura del Estado. Paraguay: un estudio exploratorio. Asunción. Decidamos. Shleifer, A. & Vishny, R. (1993). “Corruption”. Quarterly Journal of Economics, Vol. 103, N° 3. Soto, R. (2003). Flacso Andes. Obtenido de Biblioteca Digital de Vanguardia para Investigación en Ciencias Sociales Región Andina y América Latina: www.flacsoandes.edu.ec/web/imagesFTP/1275931953.raimundo_soto.pdf Suárez, F. & Gorrochategui, N. (1998). Corrupción Organizacional: Aspectos vinculados a la Estructura de Oportunidades en Diversos Tipos de Organizaciones y Casos de Corrupción Institucionalizados. Instituto de Investigaciones Administrativas de la Facultad de Ciencias Económicas de la Universidad de Buenos Aires. Swamy, A. (1999) “Gender and Corruption”. Draft Paper, IRIS Center, University of Maryland. Swamy, A. (1999). Gender and Corruption. Draft Paper, Iris Center, University of Maryland. Sztompka, P. (1997). “Trust, distrust and the paradox of democracy”. Centro Científico de Berlín para la Investigación Social. Disponible en http://skylla.wz-berlin.de/pdf/1997/p97-003.pdf Tanzi, V. (2000) Policies, Institutions and the Dark Side of Economics. Chetenham. Edward Elgar. Tanzi, V. y Davoodi, H. (1998) “Corruption, Public Investment and Growth”. International Monetary Found Working Paper, 97-139. Transparencia Internacional. (2017). Transparency International. Obtenido de https://www.transparency.org/news/feature/corruption_perceptions_index_2017 Transparency International (2017). Corruption Perceptions Index. Berlin, August. Trujillo Arjona, A. (2002) “La Corrupción Política: Una Revisión de la Literatura”. Universidad Carlos III de Madrid. Documento de Trabajo 02-14. Trujillo Arjona, A. (2002). La Corrupción Política: Una Revisión de la Literatura. Universidad Carlos III de Madrid, Documento de Trabajo 02-14. Varese, F. (2001). “Pervasive Corruption”, Working Paper, disponible en www.colbud.hu/honesty-trust/varese/pub01.htm Weyland, K. (1998) “The Politics of Corruption in Latin America”. Journal of Democracy 9, 108-21. Zavala, R. (2013). Universidad Autónoma Nuevo León. Obtenido de Repositorio Académico Digital: http://eprints.uanl.mx/3759/1/Apuntes_sobre_la_historia_de_la_corrupcion.pdf

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The objective of this research is to present a proposal of the production function of the circular economy to contribute to the conceptual development of local productive systems. A systematic review of the literature and a critical discourse analysis were used, allowing to adjust the production functions within the LPS. The results describe how LPSs can be within into a circular productive dynamic allowing a change in the focus of the production function, which in the dominanteconomic discourse ignores possible resources and only assumes linear management models, within these systems. In conclusion, by adjusting the production function for SPLs in a dynamic circular economy, it allows the incorporation of waste as a type of secondary capital in production processes. Keywords: local productive systems, linear economy, circular economy. References [1]M. Scalone, "Introducción al enfoque de sistemas en agricultura y su aplicación para el desarrollo de sistemas de producción sostenibles". 2007. [2]M. Astudillo, "Fundamentos de Economia 1", Primera edición. México: UNAM, Instituto de Investigaciones Económicas. 2012. [3]R. Tansini, "Economía para no economistas" Uruguay: Universidad de la República, Facultad de Ciencias Sociales, 2000, 198. [4]M. A. Sánchez, "La clasificación de los factores de producción fue retomada de: Parkin, Michael. Economía. Octava edición. México: Pearson Educación, 2009, 3.[5]P. Triunfo, M. Torello, N. Berretta, L. Vicente, U. Della-Mea, M. Bergara, … and M. González, "Economía para no economistas". Montevideo: Departamento deSociología, Facultad de Ciencias Sociales, 2003. [6]C. Massad, "Economía para todos". Chile: Banco Central de Chile, 2010, 59. [7]R. Pindyck, D. Rubinfeld, "Microeconomía" Prentice Hall. 1995. [8]C.L Garcia, "Economía circular y su papel en el diseño e innovación sustentable", Libros Editorial UNIMAR, 2017. [9]V. Prieto-Sandoval, C. Jaca and M. Ormazabal. "Economía circular: Relación con la evolución del concepto de sostenibilidad y estrategias para su implementación", Memoria de Investigaciones en Ingeniería Universidad de Montevideo: Facultad de Ingeniería, 2017. [10]P. Samuelson, W. Nordhaus, "Microeconomia", 19a edición. México: Mc Graw Hill, 2017. [11]T. Winpenny, "El valor del medio ambiente. Métodos de valoración económica", Varsovia, 1995. [12]E. Neumayer, "Preserving Natural Capital in a World of Uncertainty and Scarce Financial Resources", International Journal of Sustainable Development and World Ecology 5 (1), 1998, 27-42. [13]D. Kiełczewski, "Sustainable development - the essence, interpretations, relationship with the knowledge society", Economics of sustainable development. Study materials: Szkoła Ekonomiczna, Białystok, 2010, 10-29. [14]F. Aguilera, V. Alcántara, "De la economía ambiental a la economía ecológica". Barcelona: ICARIA: FUHEM, 1994. [15]Ellen MacArthur Foundation, "Towards The Circular Economy, Economic and Business Rationale for an Accelerated Transition", Ellen MacArthur Foundation, 2013. [16]D. Pieńkowski, Kapitał naturalny w teoretycznych analizach czynników produkcji. Ekonomia i Środowisko, No. 1(21), 2002. [17]D. Pieńkowski, "Czasopismo Polskiego Stowarzyszenia Ekonomistów Środowiska i Zasobów Naturalnych", Fundacja Ekonomistów Środowiska i ZasobówNaturalnych Białystok. No. 2 (57), 2016. [18]D. Audretsch, "Knowledge Spillovers and the Geography of Innovation and Production" American Economic Review 86, 1996, 630–640. [19]F. Morales, "Desarrollo: los retos de los municipios mexicanos", Centro de Estudios Municipales Heriberto Jara, 2000. [Online]. Available: www.cedemun.org.mx. [20]Ramírez, N., Mungaray, A., Ramírez, M., and Texis, M. "Economías de escala y rendimientos crecientes: Una aplicación en microempresas mexicanas. Economía mexicana". Nueva época, 19(2), 2010, 213-230. [Online]. Available: http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S166520452010000200001&lng=es&tlng=es. 2010. [21]P. Krugman, "Urban Concentration: The Role of Increasing Returns, and Transport Costs", International Regional Science Review, 19, 1996, 5-30. [22]G. Perry, W.F. Maloney, O.S. Arias, P. Fajnzylber, A.D. Mason and J. Saavedra-Chanduvi. Informalidad: Escape y exclusión. Washington, Banco Mundial, 2007. [23]G. Garófoli, "The Italian Model of Spatial Development in the 1970s and 1980s", Industrial Change & Regional Development. Belhaven Press, London, 1991. [24]G. Garofoli, "Las experiencias de desarrollo económico local en Europa: las enseñanzas para América Latina". San José, Costa Rica: URB-AL III, 2009.

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Alsa, A. (2014). Pendekatan kualitatif dan kuantitatif serta kombinasinya dalam penelitian psikologi. Cetakan V. Yogyakarta: Pustaka Pelajar.Badan Koordinasi Keluraga Berencana Nasional (BKKBN). (2011). Kajian profil penduduk remaja (10-24 tahun): Ada apa dengan remaja. Policy Brief Puslitbang Kependudukan. Retrieved fromhttp://www.depkes.go.id/resources/download/pusdatin/infodatin/infodatin%20reproduksi%20remaja-ed.pdfBadan Pusat Statistik (BPS). (2012). Survei demografi dan kesehatan Indonesia 2012. Kesehatan Reproduksi remaja. Jakarta: Kementerian Kesehatan Jakarta. Retrieved from http://www.bkkbn.go.id/litbang/pusdu/Hasil%20Penelitian/SDKI%202012/Laporan%20Pendahuluan%20REMAJA%20SDKI%202012.pdfBadan Pusat Statistik Provinsi D.I. Yogyakarta. (2015). Statistik politik dan keamanan Provinsi Daerah Istimewa Yogyakarta. Yogyakarta: Badan Pusat Statistik.Baumrind, D., Larzele, R. E., & Owens, E. B. (2010). 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This study aims to develop an activity-based science learning model with an inquiry learning approach for early childhood that can be used to increase the sense of curiosity and scientific thinking in children aged 5-6 years. This research was conducted with research and development / R & D research methods. Data was collected through interviews, observations, questionnaires, pre-test and post-test for children. Data analysis using paired t-test. The results showed that children were interested and enthusiastic in the learning process by using a science-based learning model with the inquiry approach, Sig. (2-tailed) showing results of 0.000, so the value of 0.000 <0.05 was different from before and after the use of learning models. The results showed that: children can understand the material given by the teacher, the child is more confident and has the initiative to find answers to the teacher's questions about science material, the child's curiosity increases to examine the information provided by the teacher, the child's understanding of work processes and procedures from science learning with the inquiry approach getting better. It was concluded that an activity-based science learning model with an inquiry approach for children aged 5-6 years used an activity model with an inquiry learning approach based on children's interests and children's needs so that children's curiosity would emerge and continue to be optimally stimulated. Keywords: Inquiry approach, Learning model, Science Learning References Abdi, A. (2014). The Effect of Inquiry-based Learning Method on Students’ Academic Achievement in Science Course. Universal Journal of Educational Research, 2(1), 37–41. https://doi.org/10.13189/ujer.2014.020104 Anderson, R. D. (2002). Reforming science teaching: What research says about inquiry. Journal of Science Teacher Education, 13(1), 11–12. Bell, R. L., Smetana, L., & Binns, I. (2005). Simplifying inquiry instruction: Assessing the inquiry level of classroom activities. The Science Teacher, 72(7), 30–33. Borowske, K. (2005). Curiosity and Motivation-to-Learn (hal. 346–350). Bransford, J. D., Brown, A. L., & co*cking, R. R. (2000). How people learn: Brain, mind, experience, and school. Washington D.C.: National Academy Press. Buday, S. K., Stake, J. E., & Peterson, Z. D. (2012). Gender and The Choice of a Science Career: The Impact of Social Support and Possible Selves. Sex Roles. Diambil dari https://doi.org/10.1007/s11199-011-0015-4 Bustamance, S. A., White, J. L., & Grienfield, B. daryl. (2018). Approaches to learning and science education in Head Start: Examining bidirectionality. Early Childhood Science Quarterly. Caballero Garcia, P. A., & Diaz Rana, P. (2018). Inquiry-Based Learning: an Innovative Proposal for Early Childhood Education. Journal of Learning Styles, 11(22), 50–81. Cridge, B. J., & Cridhe, A. G. (2011). Evaluating How Universities Engage School Student with The Science: a Model Based on Analysis of The Literature. Australian University Review. Darmadi. (2017). Pengembangan Model dan Metode Pembelajaran dalam Dinamika Belajar Siswa. Yogyakarta: Deepublish. Doǧru, M., & Şeker, F. (2012). The effect of science activities on concept acquisition of age 5-6 children groups. Kuram ve Uygulamada Egitim Bilimleri, 12(SUPPL. 4), 3011–3024. Duran, M., & Dökme, I. (2016). The effect of the inquiry-based learning approach on student’s critical-thinking skills. Eurasia Journal of Mathematics, Science and Technology Education, 12(12), 2887–2908. https://doi.org/10.12973/eurasia.2016.02311a Falloon, G. (2019). Using simulations to teach young students science concepts: An Experiential Learning theoretical analysis. Computers & Education, 135(March), 138–159. https://doi.org/10.1016/j.compedu.2019.03.001 Gerli Silm, Tiitsaar, K., Pedaste, M., Zacharia, Z. C., & Papaevripidou, M. (2015). Teachers’ Readiness to Use Inquiry-based Learning: An Investigation of Teachers’ Sense of Efficacy and Attitudes toward Inquiry-based Learning. International Council of Association for Science Eduacation, 28(4), 315–325. Ginsburg, H. P., & Golbeck, S. (2004). Thoughts on the future of research on mathematics and science learning and education. Early Childhood Research Quarterly, 19(1), 190–200. Gross, C. M. (2012). Science concepts young children learn through water play. Dimensions of Early Childhood, 40(2), 3–11. Diambil dari http://www.proxy.its.virginia.edu/login?url=http://search.ebscohost.com/login.aspx?direct=true&db=ehh&AN=78303868&site=ehost-live&scope=site Guo, Y., Piasta, S. B., & Bowles, R. P. (2015). Exploring Preschool Children’s Science Content Knowledge. Early Education and Development, 26(1), 125–146. https://doi.org/10.1080/10409289.2015.968240 Halim, L., Abd Rahman, N., Zamri, R., & Mohtar, L. (2018). The roles of parents in cultivating children’s interest towards science learning and careers. Kasetsart Journal of Social Sciences, 39(2), 190–196. https://doi.org/10.1016/j.kjss.2017.05.001 Jirout, J. J. (2011). Curiosity and the Development of Question Generation Skills, (1994), 27–30. Justice, L. M., & Kaderavek, J. (2004). Embedded-explicit emergent literacy I: Background and description of approach. Language, Speech, and Hearing Services in Schools, 35, 201–211. Lind, K. K. (1998). Science in Early Childhood: Developing and Acquring Fundamental Concepts and Skills. Retrieved from ERIC (ED418777), 85. Diambil dari http://files.eric.ed.gov/fulltext/ED418777.pdf Lind, K. K. (2005). Exploring science in early childhood. (4 ed.). New York: Thomson Delmar Learning. Lindholm, M. (2018). Promoting Curiosity ? Possibilities and Pitfalls in Science Education, (1), 987–1002. Lu, S., & Liu, Y. (2017). Integrating augmented reality technology to enhance children ’ s learning in marine education, 4622(November), 525–541. https://doi.org/10.1080/13504622.2014.911247 Lukas, M. (2015). Parental Involvement of Occupational Education for Their Children. International Multidicilinary Scientific Cocerence on Social Science and Arts. Maltese, A. V, & Tai, R. H. (2011). Pipeline Persistence; Examining The Association of Educational with Earn Degrees i STEM Among US Students. Science Education. Nugent, G., Barker, B., Welsch, G., Grandgenett, N., Wu, C., & Nelson, C. (2015). A Model of Factors Contributing to STEM Learning and Career Orientation. International Journal of Science Education. Pluck, G., & Johnson, H. L. (2011). Stimulating curiosity to enhance learning. Reiser, B. J. (2004). Scaffolding complex learning: The mechanisms of structuring and problematizing student work. Journal of the Learning Sciences, 13(3), 273–304. Sackes, M., Trundle, K. C., & Flevares, L. M. (2009). Using children’s literature to teach standard-based science concepts in early years. Early Childhood Education Journal, 36(5), 415–422. https://doi.org/10.1007/s10643-009-0304-5 Walin, H., & Grady, S. O. (2016). Curiosity and Its Influence on Children ’ s Memory, 872–876. Wang, F., Kinzie, M. B., McGuire, P., & Pan, E. (2010). Applying technology to inquiry-based learning in early childhood education. Early Childhood Education Journal, 37(5), 381–389. https://doi.org/10.1007/s10643-009-0364-6 Wu, S. C., & Lin, F. L. (2016). Inquiry-based mathematics curriculum design for young children-teaching experiment and reflection. Eurasia Journal of Mathematics, Science and Technology Education, 12(4), 843–860. https://doi.org/10.12973/eurasia.2016.1233a Yahya, A., & Ismail, N. (2011). Factor in Choosing Courses and Learning Problems in Influencing The Academic Achievment of Student`s Technical Courses in Three Secondary School in The State of Negei Sembilan. Journal of Technical, Vocational & Eginereing Education. Youngquist, J., & Pataray-Ching, J. (2004). Revisiting ‘“play”’: Analyzing and articulating acts of inquiry. Early Childhood Education Journal, 31(3), 171–178.

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ABSTRAK Lingkungan rumah tangga keluarga merupakan tempat pertama kali kita menghadapi persoalan ekonomi. Ketidakpastian ekonomi di satu sisi meningkatkan permintaan akan perencanaan keuangan. Penelitian ini akan berfokus pada mencari tahu faktor-faktor mikro keluarga muslim di Indonesia yang dapat mempengaruhi keputusan investasi khususnya saham. Penelitian ini menerapkan metode kuantitatif dengan instrumen data sekunder Indonesia Family Life Survey (IFLS) gelombang 5. Teknik analisis data yang digunakan adalah analisis regresi probit, teknik analisis yang dilakukan dalam regresi probit meliputi; uji kelayakan model, analisis koefisien determinasi (R2), dan uji hipotesis. Berdasarkan hasil penelitian ditemukan bahwa variabel variabel jumlah keluarga, pinjaman, usia, dan status pernikahan tidak berpengaruh secara signifikan terhadap probabilitas kepemilikan saham. Adapun variabel pendapatan, tingkat pendidikan, jenis kelamin dan financial worship memiliki hubungan positif dan signifikan terhadap probabilitas kepemilikan saham pada keluarga muslim di Indonesia. Diharapkan penelitian ini dapat bermanfaat bagi Otoritas Jasa Keuangan dan Bursa Efek Indonesia sebagai informasi tambahan dan bahan pertimbangan dalam pembenahan kebijakan mengenai peningkatan literasi manajemen keuangan keluarga dan kesejahteraan masyarakat di Indonesia.Kata Kunci: Kepemilikan Saham, Pendapatan, Tingkat Pendidikan, Jumlah Tanggungan Keluarga, Pinjaman, Usia, Jenis Kelamin, Status Pernikahan, Financial Worship. ABSTRACTThe family home environment is the first place we face economic problems. Economic uncertainty on the one hand increases the demand for financial planning. This study will focus on finding out the micro factors of Muslim families in Indonesia that can influence investment decisions, especially stocks. This study applies quantitative methods with secondary data instruments Indonesia Family Life Survey (IFLS) wave 5 The data analysis technique used is probit regression analysis, the analysis techniques carried out in probit regression include; model feasibility test, analysis of the coefficient of determination (R2), and hypothesis testing. Based on the results of the study, it was found that the variables of family size, loan, age, and marital status did not significantly influence the probability of stock ownership. The variables of income, education level, gender and financial worship have a positive and significant relationship to the probability of stock ownership in Muslim families in Indonesia. It is hoped that this research can be useful for the Otoritas Jasa Keuangan and the Bursa Efek Indonesia as additional information and consideration in reforming policies regarding increasing literacy in family financial management and community welfare in Indonesia.Keywords: Stock Ownership, Income, Education Level, Number of Dependents in the Family, Loans, Age, Gender, Marital Status, Financial Worship. DAFTAR PUSTAKAAhmed, H. (2016). Inclusive Islamic financial planning: A conceptual framework. International Journal of Islamic and Middle Eastern Finance and Management, 9(2), 170–180. https://doi.org/10.1108/mf.2008.00934jaa.001Anshori, M., & Iswati, S. (2009). Metode penelitian kuantitatif, edisi 1. Surabaya: Airlangga University Press.Badan Pengembangan dan Pembinaan Bahasa Kemendikbud RI. (2016). Kamus Besar Bahasa Indonesia. Jakarta: Kemendikbud RI.Badan Pusat Statistik. (n.d.). Jumlah anggota rumah tangga. Retrieved from https://sirusa.bps.go.id/sirusa/index.php/variabel/8096______. (2010). Penduduk menurut wilayah dan agama yang dianut Indonesia. Retrieved from https://sp2010.bps.go.id/index.php/site/tabel?tid=321Bogan, V. L. (2008). Stock market paticipation and the internet. Journal of Financial and Quantitative Analysis, 1(43), 191–221.______. (2015). Household asset allocation, offspring education, and the sandwich generation. American Economic Review, 105(5), 611–615. https://doi.org/10.1257/aer.p20151115Brounen, D., Koedijk, K. G., & Pownall, R. A. J. (2016). Household financial planning and savings behavior. Journal of International Money and Finance, 69, 95–107. https://doi.org/10.1016/j.jimonfin.2016.06.011Brown, S., Ghosh, P., & Taylor, K. (2016). Household finances and social interaction: Bayesian analysis of household panel data. Review of Income and Wealth, 62(3), 467–488. https://doi.org/10.1111/roiw.12174Bursa Efek Indonesia. (2020). Saham. 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USA: Washington State University.Feng, X., Lu, B., Song, X., & Ma, S. (2019). Financial literacy and household finances: A bayesian two-part latent variable modeling approach. Journal of Empirical Finance, 51, 119–137. https://doi.org/10.1016/j.jempfin.2019.02.002Gao, M., & Fok, R. C. W. (2015). Demographics, family/social interaction, and household finance. Economics Letters, 136, 194–196. https://doi.org/10.1016/j.econlet.2015.09.027Ghozie, P. (2013). Make it happen!. Jakarta: PT Gramedia Pustaka Utama.Gutter, M. S., & Fontes, A. (2006). Racial differences in risky asset ownership: A two-stage model of the investment decision-making process. Journal of Financial Counseling and Planning, 17(2), 64–78.Gutter, M. S., Fox, J. J., & Montalto, C. P. (1999). Racial differences in investor decision making. Financial Services Review, 8(3), 149–162. https://doi.org/10.1016/s1057-0810(99)00040-2Halko, M., Kaustia, M., & Alanko, E. (2012). The gender effect in risky asset holdings. 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(2005). Practicing financial planning for professionals. USA: SAGE Publishing.Nadeau, R., Foucault, M., & Lewis-Beck, M. S. (2011). Assets and risk: A neglected dimension of economic voting. French Politics, 9(2), 97–119. https://doi.org/10.1057/fp.2011.5Noerhidajati, S., Purwoko, A. B., Werdaningtyas, H., Kamil, A. I., & Dartanto, T. (2020). Household financial vulnerability in Indonesia: Measurement and determinants. Economic Modelling, 96(March), 433-444. https://doi.org/10.1016/j.econmod.2020.03.028Otoritas Jasa Keuangan. (2019). Survei 2019 OJK: Indeks literasi dan inklusi keuangan meningkat. 1–6. Retrieved from https://www.ojk.go.id/id/berita-dan-kegiatan/siaran-pers/Pages/Siaran-Pers-Survei-OJK-2019-Indeks-Literasi-Dan-Inklusi-Keuangan-Meningkat.aspx______. (2021). Market update pasar modal syariah Indonesia. Retrieved from https://doi.org/10.1002/9781119196709.app1Papalia, R. D. E., Olds, S. W., & Feldman, R. D. (2009). Human Development. New York: McGraw-Hill.Rashid, N. K. 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Abstract:

У статті обґрунтовано актуальність вивчення чинників акультурації та мовної адаптації у контексті дослідження специфіки прояву прокрастинації іноземними студентами. Висвітлено особливості операціоналізації вказаних понять у сучасній науковій літературі. Вибірку дослідження склали іноземні студенти (n=41), які навчаються за освітнім рівнем «бакалавр» у двох вищих навчальних закладах України. Результати кореляційного аналізу свідчать про позитивний взаємозв’язок прокрастинації із загальним рівнем прояву стресу акультурації (r = 0.43, p<0,01), а також такими його аспектами як акультураційний страх (r = 0.46, p<0,01), сприйнята дискримінація (r = 0.37, p<0,05), почуття провини (r = 0.31, p<0,05). Вагоме значення аспектів мовної інтеграції у контексті вивчення тематики прокрастинації підтверджено зафіксованими прямими значущими кореляційними зв’язками із загальною шкалою мовної тривожності (r = 0.59, p<0,001), страхом негативної оцінки (r = 0.62, p<0,001), страхом спілкування (r = 0.62, p<0,001) та складання іспитів (r = 0.47, p<0,01). Література References Грабчак О. Особливості академічної прокрастинації студентів-першокурсників// Педагогіка і психологія професійної освіти. 2016. № 4. С. 210-218 Колтунович Т.А., Поліщук О. М. Прокрастинація – конфлікт між «важливим» і «приємним»// Young Scientist. 2017. Вип. 5, № 45. С. 211-218. Ряднова В. В., Безега Н. М., Безкоровайна І. М., Воскресенська Л. К., Пера-Васильченко А. В. Психологічні особливості процесу адаптації й організації навчання студентів-іноземців// Актуальні питання медичної (фармацевтичної) освіти іноземних громадян: проблеми та перспективи. Збірник наукових статей. 2018. С. 74-76. Balkis, M., Duru, E. (2019). Procrastination and Rational/Irrational Beliefs: A Moderated Mediation Model. Journal of Rational-Emotive & Cognitive-Behavior Therapy. doi:10.1007/s10942-019-00314-6 Berry, J. W. (2005). Acculturation: Living successfully in two cultures. International Journal of Intercultural Relations, 29(6), 697-712. http://dx.doi.org/10.1016/j.ijintrel.2005.07.013 Chowdhury, S.F., Pychyl, T.A. (2018). A critique of the construct validity of active procrastination. Personality and Individual Differences, 120, 7-12. DOI: https://doi.org/ 10.1016/j.paid.2017.08.016. DuBow, F. McCabe, E., Kaplan, G. (1979). Reactions to Crime: A Critical Review of the Literature, Unpublished report. Center for Urban Affairs, Northwestern University, Evanston, IL. Ferrari J.R., Crum K.P., Pardo M.A. (2018), Decisional procrastination: Assessing characte­rological and contextual variables around indecision. Current Psychology, 37(2), doi: 10.1007/s12144-017-9681-x. Ferrari, J. R., Johnson, J. L., McCown, W. G. (1995). The Plenum series in social/clinical psychology. Procrastination and task avoidance: Theory, research, and treatment. N.Y.: Plenum Press. doi: 10.1007/978-1-4899-0227-6 Ferrari, J. R., O'Callaghan, J., Newbegin, I. (2005). Prevalence of Procrastination in the United States, United Kingdom, and Australia: arousal and avoidance delays among adults. North American Journal of Psychology, 7(1), 1-6. Gamst-Klaussen, T., Steel, P., Svartdal, F. (2019). Procrastination and personal finances: Exploring the roles of planning and financial self-efficacy. Frontiers in Psychology, 10, 1-10. https://doi.org/10.3389/fpsyg.2019.00775 Goldin, C., Katz, L. F., Kuziemko, I. (2006), The homecoming of American college women: The reversal of the college gender gap. The Journal of Economic Perspectives, 20(4), 133-157. Haghbin, M. (2015). Conceptualization and operationalization of delay: Development and validation of the multifaceted measure of academic procrastination and the delay questionnaire. (Unpublished Ph.D. thesis). Carleton University, Ottowa, Canada. Hashemi, M., Abbasi, M. (2013). The role of the teacher in alleviating anxiety in language classes. International Journal of Applied and Basic Sciences, 4(3), 640-646. Horwitz, E. K., Horwitz, M.B., Cope, J. (1986). Foreign language classroom anxiety. The Modern Language Journal, 70(2), 125-132. Klingsieck, K. B. (2013). Procrastination: When good things don’t come to those who wait. European Psychologist, 18(1), 24-34. doi: 10.1027/1016-9040/a000138 Kornienko, A. A., Shamrova, D. P., Kvesko, S. B., Kornienko, A. A., Nikitina, Y. A., Chaplinskaya, Y. I. (2016). Adaptation Problems Experienced by International Students in Aspect of Quality Management. The European Proceedings of Social & Behavioral Sciences, 48, 358-361 doi: 10.15405/epsbs.2017.01.48 Kráľová, Z., Sorádová D. (2015). Foreign Language Learning Anxiety. In: Teaching Foreign Languages in Inclusive Education: (A teacher-trainee´s handbook), Nitra: Constantine the Philosopher University. doi: 10.17846/SEN.2015.91-100 Lee, S. (2008). Relationship between selected predictors and adjustment/acculturation stress among East Asian international students. (Doctoral dissertation). University of Kentucky, Lexington. Lindblom-Ylänne, S., Saariaho, E., Inkinen, M., Haarala-Muhonen. A., Hailikari., T (2015). Academic procrastinators, strategic delayers and something betwixt and between: An interview study. Frontline Learning Research, 3(2), 47-62. Markiewicz, K. (2018). Prokrastynacja i prokrastynatorzy. Definicja, etiologia, epidemiologia i terapia. Annales Universitatis Mariae Curie-Skłodowska, 31(3), 195-213. Markiewicz, K., Dziewulska, P. (2018). Procrastination Predictors and moderating effect of personality traits. Polskie Forum Psychologiczne, 23(3), 593-609 doi: 10.14656/ PFP20180308 Pychyl, T.A., Sirois, F. M. (2016). Procrastination, emotion regulation, and well-being. In: Procrastination, Health, and Well-Being, (pp. 163-188). Academic Press, Rorer, L. G. (1983). “Deep” RET: A reformulation of some psychodynamic explanations of procrastination. Cognitive Therapy and Research, 7, l-10. Russell, J., Rosenthal, D., Thomson, G. (2010). The international student experience: Three styles of adaptation. Higher Education, 60, 235-249 Sandhu, D. S., Asrabadi, B. R. (1994). Development of an acculturative stress scale for international students: Preliminary findings. Psychological Reports, 75(1,2), 435-448. doi: 10.2466/pr0.1994.75.1.435 Schouwenburg, H. C., Lay, C. H., Pychyl, T. A., Ferrari, J. R. (Eds.). (2004). Counseling the Procrastinator in Academic Settings. Washington, DC: American Psychological Association. doi: 10.1037/10808-000 Sirois, F.M., Pychyl, T.A. (2013). Procrastination and the Priority of Short-Term Mood Regulation: Consequences for Future Self. Social and Personality Psychology Compass, 7(2), 115-127. Steel, P. (2007). The nature of procrastination: a meta-analytic and theoretical review of quintessential selfregulatory failure. Psychological Bulletin, 133, 65–94. doi: 10.1037/0033-2909.133.1.65 Steel, P., Ferrari, J. (2013). Sex, education and procrastination: An epidemiological study of procrastinators’ characteristics from a global sample. European Journal of Personality, 27(1), 51-58. doi: 10.1002/per.1851. Tibbett, T. P., Ferrari, J. R. (2015). The portrait of the procrastinator: Risk factors and results of an indecisive personality. Personality and Individual Differences, 82, 175–184 Van Eerde, W., Klingsieck, K. B. (2018). Overcoming procrastination? A meta-analysis of intervention studies. Educational Research Review, 25, 73-85. Zhanibek, A. (2001). The relationship between language anxiety and students’ participation in foreign language classes. (Master thesis). Bilkent University, Ankara. References (translated and transliterated) Hrabchak, O. (2016). Osoblyvosti akademichnoji prokrastynaciji studentiv-pershokursnykiv [Academic procrastination features in first-year students]. Pedaghohika i Psykholohiya Profesiynoyi Osvity, 4, 210-218 Koltunovych, T.A., Polishhuk, O.M (2017). Prokrastynacija – konflikt mizh “vazhlyvym” i “pryjemnym” [Procrustination - the conflict between “important” and “pleasant”]. Young Scientist, 5 (45), 211-218. Riadnova, V.V., Bezeha, N.M., Bezkorovaina, I.M., Voskresens’ka, L.K., Pera-Vasylchenko, A.V. (2018). Psykhologhichni osoblyvosti procesu adaptaciyi i orghanizaciyi navchannia studentiv-inozemtsiv [Psychological features of the process of adaptation and organization of international students’ training]. Issues of Medical (Pharmaceutical) Education of International Citizens: Problems and Prospects. Book of abstracts (74-76). Poltava, Ukraine. Balkis, M., Duru, E. (2019). Procrastination and Rational/Irrational Beliefs: A Moderated Mediation Model. Journal of Rational-Emotive & Cognitive-Behavior Therapy. doi:10.1007/s10942-019-00314-6 Berry, J. W. (2005). Acculturation: Living successfully in two cultures. International Journal of Intercultural Relations, 29(6), 697-712. http://dx.doi.org/10.1016/j.ijintrel.2005.07.013 Chowdhury, S.F., Pychyl, T.A. (2018). A critique of the construct validity of active procrastination. Personality and Individual Differences, 120, 7-12. DOI: https://doi.org/ 10.1016/j.paid.2017.08.016. DuBow, F. McCabe, E., Kaplan, G. (1979). Reactions to Crime: A Critical Review of the Literature, Unpublished report. Center for Urban Affairs, Northwestern University, Evanston, IL. Ferrari J.R., Crum K.P., Pardo M.A. (2018), Decisional procrastination: Assessing characte­rological and contextual variables around indecision. Current Psychology, 37(2), doi: 10.1007/s12144-017-9681-x. Ferrari, J. R., Johnson, J. L., McCown, W. G. (1995). The Plenum series in social/clinical psychology. Procrastination and task avoidance: Theory, research, and treatment. N.Y.: Plenum Press. doi: 10.1007/978-1-4899-0227-6 Ferrari, J. R., O'Callaghan, J., Newbegin, I. (2005). Prevalence of Procrastination in the United States, United Kingdom, and Australia: arousal and avoidance delays among adults. North American Journal of Psychology, 7(1), 1-6. Gamst-Klaussen, T., Steel, P., Svartdal, F. (2019). Procrastination and personal finances: Exploring the roles of planning and financial self-efficacy. Frontiers in Psychology, 10, 1-10. https://doi.org/10.3389/fpsyg.2019.00775 Goldin, C., Katz, L. F., Kuziemko, I. (2006), The homecoming of American college women: The reversal of the college gender gap. The Journal of Economic Perspectives, 20(4), 133-157. Haghbin, M. (2015). Conceptualization and operationalization of delay: Development and validation of the multifaceted measure of academic procrastination and the delay questionnaire. (Unpublished Ph.D. thesis). Carleton University, Ottowa, Canada. Hashemi, M., Abbasi, M. (2013). The role of the teacher in alleviating anxiety in language classes. International Journal of Applied and Basic Sciences, 4(3), 640-646. Horwitz, E. K., Horwitz, M.B., Cope, J. (1986). Foreign language classroom anxiety. The Modern Language Journal, 70(2), 125-132. Klingsieck, K. B. (2013). Procrastination: When good things don’t come to those who wait. European Psychologist, 18(1), 24-34. doi: 10.1027/1016-9040/a000138 Kornienko, A. A., Shamrova, D. P., Kvesko, S. B., Kornienko, A. A., Nikitina, Y. A., Chaplinskaya, Y. I. (2016). Adaptation Problems Experienced by International Students in Aspect of Quality Management. The European Proceedings of Social & Behavioral Sciences, 48, 358-361 doi: 10.15405/epsbs.2017.01.48 Kráľová, Z., Sorádová D. (2015). Foreign Language Learning Anxiety. In: Teaching Foreign Languages in Inclusive Education: (A teacher-trainee´s handbook), Nitra: Constantine the Philosopher University. doi: 10.17846/SEN.2015.91-100 Lee, S. (2008). Relationship between selected predictors and adjustment/acculturation stress among East Asian international students. (Doctoral dissertation). University of Kentucky, Lexington. Lindblom-Ylänne, S., Saariaho, E., Inkinen, M., Haarala-Muhonen. A., Hailikari., T (2015). Academic procrastinators, strategic delayers and something betwixt and between: An interview study. Frontline Learning Research, 3(2), 47-62. Markiewicz, K. (2018). Prokrastynacja i prokrastynatorzy. Definicja, etiologia, epidemiologia i terapia. Annales Universitatis Mariae Curie-Skłodowska, 31(3), 195-213. Markiewicz, K., Dziewulska, P. (2018). Procrastination Predictors and moderating effect of personality traits. Polskie Forum Psychologiczne, 23(3), 593-609 doi: 10.14656/ PFP20180308 Pychyl, T.A., Sirois, F. M. (2016). Procrastination, emotion regulation, and well-being. In: Procrastination, Health, and Well-Being, (pp. 163-188). Academic Press, Rorer, L. G. (1983). “Deep” RET: A reformulation of some psychodynamic explanations of procrastination. Cognitive Therapy and Research, 7, l-10. Russell, J., Rosenthal, D., Thomson, G. (2010). The international student experience: Three styles of adaptation. Higher Education, 60, 235-249 Sandhu, D. S., Asrabadi, B. R. (1994). Development of an acculturative stress scale for international students: Preliminary findings. Psychological Reports, 75(1,2), 435-448. doi: 10.2466/pr0.1994.75.1.435 Schouwenburg, H. C., Lay, C. H., Pychyl, T. A., Ferrari, J. R. (Eds.). (2004). Counseling the Procrastinator in Academic Settings. Washington, DC: American Psychological Association. doi: 10.1037/10808-000 Sirois, F.M., Pychyl, T.A. (2013). Procrastination and the Priority of Short-Term Mood Regulation: Consequences for Future Self. Social and Personality Psychology Compass, 7(2), 115-127. Steel, P. (2007). The nature of procrastination: a meta-analytic and theoretical review of quintessential selfregulatory failure. Psychological Bulletin, 133, 65–94. doi: 10.1037/0033-2909.133.1.65 Steel, P., Ferrari, J. (2013). Sex, education and procrastination: An epidemiological study of procrastinators’ characteristics from a global sample. European Journal of Personality, 27(1), 51-58. doi: 10.1002/per.1851. Tibbett, T. P., Ferrari, J. R. (2015). The portrait of the procrastinator: Risk factors and results of an indecisive personality. Personality and Individual Differences, 82, 175–184 Van Eerde, W., Klingsieck, K. B. (2018). Overcoming procrastination? A meta-analysis of intervention studies. Educational Research Review, 25, 73-85. Zhanibek, A. (2001). The relationship between language anxiety and students’ participation in foreign language classes. (Master thesis). Bilkent University, Ankara.

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Abstract:

Abstract Introduction: Primary Myelofibrosis (PMF) and Essential Thrombocythemia (ET) are myeloproliferative neoplasms with similar genetic backgrounds. Both diseases are characterized, at the molecular level, by mutations in the genes JAK2, MPL and CALR. In addition recurring mutations is several other genes have been described in myeloid malignancies in general. Although the differential diagnosis between PMF and ET may be straight forward in most cases, there is a significant clinical and pathologic overlap between these two conditions, making the differential diagnosis difficult sometimes, mostly between early PMF and ET. With the goal of utilizing genomic information to better differentiate ET from PMF we decided to identify and compare all genomic alterations present in patients with ET and PMF, through whole exome / genome sequencing of paired granulocytes and skin. Methods: A total of 84 patients with either PMF (N=48) or ET (N=36) were analyzed. DNA was extracted from CD66b+ magnetic bead selected granulocytes (EasySep, Stem Cell Technologies) and matched skin biopsies with QiaAmp DNA Mini kit (Qiagen). Whole-exome targeted capture was carried out on 3 μg of genomic DNA, using the SureSelect Human Exome Kit 51Mb version 4 (Agilent Technologies, Inc., Santa Clara, CA, USA). The exome library was sequenced with 100 bp paired-end reads on an Illumina HiSeq2000. Somatic variants calls were generated by combining the output of Somatic Sniper (Washington University), Mutect (Broad Institute) and Pindel (Washington University). Tumor coverage was 150x and germline was 60x. The combined output of these 3 softwares was further filtered by in-house criteria in order to reduce false-positive calls (minimum coverage at both tumor/germline ≥8 reads; fraction of reads supporting alternate allele ≥5% in tumor and ≤10% in germline; ratio of allele fraction tumor:germline >2). All JAK2 and CALR mutations were validated through Sanger sequencing. Validations of other somatic mutations are under way at this point. For this work, other myeloid driver mutations were defined as mutations occurring recurrently in myeloid malignancies in the medical literature, and in this cohort of patients these mutations were present in the following genes: ASXL1, ATM, CALR, CBL, CUX1, DNMT3A, EZH2, GATA2, GNAS, IDH1, IDH2, JAK2, MPL, NRAS, SH2B3, SF3B1, STAG2, TET2, NFE2, SMC3, SUZ12, PRPF8, SRSF2, U2AF1, TP53. Fisherxs exact test was used for statistical comparisons. Results: The most common mutated genes after JAK2 and CALR were ASXL1 (n=16), TET2 (n=9) and DNMT3A (n=9). After data analysis, the patients could be divided in 7 groups based on the genomic profile: A – JAK2 mutation as the single genetic abnormality (JAK2_Single) (N=24), B – JAK2 plus other myeloid driver mutations (JAK2_Plus) (N=25), C - CALR mutation as the single genetic abnormality (CALR_Single) (N=11), D – CALR plus other myeloid driver mutations (CALR_Plus) (N=9), E – MPL mutation (N=1), F – Triple negative without other myeloid driver mutations (TN_Single) (N=8), G – No JAK2, CALR or MPL (triple negative) but with other myeloid driver mutations (TN_plus) (N=6) 1 – The presence of 3 or more total myeloid driver mutations was strongly associated with a diagnosis of PMF Table 1mut<3mut>2TE282PMF2521 P= 0.0002 2 – The presence of ASXL1 mutations was strongly associated with a diagnosis of PMF Table 2ASXL1+ASXL1-TE135PMF1533 P=0.0007 In order to validate our findings in an independent cohort of patients, we performed the same analysis using data from 2 published studies that evaluated myeloid multi-gene panels in ET and PMF (Nangalia J, NEJM 2013) (Lundberg P, Blood, 2014). We pooled together all patients with ET (N=117) and PMF (N=56) from both studies and repeated the two previous analyses, that confirmed the previous results: Table 3mut<3mut>2TE1106PMF4214P=0.0005ASXL1+ASXL1-TE4113PMF1442P=3.9E-05 Conclusions: We have demonstrated that ASXL1 mutations as well as a number of myeloid driver mutations higher than two is strongly associated with PMF. This information may be useful in the near future to improve the differential diagnosis between ET and PMF. Disclosures No relevant conflicts of interest to declare.

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Abstract:

This study aims to determine the effect of the whole language approach to the ability to read and write in English in early stages of children aged 5-6 years in one of the kindergartens in the Yogyakarta Special Region. The population in this study were 43 children who were in the age range of 5-6 years in the kindergarten. Twenty-nine participants were included in the experimental class subjects as well as the control class with posttest only control group design. Observation is a way to record data in research on early reading and writing ability. The results of Multivariate Anal- ysis of Covariance (Manova) to the data shows that 1) there is a difference in ability between the application of the whole language approach and the conventional approach to the ability to read the beginning of English; 2) there is a difference in ability between applying a whole language approach and a conventional approach to writing English beginning skills; 3) there is a difference in ability between the whole language approach and the conventional approach to the ability to read and write the beginning in English Keywords: Whole language approach, Early reading, Early writing, Early childhood Reference Abdurrahman, M. (2003). Pendidikan bagi Anak Berkesulitan Belajar. Jakarta: Rineka Cipta. Aisyah, S., Yarmi, G., & Bintoro, T. (2018). Pendekatan Whole Language dalam Pengembangan Kemampuan Membaca Permulaan Siswa Sekolah Dasar. Prosiding Seminar Nasional Pendidikan, 160–163. Alhaddad, A. S. (2014). 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Primary Innovations: A Collection of Papers, 87–94. Crystal, D. (2003). The Cambridge Encyclopedia of the English Language (second Edi). Cambridge: Cambridge University Press. Dhieni, N., Fridani, L., Muis, A., & Yarmi, G. (2014). Metode Perkembangan Bahasa. Universitas Terbuka, 1(155.4), 1–28. Dixon, J., & Sumon, T. (1996). Whole Language: An Integrated Approach to Reading and Writing. Action-Learning Manuals for Adult Literacy, 4. Doman, G. (1985). Ajaklah Balita Anda Belajar Meembaca. Bandung: CV. Yrama Widya. Fat, N. (2015). Ranking Minat Baca Pelajar Indonesia. In Minat Baca Indonesia. Flores, N. (2013). Undoing Truth in Language Teaching: Toward a Paradigm of Linguistic Aesthetics. Working Papers in Educational Linguistics (WPEL), 28(2). Folkmann, M. N. (2010). Evaluating aesthetics in design: A phenomenological approach. The MIT Press, 26(1), 40–53. Froese, V. (1991). Whole Language Practice and Theory. Boston: Allyn and Bacon.Gagne, R. M., & Briggs, L. J. (1996). Principle of Instructional Design. New York: Richard and Winston.Gardner, H. (2013). Multiple Intelegences : The Theory in ractice a Reader. New York: Basic. Goodman, K. (1986). What‟s whole in whole language. Portsmouth: NH: Heinemann. Goodman, K. S. (1986). What’s Whole in Whole Language? A Parent/Teacher Guide to Children’s Learning. Heinemann Educational Books, Inc: 70 Court St., Portsmouth, NH 03801. Hammerby, H. (1982). Synthesis in Second Language Teaching. Blane: Second Language. Hardinansyah, V. (2017). Analisis Kebutuhan pada Pengajaran Bahasa Inggris di PG-PAUD. Jurnal Pendidikan Dan Pembelajaran Anak Usia Dini, 4(2), 92–102. Jamaris, M. (2006). Perkembangan dan Pengembangan Anak Usia Dini Taman Kanak-kanak. Jakarta: Gramedia Widiasarana. Krashen, S. D. (1981). Second Language Acquisition and Second Language Learning (Wesley Longman Ltd, ed.). Addison. Krashen, S., Long, M. H., & Scarcella, R. (1979). Accounting for child-adult differences in second language rate and attainment. TESOL Quarterly, 13, 573-82. Ling-Ying, & Huang. (2014). Learning to Read with the Whole Language Approach: The Teacher’s View. Canadian Center of Science and Education : English Language Teaching, 5(7). Ling, P. (2012). The “Whole Language” Theory and Its Application to the Teaching of English Reading. Journal of Canadian Center of Science and Education, 5(3). Maulidia, C. R., Fadillah, & Miranda, D. (2019). Pengaruh Pendekatan Whole Language Terhadap Kemampuan Membaca 5-6 Tahun di TK Mawar Khatulistiwa. Program Studi Pendidikan Guru PAUD FKIP Untan Pontianak, 8(7). Mayuni, I., & Akhadiah, S. (2016). Whole Language-Based English Reading Materials. International Journal of Applied Linguistics & English Literature, 5(3). Meha, N., & Roshonah, A. F. (2014). Implementasi Whole Language Approach sebagai Pengembangan Model Pembelajaran Berbahasa Awal Anak Usia 5-6 Tahun di PAUD Non Formal. Jurnal Pendidikan, 15(1), 68–82. Moats, L. (2007). Whole language high jinks: How to Tell When “Scientifically-Based Reading Instruction” Isn’t. Washington: Thomas B. Fordham Institute. Montessori, D. M. (1991). The discovery of the Child. New York: Ballatine Books.Morrow, L. M. (1993). Literacy Development in the Early Years. United States of America: Allyn & Bacon.Munandar, A. (2013). Pemakaian Bahasa Jawa Dalam Situasi Kontak Bahasa di Daerah Istimewa Yogyakarta. Jurnal Sastra Inggris, 25(1), 92–102. Musfiroh, T. (2009). Menumbuhkembangkan Baca-Tulis Anak Usia Dini. Yogyakarta: Grasindo. Nirwana. (2015). Peningkatan Kemampuan Membaca Cepat Melalui Pendekatan Whole Language pada Siswa Kelas VI SD Negeri 246 Bulu-Bulu Kecamatan Tonra Kabupaten Bone. Jurnal Onoma: Pendidikan, Bahasa, Dan Sastra, 1(1), 79-94., 1(1), 79–94. Novitasari, D. R. (2010). Pembangunan Media Pembelajaran Bahasa Inggris Untuk Siswa Kelas 1 Pada Sekolah Dasar Negeri 15 Sragen. Sentra Penelitian Engineering Dan Edukas, Volume 2 N. Oladele, A. O., & Oladele, I. T. (2016). Effectiveness of Collaborative Strategic Reading and Whole Language Approach on Reading Comprehension Performance of Children with Learning Disabilities in Oyo State Nigeria Adetoun. International Journal on Language, Literature and Culture in Education, 3(1), 1–24. Olusegun, B. S. (2015). Constructivism Learning Theory: A Paradigm for Teaching and Learning. Journal of Research & Method in Education, 5(6), 66–70. Ortega, L. (2009). Understanding Second Language Acquisition. New York: Routledge.Otto, B. (2015). Perkembangan Bahasa Pada Anak Usia DIni (third Edit). Jakarta: Prenadamedia. Papalia, D., Old, S., & Feldman, R. (2008). Human Development (Psikologi Perkembangan). Jakarta: Kencana. Papalia, Old, & Feldman. (2009). Human Development (Psikologi Perkembangan (Kesembilan). Jakarta: Kencana. Pellini, A. PISA worldwide ranking; Indonesia’s PISA results show need to use education resources more efficiently. , (2016). Phakiti, A. (2014). Experimental Research Methods in Language Learning. London: Bloomsbury Academic. Rahim, F. (2015). Pengajaran Bahasa di Sekolah Dasar. Jakarta: PT Bumi Aksara. Routman, R. (2014). Read, write, lead: Breakthrough strategies for schoolwide literacy success. Sadtono, E. (2007). A concise history of TEFL in Indonesia. English Education in Asia: History and Policies, 205–234. Sani, R.A. (2013). Inovasi Pembelajaran. Jakarta: Bumi Aksara.Sani, Ridwan A. (2013). Inovasi Pembelajaran. Jakarta: PT Bumi Aksara. Santrock, J. W. (2016). Children (Thirteenth). New York: McGraw-Hill Education. Saracho, O. N. (2017). Literacy and language: new developments in research, theory, and practice. Early Childhood Development and Care, 3(4), 187. https://doi.org/10.1080/03004430.2017.1282235 Semiawan, C. R. (1983). Memupuk Bakat dan Minat Kreativitas Siswa Sekolah Menengah. Jakarta: Gramedia Pustaka Utama. Sikki, E. A. A., Rahman, A., Hamra, A., & Noni, N. (2013). The Competence of Primary School English Teachers in Indonesia. Journal of Education and Practice, 4(11), 139–146. Siskandar. (2009). Kurikulum Berbasis Kompetensi. Jakarta: Fasilitator. Solchan, T. W., Mulyati, Y., Syarif, M., Yunus, M., Werdiningsih, E., Pramuki, B. E., & Setiawati, L. (2008). Pendidikan Bahasa Indonesia di SD. Jakarta. Jakarta: Universitas Terbuka. Solehudin, O. (2007). Model Pembelajaran Membaca Reading Workshop: Studi Kuasi Eksperimen di SD Muhammadiyah VII Bandung (Doctoral dissertation, Universitas Pendidikan Indonesia). Universitas Pendidikan Indonesia. Suparno, S., & Yunus, M. (2007). Keterampilan Dasar Menulis. Jakarta: Universitas Terbuka. Susanto, A. (2011). Perkembangan Anak Usia Dini Pengantar dalam Berbagai Aspeknya. Jakarta: Kencana Prenada Media Group. Suyanto, K. K. E. (2010). Teaching English as foreign language to young learners. Jakarta: State University of Malang. Tarigan, D. (2001). Pendidikan Bahasa dan sastra Indonesia Kelas Rendah. Jakarta: Universitas Terbuka. Trask, R. L., & Trask, R. L. (1996). Historical linguistics. New York: Oxford University Press. Ur, P. (1996). A course in Language Teaching. Practice and Theory. Cambridge: Cambridge. University Press. Williams, A. L., McLeod, S., & McCauley, R. J. (2010). Interventions for Speech Sound Disorders in Children. Brookes Publishing Company.: PO Box 10624; Baltimore; MD 21285. Wright, P., Wallance, J., & McCAarthy, J. (2008). Aesthetics and experience-centered design. ACM Transactions on Computer-Human Interaction (TOCHI), 15(4), 18.

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Background:Since the beginning of the COVID-19 pandemic in our country, Turkey, more than two million people have been infected and more than 20,000 people have died. Although children infected less frequently and generally have a milder findings of COVID-19, the number of patients with a more severe clinical course as multisystem inflammatory syndrome in children (MIS-C) is increasing significantly. However, it has not been shown exactly how biological disease-modifying antirheumatic drug (bDMARD)s, which we frequently use in our pediatric rheumatology practice, and/or the underlying rheumatological diseases affect the clinical course of COVID-19.Objectives:Here, we aimed to reveal the outcome of COVID-19 infection in our patients with pediatric rheumatic disease and treated with bDMARDs.Methods:During the period between April 1, 2020 and December 1, 2020, the patients who received bDMARDs were evaluated at the regular outpatient clinic follow-up or by telemedicine with a maximum of 3 months interval. Clinical and demographic characteristics, COVID-19 data and outcome of these patients were retrospectively collected.Results:Out of the 436 patients treated with bDMARDs, 39 children were infected with COVID-19. The diagnosis was confirmed in 37 patients by RT-PCR (nasalpharyngeal swab) and in two by antibody test. Twenty-two (56.4%) patients were female (17 male, %43.6) and the median age of patients were 12.3 years (min-max: 1.2-20.9). The primary diagnosis of patients were as follows; 20 juvenile idiopathic arthritis (six were systemic subtype), 12 systemic autoinflammatory diseases, three vasculitis, three chronic recurrent multifocal osteomyelitis and one Sjögren’s syndrome. Prior to COVID-19 infection, 13 patients (33.3%) were using canakinumab, seven were infliximab (18%), five were adalimumab (12.8%), four were etanercept 10.2%), four were tocilizumab (10.2%), three were anakinra (7.7%), two were rituximab (5.1%), and one was tofacitinib (2.6%).Of the 39 patients, 21 had at least one COVID-19-related symptom, while 18 patients were asymptomatic. No laboratory or imaging tests was performed for asymptomatic patients and they were followed up without treatment at home isolation. Laboratory tests revealed that fourteen patients had elevated acute phase reactants, six had elevated D-dimer levels, three had lymphopenia (<1000/mm3), and three had hyperferritinemia.Hospitalization was required in 20 patients (51.3%) at median of 7-days (min-max: 3-17) and pediatric intensive care unit admission in one. Five patients developed MIS-C and one of these patients was followed up in the pediatric intensive care unit. Myocardial dysfunction was developed in this patient and he was died. The other four patients fully recovered with no remain morbidity.Conclusion:Considering the literature data and the results of our study, it is not possible to say that currently used bDMARDs worse the course of COVID-19 infection. In patients with underlying risk factors for hyperinflammation, as in one of our patients, COVID-19 may cause mortality regardless of the use of bDMARDs. Whether bDMARDs does not affect the severity of the disease, but it is still not true to say that these drugs are protective. Since cessation of bDMARDs for COVID-risk may cause exacerbation of the primary rheumatic disease, continuing with current treatments seems an appropriate approach.References:[1]FELDSTEIN LR, ROSE EB, HORWITZ SM, et al: Overcoming COVID-19 Investigators; CDC COVID-19 Response Team. Multisystem Inflammatory Syndrome in U.S. Children and Adolescents. N Engl J Med 2020; 383: 334-46.[2]MICHELENA X, BORRELL H, LÓPEZ-CORBETO M, et al. Incidence of COVID-19 in a cohort of adult and paediatric patients with rheumatic diseases treated with targeted biologic and synthetic disease-modifying anti-rheumatic drugs. Semin Arthritis Rheum 2020; 50: 564-70.Disclosure of Interests:None declared.

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Background:Familial Mediterranean fever (FMF) is a monogenic autoinflammatory hereditary disease characterized by recurrent episodes of fever with sterile peritonitis, pleural inflammation, arthritis, and/or erysipelas-like rash. Among all variants of the MEFV gene, according to the literature, five pathogenic ones have been identified, which in 75% of cases lead to the development of a typical clinical presentation: V726A, M694V, M694I, M680I, and E148Q. Among them, the M694V variant is the most common and occurs in patients with FMF in 20-65% of cases. At the same time, approximately 10 to 20% of patients meeting the diagnostic criteria for FMF do not have pathogenic variants in the MEFV gene. Despite the fact that the molecular genetic, pathogenetic and clinical features of the disease have been studied detailed, the diagnosis remains difficult due to the lack of a clear correlation between the patient’s clinical and genetic data.Objectives:To analyze the obtained genetic data of patients with pathogenic variants in the MEFV gene.Methods:The study included 103 patients who are mainly observed at the rheumatology department of the National Medical Research Center of Children’s Health of Ministry of Health of the Russian Federation in Moscow. All patients underwent analysis of the MEFV gene using Sanger sequencing with further statistical processing of the data obtained.Results:Of 103 patients, the pathogenic variant of the MEFV gene was found in 93 patients (90.3%), in 10 patients (9.7%) - the pathogenicity of the revealed variant was contradictory. Of 93 patients with the pathogenic variant of MEFV, the clinical presentation of the disease fits to FMF in 37 patients (39.6%). 11 (29.7%) of them had a mutation in M694V. Out of 37 children who met the criteria for FMF diagnosis, 15 (40.5%) children had a hom*ozygous pathogenic variant of MEVF, and 22 (59.5%) children had two mutations in a heterozygous state. 57 patients who do not have a typical clinical presentation, which is specifical for FMF are observed at the departments of rheumatology, cardiology and nephrology, 13 patients are on an outpatient observation, and 6 patients at the time of the study are over 18 years old. 8 (14%) of them had a mutation in M694V. Among 57 patients with pathogenic heterozygous variants in a, 22 patients (38.6%) are observed in the rheumatology department, among them:• Enthesitis-related arthritis - 2 patients (9%);• Systemic juvenile arthritis - 13 patients (59%);• Oligoarthritis - 5 patients (23%);• Polyarthritis- 2 patients (9%).Conclusion:Analysis of the obtained data showed that FMF is characterized by a combination of the clinical presentation and the pathogenic variant in the MEFV gene. However, the disease manifests itself not only in the hom*ozygous pathogenic variant, but also in the combination of two mutations in heterozygous. The presence of one heterozygous mutation, generally, does not lead to the development of FMF.References:[1]Konstantopoulos, A. Kanta, C. Deltas, V. Atamian, D. Mavrogianni, A.G. Tzioufas, I. Kollainis, K. Ritis, H.M. Moutsopoulos, Familial Mediterranean fever associated pyrin mutations in Greece Ann. Rheum. Dis., 62 (2003), pp. 479-481, 10.1136/ard.62.5.479.[2]Gershoni-Baruch R, Brik R, Zacks N, Shinawi M, Lidar M, Livneh A: The contribution of genotypes at the MEFV and SAA1 loci to amyloidosis and disease severity in patients with Mediterranean Fever,Seminars in Arthritis and Rheumatism,Volume 43, Issue 3, 2013, Pages 387-391familial Mediterranean fever. Arthritis Rheum 2003; 48: 1149–1155.[3]Booty MG, Chae JJ, Masters SL, et al. Familial Mediterranean fever with a single MEFV mutation: where is the second hit? Arthritis Rheum 2009; 60:185.Disclosure of Interests:None declared

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Our studies have indicated that the relative concentration of Se or Hg to As in urine and blood positively correlates with percentage of inorganic arsenic (% Inorg-As) and percentage of monomethlyarsonic acid [% MMA (V)]. We also found a negative correlation with percentage of dimethylarsinic acid [% DMA (V)] and the ratio of % DMA (V) to % MMA (V). In another study, we found that a group of proteins were significantly over expressed and conversely other groups were under-expressed in tissues in Na-As (III) treated hamsters. Introduction.Inorganic arsenic (Inorg-As) in drinking water.One of the largest public health problems at present is the drinking of water containing levels of Inorg-As that are known to be carcinogenic. At least 200 million people globally are at risk of dying because of arsenic (As) in their drinking water1-3. The chronic ingestion of Inorg-As can results in skin cancer, bladder cancer, lung cancer, and cancer of other organs1-3. The maximum contamination level (MCL) of U.S. drinking water for arsenic is 10 ug/L. The arsenic related public health problem in the U.S. is not at present anywhere near that of India4, Bangladesh4, and other countries5. Metabolism and toxicity of Inorg-As and arsenic species.Inorg-As is metabolized in the body by alternating reduction of pentavalent arsenic to trivalent form by enzymes and addition of a methyl group from S-adenosylmethionine6, 7; it is excreted mainly in urine as DMA (V)8. Inorganic arsenate [Inorg-As (V)]is biotransformed to Inorg-As (III), MMA (V), MMA (III), DMA (V), and DMA (III)6(Fig. 1). Therefore, the study of the toxicology of Inorg-As (V) involves at least these six chemical forms of arsenic. Studies reported the presence of 3+ oxidation state arsenic biotransformants [MMA (III) and DMA (III)] in human urine9and in animal tissues10. The MMA (III) and DMA (III) are more toxic than other arsenicals11, 12. In particular MMA (III) is highly toxic11, 12. In increased % MMA in urine has been recognized in arsenic toxicity13. In addition, people with a small % MMA in urine show less retention of arsenic14. Thus, the higher prevalence of toxic effects with increased % MMA in urine could be attributed to the presence of toxic MMA (III) in the tissue. Previous studies also indicated that males are more susceptible to the As related skin effects than females13, 15. A study in the U.S population reported that females excreted a lower % Inorg-As as well as % MMA, and a higher % DMA than did males16. Abbreviation: SAM, S-adenosyl-L-methionine; SAHC, S-adenosyl-L-hom*ocysteine. Differences in susceptibility to arsenic toxicity might be manifested by differences in arsenic metabolism among people. Several factors (for examples, genetic factors, sex, duration and dosage of exposure, nutritional and dietary factors, etc.) could be influence for biotransformation of Inorg-As,6, 17 and other unknown factors may also be involved. The interaction between As, Se, and Hg.The toxicity of one metal or metalloid can be dramatically modulated by the interaction with other toxic and essential elements18. Arsenic and Hg are toxic elements, and Se is required to maintain good health19. But Se is also toxic at high levels20. Recent reports point out the increased risk of squamous cell carcinoma and non-melanoma skin cancer in those treated with 200 ug/day of selenium (Nutritional Prevention of Cancer Trial in the United States)21. However, it is well known that As and Se as well as Se and Hg act as antagonists22. It was also reported that Inorg-As (III) influenced the interaction between selenite and methyl mercury23. A possible molecular link between As, Se, and Hg has been proposed by Korbas et al. (2008)24. The identifying complexes between the interaction of As and Se, Se and Hg as well as As, Se, and Hg in blood of rabbit are shown in Table 1. Influence of Se and Hg on the metabolism of Inorg-As.The studies have reported that Se supplementation decreased the As-induced toxicity25, 26. The concentrations of urinary Se expressed as ug/L were negatively correlated with urinary % Inorg-As and positively correlated with % DMA27. The study did not address the urinary creatinine adjustment27. Other researchers suggested that Se and Hg decreased As methylation28-31(Table 2). They also suggested that the synthesis of DMA from MMA might be more susceptible to inhibition by Se (IV)29 as well as by Hg (II)30,31 compared to the production of MMA from Inorg-As (III). The inhibitory effects of Se and Hg were concentration dependent28-31. The literature suggests that reduced methylation capacity with increased % MMA (V), decreased % DMA (V), or decreased ratios of % DMA to % MMA in urine is positively associated with various lesions32. Lesions include skin cancer and bladder cancer32. The results were obtained from inorganic arsenic exposed subjects32. Our concern involves the combination of low arsenic (As) and high selenium (Se) ingestion. This can inhibit methylation of arsenic to take it to a toxic level in the tissue. Dietary sources of Se and Hg.Global selenium (Se) source are vegetables in the diet. In the United States, meat and bread are the common source. Selenium deficiency in the US is rare. The US Food and Drug Administration (FDA) has found toxic levels of Se in dietary supplements, up to 200 times greater than the amount stated on the label33. The samples contained up to 40,800 ug Se per recommended serving. For the general population, the most important pathway of exposure to mercury (Hg) is ingestion of methyl mercury in foods. Fish (including tuna, a food commonly eaten by children), other seafood, and marine mammals contain the highest concentrations. The FDA has set a maximum permissible level of 1 ppm of methyl mercury in the seafood34. The people also exposed mercury via amalgams35. Proteomic study of Inorg-As (III) injury.Proteomics is a powerful tool developed to enhance the study of complex biological system36. This technique has been extensively employed to investigate the proteome response of cells to drugs and other diseases37, 38. A proteome analysis of the Na-As (III) response in cultured lung cells found in vitro oxidative stress-induced apoptosis39. However, to our knowledge, no in vivo proteomic study of Inorg-As (III) has yet been conducted to improve our understanding of the cellular proteome response to Inorg-As (III) except our preliminary study 40. Preliminary Studies: Results and DiscussionThe existing data (Fig. 1) from our laboratory and others show the complex nature of Inorg-As metabolism. For many years, the major way to study, arsenic (As) metabolism was to measure InorgAs (V), Inorg-As (III), MMA (V), and DMA (V) in urine of people chronically exposed to As in their drinking water. Our investigations demonstrated for the first time that MMA (III) and DMA (III) are found in human urine9. Also we have identified MMA (III) and DMA (III) in the tissues of mice and hamsters exposed to sodium arsenate [Na-As (V)]10, 41. Influence of Se as well as Hg on the As methyltransferase.We have reported that Se (IV) as well as mercuric chloride (HgCl2) inhibited As (III) methyltransferase and MMA (III) methyltransferase in rabbit liver cytosol. Mercuric chloride was found to be a more potent inhibitor of MMA (III) methyltransferase than As (III) methyltransferase30. These results suggested that Se and Hg decreased arsenic methylation. The inhibitory effects of Se and Hg were concentration dependent30. Influence of Se and Hg in urine and blood on the percentage of urinary As metabolites.Our human studies indicated that the ratios of the concentrations of Se or Hg to As in urine and blood were positively correlated with % Inorg-As and % MMA (V). But it negatively correlated with % DMA (V) and the ratios of % DMA (V) to % MMA (V) in urine of both males and females (unpublished data) (Table 3). These results confirmed that the inhibitory effects of Se as well as Hg for the methylation of Inorg-As in humans were concentration dependent. We also found that the concentrations of Se and Hg were negatively correlated with % Inorg-As and % MMA (V). Conversely it correlated positively with % DMA (V) and the ratios of % DMA (V) to % MMA (V) in urine of both sexes (unpublished data). These correlations were not statistically significant when urinary concentrations of Se and Hg were adjusted for urinary creatinine (Table 3). Interactions of As, Se, Hg and its relationship with methylation of arsenic are summarized in Figure 2. Sex difference distribution of arsenic species in urine.Our results indicate that females have more methylation capacity of arsenic as compared to males. In our human studies (n= 191) in Mexico, we found that females (n= 98) had lower % MMA (p<0.001) and higher % DMA (p=0.006) when compared to males (n= 93) (Fig. 3). The means ratio of % MMA (V) to % Inorg-As and % DMA (V) to %MMA (V) were also lower (p<0.05) and higher (p<0.001), respectively in females compared to males. The protein expression profiles in the tissues of hamsters exposed to Na-As (III).In our preliminary studies40, hamsters were exposed to Na-As (III) (173 pg/ml as As) in their drinking water for 6 days and control hamsters were given only the water used to make the solutions for the experimental animals. After DIGE (Two-dimensional differential in gel electrophoresis) and analysis by the DeCyder software, several protein spots were found to be over-expressed (red spot) and several were under expressed (green spot) as compared to control (Figs. 4a-c). Three proteins (one was over-expressed and two were under-expressed) of each tissue (liver and urinary bladder) were identified by LC-MS/MS (liquid chromatography-tandem mass spectrometry).DIGE in combination with LC-MS/MS is a powerful tool that may help cancer investigators to understand the molecular mechanisms of cancer progression due to Inorg-As. Propose a new researchThese results suggested that selenium (Se) as well as mercury (Hg) may influence the methylation of Inorg-As and this influence could be dependent on the concentration of Se, Hg and/or the sex of the animal. Our study also suggested that the identification and functional assignment of the expressed proteins in the tissues of Inorg-As (III) exposed animals will be useful for understanding and helping to formulate a theory dealing with the molecular events of arsenic toxicity and carcinogenicity.Therefore, it would be very useful if we could do a research study with combination of Inorg-arsenic, Se, and Hg. The new research protocol could be the following:For metabolic processing, hamsters provide a good animal model. For carcinogenesis, mouse model is well accepted. The aims of this project are: 1) To map the differential distributions of arsenic (As) metabolites/species in relation to selenium (Se) and mercury (Hg) levels in male and female hamsters and 2) To chart the protein expression profile and identify the defense proteins in mice and hamsters after As injury. Experimental hamsters (male or female) will include four groups. The first group will be treated with Na arseniteNa-As(III), the second group with Na-As (III) and Na-selenite (Na-Se (IV)], the third group with Na As (III) and methyl mercuric chloride (MeHgCl), and the final group with Na-As (III), Na-Se (IV), and MeHgci at different levels. Urine and tissue will be collected at different time periods and measured for As species using high performance liquid chromatography/inductively coupled plasma-mass spectrometry (HPLC/ICP-MS). For proteomics, mice (male and female) and hamsters (male and female) will be exposed to Na-As (III)at different levels in tap water, and control mice and hamsters will be given only the tap water. Tissue will be harvested at different time periods. TWO dimensional differential in gel electrophoresis (2D-DIGE) combined with liquid chromatography-tandem mass spectrometry (LC-MS/MS) will be employed to identify the expressed protein. In summary, we intend to extend our findings to: 1) Differential distribution of As metabolites in kidney, liver, lung, and urinary bladder of male and female hamsters exposed to Na-As (III), and combined with Na-As (III) and Na-Se (IV) and/or MeHgCl at different levels and different time periods, 2) Show the correlation of As species distribution in the tissue and urine for both male and female hamsters treated with and without Na-Se (IV) and/or MeHgCl, and 3) Show protein expression profile and identify the defense proteins in the tissues (liver, lung, and urinary bladder epithelium) in mice after arsenic injury. The significance of this study: The results of which have the following significances: (A) Since Inorg-As is a human carcinogen, understanding how its metabolism is influenced by environmental factors may help understand its toxicity and carcinogenicity, (B) The interactions between arsenic (As), selenium (Se), and mercury (Hg) are of practical significance because populations in various parts of the world are simultaneously exposed to Inorg-As & Se and/or MeHg, (C) These interactions may inhibit the biotransformation of Inorg-As (III) which could increase the amount and toxicity of Inorg-As (III) and MMA (III) in the tissues, (D) Determination of arsenic species profile in the tissues after ingestion of Inorg-As (III), Se (IV), and/or MeHg+ will help understand the tissue specific influence of Se and Hg on Inorg-As (III) metabolism, (E) Correlation of arsenic species between tissue and urine might help to understand the tissue burden of arsenic species when researchers just know the distribution of arsenic species in urine, (F) The identification of the defense proteins (over-expressed and under-expressed) in the tissues of the mouse may lead to understanding the mechanisms of inorganic arsenic injury in human. The Superfund Basic Research Program NIEHS Grant Number ES 04940 from the National Institute of Environmental Health Sciences supported this work. Additional support for the mass spectrometry analyses was provided by grants from NIWHS ES 06694, NCI CA 023074 and the BIO5 Institute of the University of Arizona. Acknowledge:The Authorwantsto dedicate this paper to the memory of Dr. H. VaskenAposhian and Dr. Mary M. Aposhian who collected urine and bloodsamples from Mexican population. The work was done under Prof. H. V. Aposhian sole supervision and with his great contribution. References NRC (National Research Council). Arsenic in Drinking Water. Update to the 1999 Arsenic in Drinking Water Report. National Academy Press, Washington, DC. 2001. Gomez-Caminero, A.; Howe, P.; Hughes, M.; Kenyon, ; Lewis, D. R.; Moore, J.; Mg, J.; Aitio, A.; Becking, G. Environmental Health Criteria 224. Arsenic and Arsenic Compounds (Second Edition). International Programme on Chemical Safety, World Health Organization. 2001. Chen, C. J.; Chen, C. W.; Wu, M.; Kuo, T. L. Cancer potential in liver, lung, bladder, and kidney due to ingested inorganic arsenic in drinking water. Br. J. Cancer. 1992, 66, 888-892. Chakraborti, D.; Rahman, M.; Paul, K.; Chowdhury, U. K.; Sengupta, M. K.; Lodh, D.; Chanda, C. R.; Saha, K. C.; Mukherjee, S. C. Arsenic calamity in the Indian subcontinent. What lessons have been learned? 2002, 58, 3-22. Nordstrom, D. K. Worldwide occurrences of arsenic in ground water. Scienc 2002, 296, 2143-2145. Aposhian, H. V.; Aposhian, M. M. Arsenic toxicology: five question Chem. Res. Toxicol. 2006, 19, 1-15. Aposhian, H. V. Enzymatic methylation of arsenic species and other new approaches to arsenic toxicity. An Rev. Pharmacol. Toxicol. 1997, 37, 397-419. Vahter, M. Variation in human metabolism of arsenic. In: Abernathy, C. O.; Calderon, R. L.; Chappell, W. R., (eds) Arsenic exposure and Health effect Elsevier Science, New York, 1999, pp 267-279. Aposhian, H. V., Gurzau, E. , Le, X. C., Gurzau, A., Healy, S. M., Lu, X., Ma, M., Yip, L., Zakharyan, R. A., Maiorino, R. M., Dart, R. C., Tircus, M. G., Gonzalez-Ramirez, D., Morgan, D. L., Avram, D., Aposhian, M. M. (2000). Occurrence of monomethylarsonous acid in urine of humans exposed to inorganic arsenic. Chem. Res. Toxicol. 13, 693-697. ; U. K.; Zakharyan, R. A.; Hernandez, A.; Avram, M.D.; Kopplin, M. J.; Aposhian, H. V. Glutathione-S-transferase-omega [MMA (V) reductase] knockout mice: Enzyme and arsenic species concentrations in tissues after arsenate administration. Toxicol. Appl. Pharmacol. 2006, 216, 446-457. Styblo, M.; Del Razo, L. M.; Vega, L.; Germolec, D. R.; LeCluyse, E. L.; Hamilton, G. A.; Reed, W.; Wang, C.; Cullen, W. R.; Thomas, D.J. Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells. A Toxicol., 2000, 74, 289-299. Petrick, J. S.; Jagadish, B.; Mash, E. A.; Aposhian, H. V. Monomethylarsonous acid (MMAIII) and arsenite: LD50 in hamsters and in vitro inhibition of pyruvate dehydrogenase. Ch Res. Toxicol. 2001, 14, 651-656. Lindberg, A. L.; Rahman, M.; Persson, L. A.; Vahter, M. The risk of arsenic induced skin lesions in Bangladeshi men and women is affected by arsenic metabolism and the age at first exposure. Appl. Pharmacol. 2008, 230, 9-16. Vahter, M. Mechanisms of arsenic biotransformation. Toxicolog 2002, 181-182, 211-217. Chen, Y. C.; Guo, Y. L.; Su, H. J.; Hsueh, Y. M.; Smith, T. J.; Ryan, L. M.; Lee, M. S.; Chao, S. C.; Lee, J. Y.; Christiani, D. C. Arsenic methylation and skin cancer risk in southwestern Taiwan. Occup. Environ. Med. 2003, 45, 241-248. Steinmaus, C.; Carrigan, K.; Kalman, D.; Atallah, R.; Yuan, Y.; Smith, A.H. Dietary intake and arsenic methylation in a U.S. population. Health Perspect. 2005, 113, 1153-1159. Tseng, C. H. A review on environmental factors regulating arsenic methylation in humans. Appl. Pharmacol. 2009, 235, 338-350. Goyer, R. A. Factors influencing metal toxicity. In: Goyer, R. A.; Klaassen, C. D.; Waalkes, M. P. (eds) Metal toxicolog Academic Press, San Diego, 1995, pp 31-45. Wilber, C. G. Toxicology of selenium. Toxicol. 1980, 17, 171-230. Skerfving, S. Interaction between selenium and methylmercury. Environ. Health Persp 1978, 25, 57-65. Duffield-Lillico, A. J.; Slate, E. H.; Reid, M. E.; Turnbull, B. W.; Wilkins, P. A.; Combs, G. F.; Kim Park, Jr. H.; Gross, E. G.; Graham, G. F.; Stratton, M. S.; Marshall, J. R.; Clark, L. C. Selenium supplementation and secondary prevention of nonmelanoma skin cancer in a randomized trial. Natl. Cancer Inst. 2003, 95, 1477-1481. Gailer, J. Arsenic-selenium and mercury-selenium bonds in biology. Chem. Rev. 2007, 251, 234-254. Alexander, J. The influence of arsenite on the interaction between selenite and methyl mercury. Dev. Toxicol. Environ. Sci. 1980, 8, 585-590. Korbas, M.; Percy, J.; Gailer, J.; George, G. N. A possible molecular link between the toxicological effects of arsenic, selenium and methyl mercury: methyl mercury (II) selenobis (S glutathionyl) arsenic (III). J. Biol. Inorg. Chem. 2008, 13, 461-470. Yang, ; Wang, W.; Hou, S.; Peterson, P. J.; Williams, W. P. Effect of selenium supplementation on arsenism: an intervention trial in Inner Mongolia. Environ. Geochem. Health. 2002, 24, 359-374. Verret, W. J.; Chen, Y.; Ahmed, A.; Islam, T.; Parvez, F.; Kibriya, M. G.; Graziano, J. H.; Ahsan, H. Effects of vitamin E and selenium on arsenic-induced skin lesions. Occup. Environ. Med. 2005, 47, 1026-1035. Hsueh, Y. M.; Ko, Y. F.; Huang, Y. K.; Chen, H. W.; Chiou, H. Y.; Huang, Y. L.; Yang, M. ; Chen, C. J. Determinants of inorganic arsenic methylation capability among residents of the Lanyang Basin, Taiwan: arsenic and selenium exposure and alcohol consumption. Toxicol. Lett. 2003, 137, 49-63. Kenyon, E. M.; Hughes, M. K.; Levander, 0. Influence of dietary selenium on the disposition of arsenate in the female B6C3F1 mouse. J. Toxicol. Environ. Health. 1997, 51, 279-299. Styblo, M.; Thomas, D, J. Selenium modifies the metabolism and toxicity of arsenic in primary rat hepatocytes. Toxicol Appl. Pharmacol. 2001, 172, 52-61. Zakharyan, R.; Wu, Y.; Bogdan, G. M.; Aposhian, H. V. Enzymatic methylation of arsenic compounds: assay, partial purification, and properties of arsenite methyltransferase and monomethylarsonic acid methyltransferase of rabbit liver. Res. Toxicol.1995, 8, 1029-1038. Styblo, M.; Delnomdedieu, M.; Thomas, D. J. Mono- and dimethylation of arsenic in rat liver cytosol in vitro. -Biol. Interact. 1996, 99, 147-164. Tseng C. H. Arsenic methylation, urinary arsenic metabolites and human diseases: current perspective. J. Environ. Sci. Health Part C. 2007, 25, 1-22. FDA (The US Food and Drug administration). (2008). Hazardous levels of selenium in samples of "Total Body Formula" and "Total Body Mega Formula”. FDA Ne 2008. ATSDR (Agency for Toxic Substances and Disease Registry). Toxicological profile for mercury (CAS # 7439-97-6). Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service. 1999. Dye, B. A.; Schober, S. E.; Dillon, C. F.; Jones, R. L.; Fryar, C.; McDowell, M.; Sinks, T. H. Urinary mercury concentrations associated with dental restorations in adults women aged 16-49 years: United States, 1999-2000. O Environ. Med. 2005, 62, 368-375. Lau, A. T.; He, Q. Y.; Chiu, J. F. Proteomic technology and its biomedical applications. A Biophys. Sin. 2003, 35, 965-975. Jungblut, P. R.; Zimny-Arndt, U.; Zeindl-Eberhart, E.; Stulik, J.; Koupilova, K.; Pleissner, K. P.; Otto, A.; Muller, E. C.; Sokolowska-Kohler, W.; Grabher, G.; Stoffler, G. Proteomics in human disease: cancer, heart and infectious diseases. Electrophoresis. 1999, 20, 2100-2110. Hanash, S. 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Background:Migration of Romanians to work abroad began after 1990 with the aim to provide a better income and life for their family. Current studies show that the migration of one parent or both, even when it is temporary, produces negative long-term effects on the health and psychosocial evolution of the children affected. Children and adolescents exposed to chronic stress due to migration, misunderstandings between the parents, alcoholism, violence, divorce of the parents etc., present an increased risk of illness. More and more data from the literature suggest that prolonged stress and depression induces inadequate cortisol along with norepinephrine secretion, increased synthesis of proinflammatory cytokines, which are the basis for autoimmune pathologies, such as chronic arthritis.Objectives:Given the extended phenomenon of migration from Romania and the increase in the cases with autoimmune pathology in children and adolescents, we aimed to evaluate the association between the disorders related to the permanent stress induced by the parental migration abroad and the risk of developing arthritis during childhood.Methods:The study included 201 children and adolescents aged 13.4 ± 3.7 years, who were in evidence of an outpatient health unit, from 2016-2019. These cases were included in a chronic disease registry with the diagnosis of Juvenile Idiopathic Arthritis (JIA), established by a pediatric rheumatologist.For the initial evaluation, we used a questionnaire that included the socio-demographic data. In comparison, we studied 40 healthy children (control group). The family drawing test was used for patients between 5 and 16 years of age to identify possible conflicts with certain family members, to assess the emotional and psychological maturity of the child or adolescent, and to find out if are there any problems at home.Results:At the end of the study, only 181 (90%) of the eligible patients completed the questionnaire and the family drawing test. Demographic data showed that patients from rural areas predominated (71.8%), compared to 28.2% from urban areas.In terms of sex, 52.5% were male, compared to 47.5% female. Family history (mother, father, sister, brother, grandfather, aunt, uncle) of autoimmune disease was encountered in 28.1% of patients, as follows: spondylarthritis in 9.4% cases, rheumatoid arthritis in 8.8% cases, JIA in 3.9% cases and other autoimmune diseases (Systemic Lupus Erythematosus, Scleroderma, Diabetes, Asthma) in 6% cases. Patients from low-income families were in 82.3% of cases. 72.5% of the cases had a prolonged state of stress by migrant parents for working abroad [38.7% only one parent (30% mother) and both parents in 17.7% of cases], divorce in the family in 11.6% of cases, unmarried mother in 2.8% of cases, and a close relative recently deceased in 1.7% of patients.Subcategories of JIA included: polyarticular JIA negative Rheumatoid Factor (RF) in 39.77% of cases, enthesitis-related arthritis in 27.07% of cases, polyarticular JIA positive RF in 14.36% of cases, oligoarticular JIA in 14.9% of cases, systemic JIA in 3.31% of cases and psoriatic JIA in 0.59% of patients.Conclusion:Both the data from the questionnaires, but especially the family drawing tests, suggest that the prolonged state of stress with anxiety, sadness, pain and depression, in combination with starvation, lack of parental love and the genetic predisposition, have contributed to the emergence of chronic arthritis, pathology that is growing more and more in recent years in Romania.References:[1] Dube SR, Fairweather D, Pearson WS, Felitti VJ, Anda RF, Croft JB. Cumulative childhood stress and autoimmune disease in adults. Psychosom Med. 2009; 71:243–250.[2] Song H, Fang F, Tomasson G, et al. Association of stress-related disorders with subsequent autoimmune disease. JAMA, 2018; 319:2388–2400.[3] Vallerand IA, Patten SB, Barnabe C. Depression and the risk of rheumatoid arthritis. Curr Opin Rheumatol. 2019; 31(3):279-284.Disclosure of Interests:None declared

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OBJECTIVES/GOALS: Characterize formal informatics methods and approaches for enabling reproducible translational research. Education of reproducible methods to translational researchers and informaticians. METHODS/STUDY POPULATION: We performed a scoping review [1] of selected informatics literature (e.g. [2,3]) from PubMed and Scopus. In addition we reviewed literature and documentation of translational research informatics projects [4–21] at the University of Utah. RESULTS/ANTICIPATED RESULTS: The example informatics projects we identified in our literature covered a broad spectrum of translational research. These include research recruitment, research data requisition, study design and statistical analysis, biomedical vocabularies and metadata for data integration, data provenance and quality, and uncertainty. Elements impacting reproducibility of research include (1) Research Data: its semantics, quality, metadata and provenance; and (2) Research Processes: study conduct including activities and interventions undertaken, collections of biospecimens and data, and data integration. The informatics methods and approaches we identified as enablers of reproducibility include the use of templates, management of workflows and processes, scalable methods for managing data, metadata and semantics, appropriate software architectures and containerization, convergence methods and uncertainty quantification. In addition these methods need to be open and shareable and should be quantifiable to measure their ability to achieve reproducibility. DISCUSSION/SIGNIFICANCE OF IMPACT: The ability to collect large volumes of data collection has ballooned in nearly every area of science, while the ability to capturing research processes hasn’t kept with this pace. Potential for problematic research practices and irreproducible results are concerns.Reproducibility is a core essentially of translational research. Translational research informatics provides methods and means for enabling reproducibility and FAIRness [22] in translational research. In addition there is a need for translational informatics itself to be reproducible to make research reproducible so that methods developed for one study or biomedical domain can be applied elsewhere. Such informatics research and development requires a mindset for meta-research [23].The informatics methods we identified covers the spectrum of reproducibility (computational, empirical and statistical) and across different levels of reproducibility (reviewable, replicable, confirmable, auditable, and open or complete) [24–29]. While there are existing and ongoing efforts in developing informatics methods for translational research reproducibility in Utah and elsewhere, there is a need to further develop formal informatics methods and approaches: the Informatics of Research Reproducibility.In this presentation, we summarize the studies and literature we identified and discuss our key findings and gaps in informatics methods for research reproducibility. We conclude by discussing how we are covering these topics in a translational research informatics course.1.Pham MT, Rajić A, Greig JD, Sargeant JM, Papadopoulos A, McEwen SA. A scoping review of scoping reviews: advancing the approach and enhancing the consistency. Res Synth Methods. 2014 Dec;5(4):371–85.2.McIntosh LD, Juehne A, Vitale CRH, Liu X, Alcoser R, Lukas JC, Evanoff B. Repeat: a framework to assess empirical reproducibility in biomedical research. BMC Med Res Methodol [Internet]. 2017 Sep 18 [cited 2018 Nov 30];17. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604503/3.Denaxas S, Direk K, Gonzalez-Izquierdo A, Pikoula M, Cakiroglu A, Moore J, Hemingway H, Smeeth L. Methods for enhancing the reproducibility of biomedical research findings using electronic health records. BioData Min. 2017;10:31.4.Burnett N, Gouripeddi R, Wen J, Mo P, Madsen R, Butcher R, Sward K, Facelli JC. Harmonization of Sensor Metadata and Measurements to Support Exposomic Research. In: 2016 International Society of Exposure Science [Internet]. Research Triangle Park, NC, USA; 2017 [cited 2017 Jun 17]. Available from: http://www.intlexposurescience.org/ISES20175.Butcher R, Gouripeddi RK, Madsen R, Mo P, LaSalle B. CCTS Biomedical Informatics Core Research Data Service. In Salt Lake City; 2016.6.Cummins M, Gouripeddi R, Facelli J. A low-cost, low-barrier clinical trials registry to support effective recruitment. In Salt Lake City, Utah, USA; 2016 [cited 2018 Nov 30]. Available from: //campusguides.lib.utah.edu/UtahRR16/abstracts7.Gouripeddi R, Warner P, Madsen R, Mo P, Burnett N, Wen J, Lund A, Butcher R, Cummins MR, Facelli J, Sward K. An Infrastructure for Reproducibile Exposomic Research. In: Research Reproducibility 2016 [Internet]. Salt Lake City, Utah, USA; 2016 [cited 2018 Nov 30]. Available from: //campusguides.lib.utah.edu/UtahRR16/abstracts8.Eilbeck K, Lewis SE, Mungall CJ, Yandell M, Stein L, Durbin R, Ashburner M. The Sequence Ontology: a tool for the unification of genome annotations. Genome Biol. 2005;6:R44.9.Gouripeddi R, Cummins M, Madsen R, LaSalle B, Redd AM, Presson AP, Ye X, Facelli JC, Green T, Harper S. Streamlining study design and statistical analysis for quality improvement and research reproducibility. J Clin Transl Sci. 2017 Sep;1(S1):18–9.10.Gouripeddi R, Eilbeck K, Cummins M, Sward K, LaSalle B, Peterson K, Madsen R, Warner P, Dere W, Facelli JC. A Conceptual Architecture for Reproducible On-demand Data Integration for Complex Diseases. In: Research Reproducibility 2016 (UtahRR16) [Internet]. Salt Lake City, Utah, USA; 2016 [cited 2017 Apr 25]. Available from: https://zenodo.org/record/16806711.Gouripeddi R, Lane E, Madsen R, Butcher R, LaSalle B, Sward K, Fritz J, Facelli JC, Cummins M, Shao J, Singleton R. Towards a scalable informatics platform for enhancing accrual into clinical research studies. J Clin Transl Sci. 2017 Sep;1(S1):20–20.12.Gouripeddi R, Deka R, Reese T, Butcher R, Martin B, Talbert J, LaSalle B, Facelli J, Brixner D. Reproducibility of Electronic Health Record Research Data Requests. In Washington, DC, USA; 2018 [cited 2018 Apr 21]. Available from: https://zenodo.org/record/1226602#.WtvvyZch27013.Gouripeddi R, Mo P, Madsen R, Warner P, Butcher R, Wen J, Shao J, Burnett N, Rajan NS, LaSalle B, Facelli JC. A Framework for Metadata Management and Automated Discovery for Heterogeneous Data Integration. In: 2016 BD2K All Hands Meeting [Internet]. Bethesda, MD; November 29-30 [cited 2017 Apr 25]. Available from: https://zenodo.org/record/16788514.Groat D, Gouripeddi R, Lin YK, Dere W, Murray M, Madsen R, Gestaland P, Facelli J. Identification of High-Level Formalisms that Support Translational Research Reproducibility. In: Research Reproducibility 2018 [Internet]. Salt Lake City, Utah, USA; 2018 [cited 2018 Oct 30]. Available from: //campusguides.lib.utah.edu/UtahRR18/abstracts15.Huser V, Kahn MG, Brown JS, Gouripeddi R. Methods for examining data quality in healthcare integrated data repositories. Pac Symp Biocomput Pac Symp Biocomput. 2018;23:628–33.16.Lund A, Gouripeddi R, Burnett N, Tran L-T, Mo P, Madsen R, Cummins M, Sward K, Facelli J. Enabling Reproducible Computational Modeling: The Utah PRISMS Ecosystem. In Salt Lake City, Utah, USA; 2018 [cited 2018 Oct 30]. Available from: //campusguides.lib.utah.edu/UtahRR18/abstracts17.Pflieger LT, Mason CC, Facelli JC. Uncertainty quantification in breast cancer risk prediction models using self-reported family health history. J Clin Transl Sci. 2017 Feb;1(1):53–9.18.Shao J, Gouripeddi R, Facelli J. Improving Clinical Trial Research Reproducibility using Reproducible Informatics Methods. In Salt Lake City, Utah, USA; 2018 [cited 2018 Oct 30]. Available from: //campusguides.lib.utah.edu/UtahRR18/abstracts19.Shao J, Gouripeddi R, Facelli JC. Semantic characterization of clinical trial descriptions from ClincalTrials.gov and patient notes from MIMIC-III. J Clin Transl Sci. 2017 Sep;1(S1):12–12.20.Tiase V, Gouripeddi R, Burnett N, Butcher R, Mo P, Cummins M, Sward K. Advancing Study Metadata Models to Support an Exposomic Informatics Infrastructure. In Ottawa, Canada; 2018 [cited 2018 Oct 30]. Available from: = http://www.eiseverywhere.com/ehome/294696/638649/?&t=8c531cecd4bb0a5efc6a0045f5bec0c321.Wen J, Gouripeddi R, Facelli JC. Metadata Discovery of Heterogeneous Biomedical Datasets Using Token-Based Features. In: IT Convergence and Security 2017 [Internet]. Springer, Singapore; 2017 [cited 2017 Sep 6]. p. 60–7. (Lecture Notes in Electrical Engineering). Available from: https://link.springer.com/chapter/10.1007/978-981-10-6451-7_822.Wilkinson MD, Dumontier M, Aalbersberg IjJ, Appleton G, Axton M, Baak A, Blomberg N, Boiten J-W, da Silva Santos LB, Bourne PE, Bouwman J, Brookes AJ, Clark T, Crosas M, Dillo I, Dumon O, Edmunds S, Evelo CT, Finkers R, Gonzalez-Beltran A, Gray AJG, Groth P, Goble C, Grethe JS, Heringa J, ’t Hoen PAC, Hooft R, Kuhn T, Kok R, Kok J, Lusher SJ, Martone ME, Mons A, Packer AL, Persson B, Rocca-Serra P, Roos M, van Schaik R, Sansone S-A, Schultes E, Sengstag T, Slater T, Strawn G, Swertz MA, Thompson M, van der Lei J, van Mulligen E, Velterop J, Waagmeester A, Wittenburg P, Wolstencroft K, Zhao J, Mons B. The FAIR Guiding Principles for scientific data management and stewardship. Sci Data. 2016 Mar 15;3:160018.23.Ioannidis JPA. Meta-research: Why research on research matters. PLOS Biol. 2018 Mar 13;16(3):e2005468.24.Stodden V, Borwein J, Bailey DH. Setting the default to reproducible. Comput Sci Res SIAM News. 2013;46(5):4–6.25.Stodden V, Mcnu*tt M, Bailey DH, Deelman E, Gil Y, Hanson B, Heroux MA, Ioannidis JPA, Taufer M. Enhancing reproducibility for computational methods. Science. 2016 Dec 9;354(6317):1240–1.26.Stodden V, Mcnu*tt M, Bailey DH, Deelman E, Gil Y, Hanson B, Heroux MA, Ioannidis JPA, Taufer M. Enhancing reproducibility for computational methods. Science. 2016 Dec 9;354(6317):1240–1.27.Stodden V. Reproducible Research for Scientific Computing: Tools and Strategies for Changing the Culture. Comput Sci Eng. 2012 Jul 1;14(4):13–7.28.Baker M. Muddled meanings hamper efforts to fix reproducibility crisis. Nat News Available from: http://www.nature.com/news/muddled-meanings-hamper-efforts-to-fix-reproducibility-crisis-1.2007629.Barba LA. Terminologies for Reproducible Research. ArXiv180203311 Cs 2018 Feb 9; Available from: http://arxiv.org/abs/1802.03311

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This article is dedicated to the development and presentation of the results of the first phase of implementation of the project "Knowledge, research and curricular innovations in teacher training for ethnic-racial diversity in higher education: questioning and contributions of ethnic-racial matrices and (NEAB / UFSCar), Brazil, linked to the Abdias Nascimento Academic Development Program, promoted by the Coordination for the Improvement of Higher Education Personnel (CAPES). The project aims to establish a transnational network of joint research between researchers in partnership with three international institutions: Universidad Distrital Francisco José de Caldas (Colombia), Georgia State University (USA) and Université Paris Nanterre (France). The project aims to analyze if and how the curriculum of teacher training courses are changing for the dialogue of ethnic-racial and cultural knowledge, African and Afro-descendant knowledge. In this article we present a review of the literature on this subject in the contexts of Colombia and the United States.ResumoEste artigo apresenta alguns resultados da primeira fase de implementação do projeto “Conhecimento, pesquisa e inovações curriculares na formação de professores para a diversidade étnico-racial no ensino superior: questionamentos e contribuições das matrizes étnico-raciais e culturais, de saberes africanos e afrodescendentes” do Núcleo de Estudos Afro-Brasileiros da Universidade Federal de São Carlos (NEAB/UFSCar), vinculado ao Programa de Desenvolvimento Acadêmico Abdias Nascimento fomentado pela Coordenação de Aperfeiçoamento do Pessoal de Nível Superior (CAPES). O projeto visa estabelecer uma rede transnacional de investigação conjunta entre pesquisadores e pesquisadoras em parceria com três instituições internacionais: Universidad Distrital Francisco José de Caldas (Colômbia), Georgia State University (EUA) e Université Paris Nanterre (França). O projeto objetiva analisar se e de que forma os currículos dos cursos de formação de professores estão se modificando para o diálogo de conhecimentos étnico-raciais e culturais, de saberes africanos e afrodescendentes. Neste artigo apresentamos um recorte do levantamento bibliográfico sobre este tema nos contextos da Colômbia e dos Estados Unidos.Keywords: Curriculum, Higher education, Ethnic-racial diversity, Affirmative action policies.Palavras-chave: Currículo, Ensino superior, Diversidade étnico-racial, Políticas de ação afirmativa.ReferencesALRIDGE, Derrick. Teachers in the movement: Pedagogy, Activism, and Freedom. Disponível em: http://www.aera.net/Publications/Online-Paper-Repository/AERA-Online-Paper-Repository/Owner/912849 Acessado em outubro de 2018.AU, Wayne; BROWN, Anthony L.; CALDERON, Dolores. How does it feel to be a problem? Communities of Color, Self-Determination, and Historical Educational Struggle, 2018.BRAH, Avtar. Cartografías de la diáspora: identidades en cuestión. Madrid: Traficante de sueños, 2011.BURAS, KRISTEN L. George Washington Carver Senior High School: A Legacy That Can't Be Chartered, 2018. Disponível em: http://www.aera.net/Publications/Online-Paper-Repository/AERA-Online-Paper-Repository/Owner/912849 Acessado em outubro de 2018.CASTILLO GUZMAN, Elizabeth; CAICEDO ORTIZ, José Antonio. Las luchas por otras educaciones en el bicentenario: de la iglesia-docente a las educaciones étnicas. Nómadas, Bogotá, n. 33, p. 109-127, Oct. 2010.CASTILLO, S. S.; ABRIL, N. G. P. Colômbia: Invisibilidade e exclusão. In: DIJK, T. A. Van. Racismo e discurso na América Latina. São Paulo: Contexto, 2008.CASTRO SUAREZ, Celmira, En busca de la igualdad y el reconocimiento. La experiencia histórica de la educación intercultural en el Caribe colombiano. Memorias. Revista Digital de Historia y Arqueología desde el Caribe [en linea] 2014. Disponível em: <http://www.redalyc.org/articulo.oa?id=85532558010> acesso em: 05 de novembro de 2017.COLÔMBIA. Lei 70 de 1993. Por la cual se desarrolla el artículo transitório 55 de la Constitucion política. El Congresso de Colômbia. 1993.DÍAZ SÁNCHEZ, Edisson. Reflexiones pedagógicas sobre la formación de docentes en los estudios escolares afrocolombianos. Revista Colombiana de Educación, [S.l.], n. 69, p. 183.202, 2015. ISSN 2323-0134.DU BOIS, William E. Burghardt. As almas da gente negra. Tradução de Heloisa Toller Gomes. Rio de Janeiro: Lacerda, 1999.DUSSEL, Enrique. 1492: El encubrimiento del otro: hacia el origen del mito de la modernidad. UMSA. Facultad de Humanidades y Ciencias de la Educación. Plural Editores: La Paz, 1994.ESTEBAN-GUITART, Moisés et al. Empatia y tolerancia a la diversidad en un contexto educativo intercultural. Univ. Psychol., Bogotá, v. 11, n. 2, p. 415-426, June 2012.GOMES, Nilma Lino. O movimento negro educador: saberes construídos nas lutas por emancipação. Petrópolis, RJ: Vozes, 2017. 154 p.GRANADOS-BELTRAN, Carlo. Interculturalidad crítica. Un camino para profesores de inglés en formación. Íkala, Medellín, v. 21, n. 2, p. 171-187, Aug. 2016. GRANT, CARL A.; BROWN, KEFFRELYN D.; BROWN, ANTHONY L. Black intellectual thought in education: The missing traditions of Anna Julia Copper, Carter G. Woodson, and Alain Le Roy Locke. Routledge: New York, 2016. HOOKS, Bell. Ensinando a transgredir: a educação como prática da liberdade. Trad. Marcelo Brandão Cipolla. São Paulo: WMF Martins Fontes, 2013.JIMENEZ, Nidia N.; GULLO, Maria, A. C.; MONTES, Jorge, E. O. Perception to the literacy process of adults and young natives from Guainía Department Colombia: Look of the protagonists. Investigación & desarrollo, vol. 24, n.° 1, 2016.KING, Joyce Elaine. Minds Stayed on Freedom. 2018. Disponível em http://www.aera.net/Publications/Online-Paper-Repository/AERA-Online-Paper-Repository/Owner/23358.KING, Joyce Elaine. Black education post-Katrina. And all us we are not saved. Epilogue: In: TILLMAN, L. C., (Ed.). The SAGE Handbook of African American Education (pp. 499-510). Thousand Oaks, CA: Sage, 2009.LAGO DE ZOTA, Alejandrina; LAGO DE FERNANDEZ, Carmen; LAGO DE VERGARA, Diana. Educación para ciudadanos del mundo con identidad afrodescendiente: caso institución educativa Antonia Santos, Cartagena de Índias, Colombia. Rev. hist.edu.latinoam - Vol. 14 No. 18, - pp. 53 – 74 enero – junio 2012.MBEMBE, Achille. Afropolitanismo. Áskesis. Revista dxs Discentes do Programa de Pós-Graduação em Sociologia da UFSCar. Trad. Cleber Daniel Lambert da Silva. v. 4, n. 2, 2015, Julho/Dezembro, pp. 68-71.MBEMBE, Achille. Afriques indociles: christianisme, pouvoir et etat en société postcoloniale. Paris: Editions Karthala, 1988.MEN - Ministerio de Educación Nacional. Serie lineamientos curriculares: Cátedra Estudios Afrocolombianos. 1997.MENESES-COPETE, Yeison. A. Representaciones sociales sobre afrodescendencia: curriculum, practica y discurso pedagógico del profesorado. Entramado. Vol. 10 No.2, 2014.MORA MONROY, Gloria E. Dos experiencias educativas y editoriales con estudiantes indígenas, afrodescendientes y de municipios pobres en la universidad, desde una perspectiva intercultural. Forma funcion, Santaf, de Bogot, D.C., Bogotá, v. 29, n. 1, p. 61-80, Jan. 2016.RODRIGUES, Cristiano. Movimentos negros, políticas públicas e desigualdades raciais no Brasil e Colômbia. CLEA. Debates Latinoamericanos. Año 12, volumen 1/2014.ROJAS, Alex. Cátedra de Estudios Afrocolombianos: Aportes para maestros. Universidad del Cauca. 2008.SANTOS, Doris. Mimesis y bilingüismo ideológico: un análisis crítico del discurso sobre la diversidad en un documento de política educativa universitaria en América Latina. Forma funcion, Santaf, de Bogot, D.C. [online]. vol.26, n.1. pp.183-216, 2013.SCHOMBURG, Arturo. The negro digs up his past. In: The Survey, The Negro Expresses Himself. March (1), 1925. pp. 670-672.

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The hospitality industry is under intense pressure. COVID-19 restrictions and limited trading opportunities have forced restaurateurs to consider their pricing structures. Reflecting those concerns, Richard Corney, MD of the Inigo Coffee Group, proposed that the retail price of a cup of coffee needed to rise to between $6.50 and $7.00 to “take into account all the other cost increases hospitality establishments have experienced in the last decade, not to mention the challenges of the pandemic in the last two years” [1]. Alongside these revenue issues, the industry also needs to move away from a tradition of low pay and low value [2], and perhaps towards the concept of a ‘hospitable wage’ [3]. However, laudable as these goals might be, upward price movement may be resisted by many customers. So how can restaurateurs and hoteliers ‘sell’ revised-price-products to their customers? Clearly, increased revenue can be achieved through both marginal price increases and up-selling to increase average customer spend. We propose that both of these goals can be achieved if employers embrace the concept of hospitality as an experience [4, 5], where the performance of staff is central [6], and where the experience is delivered with ‘hospitality personality’. Much has been written about the personality of hospitality staff. Most of that work can be traced back to the early work of Erving Goffman [7] who proposed that hospitality employees were playing roles, and acting out, by using their emotional intelligence. Goffman likened such workers to actors who literally ‘take on’ a character. The characteristics of the hospitality personality have been explored by many authors [8–10] and include, agreeableness, extroversion, openness to experience, conscientiousness, and emotional stability; although some research also reveals that neuroticism is also a hospitality characteristic in hotel receptionists. Alongside this research, other studies have identified the role of mood and personality in positive guest experiences, specifically service quality perception and customer satisfaction [11]. This supports our suggestion that the performance of staff can have a direct impact on customer experience and potentially revenue, and that Corney’s price recommendation could be a realistic option for many businesses struggling economically. But there’s a ‘fly in the ointment’: the Tall Poppy Syndrome. Tall poppy syndrome originated around 500BC in ancient Rome, when King Tarquinius Superbus demonstrated how the nation should deal with its enemies. In an active display he lopped off the heads of the tallest poppies in his garden with a stick [12]. Today, tall poppies are conspicuously successful people, who may attract envy, resentment or hostility, and the Tall Poppy Syndrome (TPS) is the habit of others to diminish those who have attained excellence in a field – to cut them down to size [13]. While TPS is commonly associated with Australia and New Zealand, it is also part of other cultures. Within Scandinavian cultures, janteloven1 promotes humility and conformity paralleling TPS [15]; in Japanese culture, ‘the nail that sticks up gets pounded down’ [16]; and within Filipino culture a crab mentality exists whereby crabs in a bucket tend to pull back any adventurous crabs trying to escape [17]. TPS is often described as being ingrained in New Zealand culture [18] and has been identified as a phenomenon in New Zealand entrepreneurship and business [19]. While TPS encourages conformist cultures, our research provides a valuable insight into how employers can spot potential employees who actively resist notions of TPS’s conformity and are more likely to perform to the highest levels. Using Instagram, we interviewed 1000 young self-identifying New Zealanders to explore their qualitative experiences of TPS. They identified as 68% female and 32% male. Their age ranges were: 58% aged 18–24; 27% aged 25–34; 7% aged 35–44; 3% aged 45–54; and 2% aged 55 or above. Three percent of the respondents were excluded from our final sample because they were aged 17 or younger. The respondents’ feelings, victimhood, self-esteem, and knowledge about TPS provided our research with the largest amount of data. Of our 1000 participants, 50% knew what TPS was, while 50% did not. Similarly, 45% of our respondents claimed to be victims of TPS. Contrastingly, 55% had no experiences of TPS. Within those considerations, the data revealed clearly that TPS was perceived by participants as ‘something done to them’ and not as ‘something they do to other people’. Yet, and despite that difference, the pervasive nature of TPS within Kiwi socio-culture was noted by participants. Several participants recounted the cost of TPS; for example, “Definitely held me back. It can knock your confidence so much” and “Made me want to hide/play down my talents/my life.” Other participants perceived TPS “put-downs” (belittling or humiliating remarks) as a challenge or motivating force. They commented, “Uncomfortable but it pushed me harder to be even more successful” and “It motivated me. I realized people saw something in me and strived to continue improving.” For the 45% of our participants directly experiencing TPS, those experiences were grounded within two base reactions. Reflecting that, more than half of our participants adopted conformist behaviours, succumbing to the bullying pressures of others. However, 45% recognised TPS and its bullying as a motivator to create further behaviours and actions of excellence. The role of social media in TPS was significant. Participants directly linked TPS to social media with 89% of respondents recognising the role of social media in TPS. Key to their views was the realisation that social media not only provided distance between people but also that people used social media to manipulate the image they projected to others. In those ways, social media was a mediating factor. As participants observed, “Easier to be mean and cut someone down through a comment than to their face” and “Social media has made it easier to abuse and put down those that stand out.” Given the attributes of the hospitality personality, and Richard Corney’s proposed pricing restructures in hospitality, the key is for employers to consider the resilience of their staff to TPS and conformity. They should consider whether they can recruit and retain the 45% of staff that use TPS as inspiration to succeed – the staff who will rise the challenge of delivering exceptional customer experiences through their own performance of the ‘hospitality personality’. It is within the unique characteristics of these staff that hospitality businesses can generate that extra point of difference and experience that customers will be happy to pay a little more to enjoy; and perhaps hospitality businesses might go a step further by also considering the concept of the ‘hospitable wage’. Corresponding author Lindsay Neill can be contacted at: lindsay.neill@aut.ac.nz Note “Janteloven (the law of Jante) at its simplest describes the way that all Norwegians (and in fact, other Scandinavians too) behave: putting society ahead of the individual, not boasting about individual accomplishments, and not being jealous of others” [14]. References (1) Wilkes, M. We Need to Pay $7 for a Flat White if Cafes are Going to Survive, Says Coffee Boss, 2021. https://www.stuff.co.nz/life-style/food-drink/drinks/127196374/we-need-to-pay-7-for-a-flat-white-if-cafes-are-going-to-survive-says-coffee-boss (accessed Dec 12, 2021). (2) Te Ora, N. Does Hospitality Have a Low Wages Problem? Workers Say Yes. Some Restaurant Owners Say No, 2021. https://www.stuff.co.nz/business/industries/125301113/does-hospitality-have-a-low-wages-problem-workers-say-yes-some-restaurant-owners-say-no (accessed Dec 10, 2021). (3) Douglas, J.; Williamson, D.; Harris, C. Dirty Deeds Done Dirt Cheap: Creating “Hospitable Wages” through the Living Wage Movement. Hospitality & Society 2020, 10 (1), 3–22. (4) Hemmington, N. From Service to Experience: Understanding and Defining the Hospitality Business. The Service Industries Journal 2007, 27 (6), 747–755. (5) Lugosi, P. Hospitality Spaces, Hospitable Moments: Consumer Encounters and Affective Experiences in Commercial Settings. Journal of Foodservice 2008, 19 (2), 139–149. (6) Morgan, M.; Watson, P.; Hemmington, N. Drama in the Dining Room: Theatrical Perspectives on the Foodservice Encounter. Journal of Foodservice 2008, 19 (2), 111–118. (7) Goffman, E. The Presentation of Self in Everyday Life; Doubleday: Garden City, New York, 1959. (8) Köşker, H.; Unur, K.; Gursoy, D. The Effect of Basic Personality Traits on Service Orientation and Tendency to Work in the Hospitality and Tourism Industry. Journal of Teaching in Travel & Tourism 2019, 19 (2), 140–162. (9) Grobelna, A. Extraversion and its Importance in the Hospitality Workplace. Scientific Journal, No. 876, Economic Problems of Tourism 2015, 3 (31), 89–96. (10) Gonzalez-Gonzalez, T.; García-Almeida, D. J. Frontline Employee-Driven Change in Hospitality Firms: An Analysis of Receptionists’ Personality on Implemented Suggestions. International Journal of Contemporary Hospitality Management 2021, 33 (12), 4439–4459. (11) Kocabulut, Ö.; Albayrak, T. The Effects of Mood and Personality Type on Service Quality Perception and Customer Satisfaction. International Journal of Culture, Tourism, and Hospitality Research 2019, 13 (1), 98–112. (12) Felton, D. Advice to Tyrants: The Motif of “Enigmatic Counsel” in Greek and Roman Texts. Phoenix 1998, 52 (1–2), 42–54. (13) Feather, N. T. Attitudes towards the High Achiever: The Fall of the Tall Poppy. Australian Journal of Psychology 1989, 41 (3), 239–267. (14) Nikel, D. What Exactly Is Janteloven? Life in Norway, 2015. https://www.lifeinnorway.net/what-exactly-is-janteloven/ (accessed Dec 10, 2021). (15) Ahlness A. Janteloven and Social Conformity in Thorbørn Egner’s Literature, 2014. http://ncurproceedings.org/ojs/index.php/NCUR2014/article/view/738 (accessed Oct 8, 2019). (16) Matsumoto, D. Culture and Self: An Empirical Assessment of Markus and Kitayama’s Theory of Independent and Interdependent Self-Construals. Asian Journal of Social Psychology 1999, 2, 289–310. (17) Licuanan, P. A Moral Recovery Program: Building a People – Building a Nation. In: Dy, M. B. (ed) Values in Philippine Culture and Education: Philippine Philosophical Studies, 1; The Council for Research in Values and Philosophy: Washington, DC, 1994, pp. 35–54. (18) Ockhuysen, S. It's Time to Do Better and Cut Tall Poppy Syndrome out of Our Culture. Stuff, Feb 20, 2020. https://www.stuff.co.nz/taranaki-daily-news/news/119627156/its-time-to-do-better-and-cut-tall-poppy-syndrome-out-of-our-culture (accessed Dec 11, 2021) (19) Kirkwood, J. Tall Poppy Syndrome: Implications for Entrepreneurship in New Zealand. Journal of Management & Organization 2007, 13 (4), 366–382.

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To date, discrete event stochastic simulations of large scale biological reaction systems are extremely compute-intensive and time-consuming. Besides, it has been widely accepted that spatial factor plays a critical role in the dynamics of most biological reaction systems. The NSM (the Next Sub-Volume Method), a spatial variation of the Gillespie’s stochastic simulation algorithm (SSA), has been proposed for spatially stochastic simulation of those systems. While being able to explore high degree of parallelism in systems, NSM is inherently sequential, which still suffers from the problem of low simulation speed. Fine-grained parallel execution is an elegant way to speed up sequential simulations. Thus, based on the discrete event simulation framework JAMES II, we design and implement a PDES (Parallel Discrete Event Simulation) TW (time warp) simulator to enable the fine-grained parallel execution of spatial stochastic simulations of biological reaction systems using the ANSM (the Abstract NSM), a parallel variation of the NSM. The simulation results of classical Lotka-Volterra biological reaction system show that our time warp simulator obtains remarkable parallel speed-up against sequential execution of the NSM.I.IntroductionThe goal of Systems biology is to obtain system-level investigations of the structure and behavior of biological reaction systems by integrating biology with system theory, mathematics and computer science [1][3], since the isolated knowledge of parts can not explain the dynamics of a whole system. As the complement of “wet-lab” experiments, stochastic simulation, being called the “dry-computational” experiment, plays a more and more important role in computing systems biology [2]. Among many methods explored in systems biology, discrete event stochastic simulation is of greatly importance [4][5][6], since a great number of researches have present that stochasticity or “noise” have a crucial effect on the dynamics of small population biological reaction systems [4][7]. Furthermore, recent research shows that the stochasticity is not only important in biological reaction systems with small population but also in some moderate/large population systems [7].To date, Gillespie’s SSA [8] is widely considered to be the most accurate way to capture the dynamics of biological reaction systems instead of traditional mathematical method [5][9]. However, SSA-based stochastic simulation is confronted with two main challenges: Firstly, this type of simulation is extremely time-consuming, since when the types of species and the number of reactions in the biological system are large, SSA requires a huge amount of steps to sample these reactions; Secondly, the assumption that the systems are spatially hom*ogeneous or well-stirred is hardly met in most real biological systems and spatial factors play a key role in the behaviors of most real biological systems [19][20][21][22][23][24]. The next sub-volume method (NSM) [18], presents us an elegant way to access the special problem via domain partition. To our disappointment, sequential stochastic simulation with the NSM is still very time-consuming, and additionally introduced diffusion among neighbor sub-volumes makes things worse. Whereas, the NSM explores a very high degree of parallelism among sub-volumes, and parallelization has been widely accepted as the most meaningful way to tackle the performance bottleneck of sequential simulations [26][27]. Thus, adapting parallel discrete event simulation (PDES) techniques to discrete event stochastic simulation would be particularly promising. Although there are a few attempts have been conducted [29][30][31], research in this filed is still in its infancy and many issues are in need of further discussion. The next section of the paper presents the background and related work in this domain. In section III, we give the details of design and implementation of model interfaces of LP paradigm and the time warp simulator based on the discrete event simulation framework JAMES II; the benchmark model and experiment results are shown in Section IV; in the last section, we conclude the paper with some future work.II. Background and Related WorkA. Parallel Discrete Event Simulation (PDES)The notion Logical Process (LP) is introduced to PDES as the abstract of the physical process [26], where a system consisting of many physical processes is usually modeled by a set of LP. LP is regarded as the smallest unit that can be executed in PDES and each LP holds a sub-partition of the whole system’s state variables as its private ones. When a LP processes an event, it can only modify the state variables of its own. If one LP needs to modify one of its neighbors’ state variables, it has to schedule an event to the target neighbor. That is to say event message exchanging is the only way that LPs interact with each other. Because of the data dependences or interactions among LPs, synchronization protocols have to be introduced to PDES to guarantee the so-called local causality constraint (LCC) [26]. By now, there are a larger number of synchronization algorithms have been proposed, e.g. the null-message [26], the time warp (TW) [32], breath time warp (BTW) [33] and etc. According to whether can events of LPs be processed optimistically, they are generally divided into two types: conservative algorithms and optimistic algorithms. However, Dematté and Mazza have theoretically pointed out the disadvantages of pure conservative parallel simulation for biochemical reaction systems [31]. B. NSM and ANSM The NSM is a spatial variation of Gillespie’ SSA, which integrates the direct method (DM) [8] with the next reaction method (NRM) [25]. The NSM presents us a pretty good way to tackle the aspect of space in biological systems by partitioning a spatially inhom*ogeneous system into many much more smaller “hom*ogeneous” ones, which can be simulated by SSA separately. However, the NSM is inherently combined with the sequential semantics, and all sub-volumes share one common data structure for events or messages. Thus, directly parallelization of the NSM may be confronted with the so-called boundary problem and high costs of synchronously accessing the common data structure [29]. In order to obtain higher efficiency of parallel simulation, parallelization of NSM has to firstly free the NSM from the sequential semantics and secondly partition the shared data structure into many “parallel” ones. One of these is the abstract next sub-volume method (ANSM) [30]. In the ANSM, each sub-volume is modeled by a logical process (LP) based on the LP paradigm of PDES, where each LP held its own event queue and state variables (see Fig. 1). In addition, the so-called retraction mechanism was introduced in the ANSM too (see algorithm 1). Besides, based on the ANSM, Wang etc. [30] have experimentally tested the performance of several PDES algorithms in the platform called YH-SUPE [27]. However, their platform is designed for general simulation applications, thus it would sacrifice some performance for being not able to take into account the characteristics of biological reaction systems. Using the similar ideas of the ANSM, Dematté and Mazza have designed and realized an optimistic simulator. However, they processed events in time-stepped manner, which would lose a specific degree of precisions compared with the discrete event manner, and it is very hard to transfer a time-stepped simulation to a discrete event one. In addition, Jeschke etc.[29] have designed and implemented a dynamic time-window simulator to execution the NSM in parallel on the grid computing environment, however, they paid main attention on the analysis of communication costs and determining a better size of the time-window.Fig. 1: the variations from SSA to NSM and from NSM to ANSMC. JAMES II JAMES II is an open source discrete event simulation experiment framework developed by the University of Rostock in Germany. It focuses on high flexibility and scalability [11][13]. Based on the plug-in scheme [12], each function of JAMES II is defined as a specific plug-in type, and all plug-in types and plug-ins are declared in XML-files [13]. Combined with the factory method pattern JAMES II innovatively split up the model and simulator, which makes JAMES II is very flexible to add and reuse both of models and simulators. In addition, JAMES II supports various types of modelling formalisms, e.g. cellular automata, discrete event system specification (DEVS), SpacePi, StochasticPi and etc.[14]. Besides, a well-defined simulator selection mechanism is designed and developed in JAMES II, which can not only automatically choose the proper simulators according to the modeling formalism but also pick out a specific simulator from a serious of simulators supporting the same modeling formalism according to the user settings [15].III. The Model Interface and SimulatorAs we have mentioned in section II (part C), model and simulator are split up into two separate parts. Thus, in this section, we introduce the designation and implementation of model interface of LP paradigm and more importantly the time warp simulator.A. The Mod Interface of LP ParadigmJAMES II provides abstract model interfaces for different modeling formalism, based on which Wang etc. have designed and implemented model interface of LP paradigm[16]. However, this interface is not scalable well for parallel and distributed simulation of larger scale systems. In our implementation, we accommodate the interface to the situation of parallel and distributed situations. Firstly, the neighbor LP’s reference is replaced by its name in LP’s neighbor queue, because it is improper even dangerous that a local LP hold the references of other LPs in remote memory space. In addition, (pseudo-)random number plays a crucial role to obtain valid and meaningful results in stochastic simulations. However, it is still a very challenge work to find a good random number generator (RNG) [34]. Thus, in order to focus on our problems, we introduce one of the uniform RNGs of JAMES II to this model interface, where each LP holds a private RNG so that random number streams of different LPs can be independent stochastically. B. The Time Warp SimulatorBased on the simulator interface provided by JAMES II, we design and implement the time warp simulator, which contains the (master-)simulator, (LP-)simulator. The simulator works strictly as master/worker(s) paradigm for fine-grained parallel and distributed stochastic simulations. Communication costs are crucial to the performance of a fine-grained parallel and distributed simulation. Based on the Java remote method invocation (RMI) mechanism, P2P (peer-to-peer) communication is implemented among all (master-and LP-)simulators, where a simulator holds all the proxies of targeted ones that work on remote workers. One of the advantages of this communication approach is that PDES codes can be transferred to various hardwire environment, such as Clusters, Grids and distributed computing environment, with only a little modification; The other is that RMI mechanism is easy to realized and independent to any other non-Java libraries. Since the straggler event problem, states have to be saved to rollback events that are pre-processed optimistically. Each time being modified, the state is cloned to a queue by Java clone mechanism. Problem of this copy state saving approach is that it would cause loads of memory space. However, the problem can be made up by a condign GVT calculating mechanism. GVT reduction scheme also has a significant impact on the performance of parallel simulators, since it marks the highest time boundary of events that can be committed so that memories of fossils (processed events and states) less than GVT can be reallocated. GVT calculating is a very knotty for the notorious simultaneous reporting problem and transient messages problem. According to our problem, another GVT algorithm, called Twice Notification (TN-GVT) (see algorithm 2), is contributed to this already rich repository instead of implementing one of GVT algorithms in reference [26] and [28].This algorithm looks like the synchronous algorithm described in reference [26] (pp. 114), however, they are essentially different from each other. This algorithm has never stopped the simulators from processing events when GVT reduction, while algorithm in reference [26] blocks all simulators for GVT calculating. As for the transient message problem, it can be neglect in our implementation, because RMI based remote communication approach is synchronized, that means a simulator will not go on its processing until the remote the massage get to its destination. And because of this, the high-costs message acknowledgement, prevalent over many classical asynchronous GVT algorithms, is not needed anymore too, which should be constructive to the whole performance of the time warp simulator.IV. Benchmark Model and Experiment ResultsA. The Lotka-Volterra Predator-prey SystemIn our experiment, the spatial version of Lotka-Volterra predator-prey system is introduced as the benchmark model (see Fig. 2). We choose the system for two considerations: 1) this system is a classical experimental model that has been used in many related researches [8][30][31], so it is credible and the simulation results are comparable; 2) it is simple but helpful enough to test the issues we are interested in. The space of predator-prey System is partitioned into a2D NXNgrid, whereNdenotes the edge size of the grid. Initially the population of the Grass, Preys and Predators are set to 1000 in each single sub-volume (LP). In Fig. 2,r1,r2,r3stand for the reaction constants of the reaction 1, 2 and 3 respectively. We usedGrass,dPreyanddPredatorto stand for the diffusion rate of Grass, Prey and Predator separately. Being similar to reference [8], we also take the assumption that the population of the grass remains stable, and thusdGrassis set to zero.R1:Grass + Prey ->2Prey(1)R2:Predator +Prey -> 2Predator(2)R3:Predator -> NULL(3)r1=0.01; r2=0.01; r3=10(4)dGrass=0.0;dPrey=2.5;dPredato=5.0(5)Fig. 2: predator-prey systemB. Experiment ResultsThe simulation runs have been executed on a Linux Cluster with 40 computing nodes. Each computing node is equipped with two 64bit 2.53 GHz Intel Xeon QuadCore Processors with 24GB RAM, and nodes are interconnected with Gigabit Ethernet connection. The operating system is Kylin Server 3.5, with kernel 2.6.18. Experiments have been conducted on the benchmark model of different size of mode to investigate the execution time and speedup of the time warp simulator. As shown in Fig. 3, the execution time of simulation on single processor with 8 cores is compared. The result shows that it will take more wall clock time to simulate much larger scale systems for the same simulation time. This testifies the fact that larger scale systems will leads to more events in the same time interval. More importantly, the blue line shows that the sequential simulation performance declines very fast when the mode scale becomes large. The bottleneck of sequential simulator is due to the costs of accessing a long event queue to choose the next events. Besides, from the comparison between group 1 and group 2 in this experiment, we could also conclude that high diffusion rate increased the simulation time greatly both in sequential and parallel simulations. This is because LP paradigm has to split diffusion into two processes (diffusion (in) and diffusion (out) event) for two interactive LPs involved in diffusion and high diffusion rate will lead to high proportional of diffusion to reaction. In the second step shown in Fig. 4, the relationship between the speedups from time warp of two different model sizes and the number of work cores involved are demonstrated. The speedup is calculated against the sequential execution of the spatial reaction-diffusion systems model with the same model size and parameters using NSM.Fig. 4 shows the comparison of speedup of time warp on a64X64grid and a100X100grid. In the case of a64X64grid, under the condition that only one node is used, the lowest speedup (a little bigger than 1) is achieved when two cores involved, and the highest speedup (about 6) is achieved when 8 cores involved. The influence of the number of cores used in parallel simulation is investigated. In most cases, large number of cores could bring in considerable improvements in the performance of parallel simulation. Also, compared with the two results in Fig. 4, the simulation of larger model achieves better speedup. Combined with time tests (Fig. 3), we find that sequential simulator’s performance declines sharply when the model scale becomes very large, which makes the time warp simulator get better speed-up correspondingly.Fig. 3: Execution time (wall clock time) of Seq. and time warp with respect to different model sizes (N=32, 64, 100, and 128) and model parameters based on single computing node with 8 cores. Results of the test are grouped by the diffusion rates (Group 1: Sequential 1 and Time Warp 1. dPrey=2.5, dPredator=5.0; Group 2: dPrey=0.25, dPredator=0.5, Sequential 2 and Time Warp 2).Fig. 4: Speedup of time warp with respect to the number of work cores and the model size (N=64 and 100). Work cores are chose from one computing node. Diffusion rates are dPrey=2.5, dPredator=5.0 and dGrass=0.0.V. Conclusion and Future WorkIn this paper, a time warp simulator based on the discrete event simulation framework JAMES II is designed and implemented for fine-grained parallel and distributed discrete event spatial stochastic simulation of biological reaction systems. Several challenges have been overcome, such as state saving, roll back and especially GVT reduction in parallel execution of simulations. The Lotka-Volterra Predator-Prey system is chosen as the benchmark model to test the performance of our time warp simulator and the best experiment results show that it can obtain about 6 times of speed-up against the sequential simulation. The domain this paper concerns with is in the infancy, many interesting issues are worthy of further investigated, e.g. there are many excellent PDES optimistic synchronization algorithms (e.g. the BTW) as well. Next step, we would like to fill some of them into JAMES II. In addition, Gillespie approximation methods (tau-leap[10] etc.) sacrifice some degree of precision for higher simulation speed, but still could not address the aspect of space of biological reaction systems. The combination of spatial element and approximation methods would be very interesting and promising; however, the parallel execution of tau-leap methods should have to overcome many obstacles on the road ahead.AcknowledgmentThis work is supported by the National Natural Science Foundation of China (NSF) Grant (No.60773019) and the Ph.D. Programs Foundation of Ministry of Education of China (No. 200899980004). The authors would like to show their great gratitude to Dr. Jan Himmelspach and Dr. Roland Ewald at the University of Rostock, Germany for their invaluable advice and kindly help with JAMES II.ReferencesH. Kitano, "Computational systems biology." Nature, vol. 420, no. 6912, pp. 206-210, November 2002.H. Kitano, "Systems biology: a brief overview." 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Resenha do NATIONAL READING PANEL (NRP). Teaching children to read: an evidence-based assessment of the scientific research literature on reading and its implications for reading instruction – reports of the subgroups. Washington, D. C.: U. S. Department of Health and Human Services, National Institute of ChildHealth and Human Development, 2000. Available in: <https:// www.nichd.nih.gov/publications/pubs/nrp/smallbook>. Access in: 26 abr. 2020.

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ObjectiveTo assess evidence for public health impact of syndromic surveillance.IntroductionSystematic syndromic surveillance is undergoing a transition. Building on traditional roots in bioterrorism and situational awareness, proponents are demonstrating the timeliness and informative power of syndromic surveillance data to supplement other surveillance data.MethodsWe used PubMed and Google Scholar to identify articles published since 2007 using key words of interest (e.g., syndromic surveillance in combinations with emergency, evaluation, quality assurance, alerting). The following guiding questions were used to abstract impact measures of syndromic surveillance: 1) what was the public health impact; what decisions or actions occurred because of use of syndromic surveillance data?, 2) were there specific interventions or performance measures for this impact?, and 3) how, and by whom, was this information used?ResultsThirty-five papers were included. Almost all articles (n=33) remarked on the ability of syndromic surveillance to improve public health because of timeliness and/or accuracy of data. Thirty-four articles mentioned that syndromic surveillance data was used or could be useful. However, evidence of health impact directly attributable to syndromic surveillance efforts were lacking. Two articles described how syndromic data were used for decision-making. One article measured the effect of data utilization.ConclusionsWithin the syndromic surveillance literature instances of a conceptual shift from detection to practical response are plentiful. As the field of syndromic surveillance continues to evolve and is used by public health institutions, further evaluation of data utility and impact is needed.ReferencesAyala, A., Berisha, V., Goodin, K., Pogreba-Brown, K., Levy, C., McKinney, B., Koski, L., & Imholte, S. (2016). Public health surveillance strategies for mass gatherings: Super Bowl XLIX and related events, Maricopa County, Arizona, 2015. Health Security, 14(3), 173-84. doi: 10.1089/hs.2016.0029.Bermis, K., Frias, M., Patel, M.T., & Christiansen, D. (2017). Using an Emergency Department Syndromic Surveillance System to Evaluate Reporting of Potential Rabies Exposures, Illinois, 2013-2015. Public Health Reports 132(Supplement 1) 59S-64S."Borroto, R., Williamson, B., Pitcher, P., Ballester, L., Smith, W., Soetebier, K., & Drenzek, C. (2016). Using Syndromic Surveillance Alert Protocols for Epidemiologic Response in Georgia. Online Journal of Public Health Informatics 9(1):e123. doi:10.5210/ojphi.v9i1.7707."Daly, E.R., Dufault, K., Swenson, D.J., Lakevicius, P., Metcalf, E., & Chan, B.P. (2017). Use of emergency department data to monitor and respond to an increase in opioid overdoses in New Hampshire 2011-2015. 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Risk of Fall-Related Injury due to Adverse Weather Events, Philadelphia, Pennsylvania, 2006-2011. Public Health Reports (132) 53S-58S. doi: 10.1177/0033354917706968"Gonzales-Colon, F.J., Lake, I., Barker, G., Smith, G.E., Elliot, A.J., & Morbey, R. (2016). Using Bayesian Networks to assist decision-making in syndromic surveillance. Online Journal of Public Health Informatics, 8(1), e15. doi:10.5210/ojphi.v8i1.6415"Harmon, KJ., Proescholdbell, S., Marshall, S., & Waller, A. (2014). Utilization of emergency department data for drug overdose surveillance in North Carolina. Online Journal of Public Health Informatics 6(1), e174. doi: 10.5210/ojphi.v6i1.5200Harris, J.K., Mansour, R., Choucair, B., Olson, J., Nissen, C., & Bhatt, J. (2014). Health department use of social media to identify foodborne illness—Chicago, Illinois, 2013-2014. MMWR Morbidity and Mortality Weekly Report 63(32), 681-685. Retrieved from: https://www.cdc.gov/mmwr/preview/mmwrhtml/mm6332a1.htm"Harrison, C., Jorder, M., Stern, H., Stavinksy, F., Reddy, V., Hanson, H., Waechter, H., Lowe, L., Gravano, L., & Balter, S. (2014). Using online reviews by restaurant patrons to identify unreported cases of foodborne illness — New York City, 2012–2013. MMWR Morbidity and Mortality Weekly Report 63(20), 441-445. Retrieved from:https://www.cdc.gov/MMWr/preview/mmwrhtml/mm6320a1.htm"Hawkins, J.B., Tuli, G., Kluberg, S., Harris, J., Brownstein, J.S., & Nsoesie, E. (2016). A digital platform for local foodborne illness and outbreak surveillance. Online Journal of Public Health Informatics 8(1), e60. http://dx.doi.org/10.5210/ojphi.v8i1.6474Hines, J.Z., Bancroft, J., Powell, M., & Hedberg, K. (2017). Case finding using syndromic surveillance data during an outbreak of Shiga Toxin–Producing Escherichia coli O26 infections, Oregon, 2015. Public Health Reports, epublication. https://doi.org/10.1177/0033354917708994Hudson, L. T., Klekamp, B.G., & Matthews, S.D. (2017). Local Public Health Surveillance of Heroin-Related Morbidity and Mortality, Orange County, Florida, 2010-2014. Public Health Reports (132), 80S-87SHughes, H.E., Morbey, R., Hughes, T.C., Locker, T.E., Pebody, R., Green, H.K., Ellis, J., Smith, G.E., & Elliot, A.J. (2016). Emergency department syndromic surveillance providing early warning of seasonal respiratory activity in England. Epidemiology and Infection, 144(5), 1052-64. doi: 10.1017/S0950268815002125Hughes, H.E., Morbey, R., Hughes, T.C., Locker, T.E., Shannon, T., Carmichael, C., Murray, V., Ibbotson, S., Catchpole, M., McCloskey, B., Smith, G., & Elliot, A.J. (2014). Using an emergency department syndromic surveillance system to investigate the impact of extreme cold weather events. Public Health, 128(7), 628-635. doi: 10.1016/j.puhe.2014.05.007Ising, A., Proescholdbell, S., Harmon, K.J., Sachdeva, N., Marshall, S.W., & Waller, A.E. (2016). Use of syndromic surveillance data to monitor poisonings and drug overdoses in state and local public health agencies. Injury Prevention 22:i43-i49.http://dx.doi.org/10.1136/injuryprev-2015-041821"Johnson, J. I., & Brown, K. (2015). Validation of emergency department and outpatient data using ILI syndrome classifiers. Online Journal of Public Health Informatics, 7(1), e83. http://doi.org/10.5210/ojphi.v7i1.5749Lall, R., Abdelnabi , J., Ngai, S., Parton, H.B., Saunders, K., Sell, J., Wahnich, A., Weiss, D., Marthes, R.W. (2017). Advancing the Use of Emergency Department Syndromic Surveillance Data, New York City, 2012-2016. Public Health Reports (132), 23S-30SLiljeqvist, H. T., Muscatello, D., Sara, G., Dinh, M., & Lawrence, G. L. (2014). Accuracy of automatic syndromic classification of coded emergency department diagnoses in identifying mental health-related presentations for public health surveillance. BMC Medical Informatics and Decision Making, 14(84). http://doi.org/10.1186/1472-6947-14-84Lober, W. B., Reeder, B., Painter, I., Revere, D., Goldov, K., Bugni, P. F., & Olson, D. R. (2014). Technical description of the Distribute Project: a community-basedsyndromic surveillance system implementation. Online Journal of Public Health Informatics, 5(3), 224. http://doi.org/10.5210/ojphi.v5i3.4938Mathes, R. W., Ito, K., & Matte, T. (2011). Assessing syndromic surveillance of cardiovascular outcomes from emergency department chief complaint data in New York City. Public Library of Science ONE, 6(2), e14677. http://doi.org/10.1371/journal.pone.0014677O’Connell, E. K., Zhang, G., Leguen, F., Llau, A., & Rico, E. (2010). Innovative uses for syndromic surveillance. Emerging Infectious Diseases, 16(4), 669–671. http://doi.org/10.3201/eid1604.090688Rumoro, D.P., Hallock, M.M., Silva, J., Shah, S.C., Gibbs, G., Trenholme G.M., & Waddell, M.J. (2013). Why does Influenza-Like Illness surveillance miss true influenza cases in the emergency department?: Implications for health care providers. Annals of Emergency Medicine, 62(4), S75. https://doi.org/10.1016/j.annemergmed.2013.07.024Samoff E, Waller A, Fleischauer A, et al. Integration of Syndromic Surveillance Data into Public Health Practice at State and Local Levels in North Carolina. Public Health Reports. 2012;127(3):310-317.Savard, N., Bédard, L., Allard, R., & Buckeridge, D.L. (2015). Using age, triage score, and disposition data from emergency department electronic records to improve Influenza-Like Illness surveillance. Journal of the American Medical Informatics Association, 22(3): 688-696. doi: 10.1093/jamia/ocu002Seil, K., Marcum, J., Lall, R., & Stayton, C. (2015). Utility of a near real-time emergency department syndromic surveillance system to track injuries in New York City. Injury Epidemiology, 2(1), 11. http://doi.org/10.1186/s40621-015-0044-5Smith, S., Elliot, A. J., Hajat, S., Bone, A., Smith, G. E., & Kovats, S. (2016). Estimating the burden of heat illness in England during the 2013 summer heatwave using syndromic surveillance. Journal of Epidemiology and Community Health, 70(5), 459–465. http://doi.org/10.1136/jech-2015-206079Stephens, E. (2017). Development of syndrome definitions for acute unintentional drug and heroin overdose. Online Journal of Public Health Informatics, (9)1. http://dx.doi.org/10.5210/ojphi.v9i1.7593.Stigi, K., Baer, A., Duchin, J., & Lofy, K. (2014). Evaluation of electronic ambulatory care data for Influenza-Like Illness surveillance, Washington state. 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Evaluating Real-Time Syndromic Surveillance Signals from Ambulatory Care Data in Four States. Public Health Reports. 2010;125(1):111-120.

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This paper presents basic theoretical knowledge of critical thinking. It describes characteristics of critical thinking, which are used for the formation of critical thinking indicators. These indicators are needed for assessing students’ critical thinking levels and for designing lessons to develop critical thinking competence for students. The paper articulates arguments for highlighting the necessity of critical thinking education for students in Vietnam. The paper contributes to knowledge base of critical thinking education and supports further studies on critical thinking in order to enhance the effectiveness of education in Vietnam. Key words Critical thinking, competence, education, students References Arend, B. (2009). Encouraging critical thinking in online threaded discussions. The Journal of Educators Online, 6(1), doi: 10.1.1.412.1694Bacon, F. (1605). The Advancement of Learning. Edited by Joseph Devey, M.A. (New York: P.F. Collier and Son, 1901).Bailin, S. (2002). Critical thinking and science education. Science & Education, Vol. 11, Issue 4, pp 362-375Bailin, S., Case, R., Coombs, J. R., & Daniels, L. B. (1999). Conceptualizing critical thinking. Journal of Curriculum Studies, 31(3), 285–302. Beyer, B. K. (1995). Critical thinking. Bloomington, IN: Phi Delta Kappa Educational Foundation. Biggs, J., 1996. Western misperceptions of the Confucian-heritage learning culture. In D. Watkins & J. Biggs (Eds.), The Chinese learner: Cultural, psychological and contextual influences (pp. 45 – 67). Hong Kong: The University of Hong Kong Comparative Education Research Centre.Bloom B. S. (1956). Taxonomy of Educational Objectives, Handbook I: The Cognitive Domain. New York: David McKay Co Inc. Bộ Giáo dục và Đào tạo (2018). Dự thảo Chương trình Giáo dục Phổ thông Tổng thể.Brookfield, S. D. (1987). Developing Critical Thinkers. Jossey-Bass, San FranciscoChan, S. (1999). The Chinese learning – A question of style. Education and Training, 41(6/7), 294-304.Dewey, J. (1916). Democracy and education: An introduction to the philosophy of education. New York: Macmillan. Đặng Tự Ân, 2015. Mô hình trường học mới Việt Nam nhìn từ góc độ thực tiễn và lí luận. NXB Giáo dục Việt NamĐỗ Đình Hoan (2002). Một số vấn đề cơ bản của chương trình tiểu học mới. NXB Giáo dục Việt NamEnnis, R. H. (1986). A concept of critical thinking. Havard Educational Review, 22(1): 81-111. Facione, P. A. (2011). Think Critically, Pearson Education: Englewood Cliffs, NJ.Garrison, D. R., Anderson, T., & Archer, W., (2000). Critical inquiry in a text-based environment: Computer conferencing in higher education. The internet and higher education, 2(2-3): 87-105Guyton, J. J. (1984). The effects of teaching cognitive strategies on problem solving skills of baccalaureate nursing students. (Doctoral dissertation, University of Toledo, OH, 1983). Dissertation Abstracts International. 44. 3587-A.Halpern, D. F. (2006). 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A content analysis method to measure critical thinking in face-to-face and computer supported group learning. Ipct - J, vol 3 (2), pp. 56-77.Nguyen Quang Kinh, Nguyen Quoc Chi (2008). Education in Vietnam: Development history, challenges and solutions. In An African Exploration of the East Asian Education Experience, Edited by Birger Fredriksen and Tan Jee Peng, The World Bank, Washington, D. C. Paul, R., & Elder, L. (2012). The nature and functions of critical & creative thinking. Tomales, CA: Foundation for Critical ThinkingRichmond, J. E. D. (2007). Bringing critical thinking to the education of developing country professionals, International Education Journal, v8 n1 p1-29 Ryan, J. & Louie, K. (2007). False dichotomy?: ‘Western’ and ‘Eastern’ concepts of scholarship and learning. Educational Philosophy and Theory (39)4, 404 - 417.Paul, R., & Scriven, M. (1987). 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Abstract: Nowadays, Vietnamese women are participating actively in parts of the economy that were previously deemed male domain. Women are involved in business activities at all levels in Vietnam, making significant contributions to the economic development of the country. By December 2011, there were 81,226 small and medium enterprises headed by women, accounting for 25% of the total number of enterprises in the country (GSO, 2013). In Vietnam, despite recent economic development, socio-cultural and legal barriers are still very difficult for women since the general perception in society is that a woman’s main duty is to be a good housewife and mother and they are also often perceived as weak, passive and irrational (VWEC, 2007). Even though the studies related to women entrepreneurship development are quite extensive, amongst them only a limited number of researches on the role of legal and socio - cultural barriers on women entrepreneurs in the context of Vietnam have been investigated. Thus, supported by the World Trade Institute (WTI) in Bern, Switzerland, the researchers have chosen this as the subject of this study. Based on a quantitative survey of 110 companies in Hanoi and adjacent areas, the research has taken legal and socio - cultural barriers and explored their effect on the development of women entrepreneurship in the context of Vietnam in order to indicate how women entrepreneurs perceive the impact of socio-cultural factors, economic impacts, and policy reforms on their entrepreneurial situations and initiatives, and to then provide policy implications for promoting women’s entrepreneurship and gender equality in Vietnam. Keywords Entrepreneurship, female entrepreneurs, gender equality, Vietnam References Acs, Z. & Varga, A. (2005) ‘Entrepreneurship, agglomeration and technological change’, Small Business Economics, 24, 323---334. Avin, R.M & Kinney, L.P (2014). Trends in Female Entrepreneurship in Vietnam Preliminary paper presented at the 23th Annual Conference on Feminist Economics sponsored by IAFFE, University of Ghana, Accra, Ghana, June 27-29, 2014.Avin, R.-M., & Kinney, L. P. (2014) ‘Trends in Women entrepreneurship in Vietnam’, 23rd Annual Conference on Feminist Economics, Ghana: 27 – 29 June.Bruton, G. D., Ahlstrom, D., & Obloj, K. (2008). Entrepreneurship in emerging economies: where are we today and where should the research go in the future. Entrepreneurship: Theory and Practice, 32(1), 1–14.Bunck, J. M. 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Vietnam: Food and Agricultural Organisation and United Nations Development Programme. Available at: http://www.fao.org/docrep/005/ac685e/ac685e00.htm [Accessed 7 December 2015].Fuentelsaz, L., González, C., Maícas, J., & Montero, J. (2015). ‘How different formal institutions affect opportunity and necessity entrepreneurship’. Business Research Quarterly, 18(4), 246-258. Gallup, J (2004) The wage labor market and inequality in Vietnam. In Economic growth, poverty, and household welfare in Vietnam edited by Paul Glewwe, Nisha Agrawal, and David Dollar. Washington, D.C.: The World Bank.General Statistics Office of Vietnam (GSO) (2014), Population and employment Report 2014Global Entrepreneurship Monitor. (2013). Vietnam report 2013. United Kingdom. Retrieved from: www.gemconsortium.orgHampel-Milagrosa, A., Pham, H., Nguyen, Q., and Nguyen, T. (2010) ‘Gender-Related Obstacles to Vietnamese Women Entrepreneurs’. Vietnam: United Nations Industrial Development Organisation and Vietnam Chamber of Commerce and Industry. Available at: http://www.un.org.vn/en/publications/publications-by-agency/doc_details/294-gender-related-obstacles-to-vietnamese-women-entrepreneurs. html [Accessed 7 December 2015].Hang, T.T.T. (2008), “Women’s leadership in Vietnam: opportunities and challenges”, Signs, Vol. 34 No. 1, pp. 16-21. Hirschman, C. and V. M. Loi (1996) Family and Household Structure in Vietnam: Some glimpses from a recent survey, Pacific Affairs Vol 69 (No. 2 (Summer 1996)): 229-249Hoang, B.T. (2010), “Rural employment and life: challenges to gender roles in Vietnam’s agriculture at present”, paper presented at the FAO-IFAD-ILO Workshop on Gaps, Trends and Current Research in Gender Dimensions of Agricultural and Rural Employment: Differentiated Pathways Out of Poverty Rome, 31 March-2 April 2009, available at: www.fao-ilo.org/fileadmin/user_upload/fao_ilo/pdf/Papers/16_march/Thinh_final.pdf Hoang, C., Hoang, C.L.T.S, Nguyen, T.P.C, Ngo, T.P.L, Tran, T.N, Vu, T.L (2013), The women’s access to land in contemporary Vietnam. UNDP Report 2013Hoskisson, R. E., Eden, L., Lau, C.M., &Wright, M. (2000). Strategy in emerging economies. Academy of Management Journal, 43(3), 249–267.ILO (2011) ‘Creation of an enabling environment for women entrepreneur in Vietnam: Mainstreaming gender issues in government policy on enterprise development’, Hanoi.International Finance Corporation (2006) A National Survey of Women Business Owners in Vietnam. 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Moldy core is a fungal disease of apple fruits that is characterized by mycelial growth in the seed locules and is sometimes accompanied by penetration of the immediate surrounding flesh. The disease can go undetected until the fruit is cut open, as no external symptoms appear on the fruit. Alternaria, Aspergillus, Cladosporium, Coniothyrium, Epicoccum, Phoma and Stemphylium are some of the common pathogens associated with moldy core (Serdani et al. 2002; Gao et al. 2013; McLeod 2014). The disease is more common in apple cultivars with an open calyx, where spores may initiate infections during the growing season or at the post-harvest storage stage (Spotts et al. 1988). In 2018, a shipment of ‘Sweet Tango’ apples from New Zealand to Scotian Gold Co-operative Ltd., Nova Scotia, Canada, was found to be affected by moldy core. Moderate to severe moldy core symptoms were observed when 10 apples were cut open (Figure S1). In comparison, ‘Sweet Tango’ apples grown in Nova Scotia showed no moldy core symptoms when 10 random fruits were cut open. Small pieces of the diseased fruit tissue from the core region were surface-disinfected for 1 min in 1% NaOCl, rinsed three times with sterilized water and placed onto potato dextrose agar (PDA) dishes. The PDA dishes were incubated in dark at 22 oC and single spore isolation was carried out to fresh PDA dishes. These isolate produced colonies of regular shape, tan black with prominent white gray margin and gray colour conidia (Figure S2 AB). The colonies turn dark black after 3 weeks of growth on PDA. Mycelia were septate and conidia were oval or obclavate or club-shaped with a tapering end with 4-6 longitudinal and transverse septa (Figure S2 C-D). The size of conidia ranges from 12.5-20 x 8.7-12.5 µM on 20 days old PDA dishes. Based on the size and shape of conidia and other morphological characteristics the isolated fungi were identical to Alternaria spp. (Simmons 2007). To assess the identity of the isolated pathogen species by multi-locus sequence analysis, genomic DNA was extracted from the pure cultures of two isolates (5.8 and 8) using the E.Z.N.A. SP Fungal DNA Kit (Omega Bio-Tek). The glyceraldehyde-3-phosphate dehydrogenase (GAPDH), major allergen (Alt a 1), OPA10-2, the internal transcribed spacer (ITS) region of ribosomal DNA and the translation elongation factor 1-α (TEF1-α) region from two Alternaria spp. isolates (5.8 and 8) were amplified and sequenced using primers gpd1/2 (Berbee et al. 1999), A21F/A21R (Gabriel 2015), OPA10-2/ OPA10-2L (Andrew et al. 2009), ITS1/ITS4 (White et al. 1990) and EF1-up /EF1-low (O’Donnell et al. 1998) respectively. The resulting sequences of both isolates were deposited in the NCBI GenBank (GAPDH; MW411052, MW411053, Alt a 1; MW411050, MW411051, OPA10-2; MW415762, MW415763, ITS; MK140445, MT225559, TEF1-α; MT305773 and MT305774 ). Sequences of GAPDH, Alt a 1, OPA-10-2, ITS and TEF1-α genes of both isolates were identical to each other and showed 100 %, 100 %, 99.21 %, 100% and 100% identity to A. arborescens S. (AY278810.1, AY563303.1, KP124712.1, KY965831.1, KY965831.1) respectively. Identity with reference strain CBS 102605 confirms that both of the isolated strains 5.8 and 8 are A. arborescens. The pathogenicity of the two A. arborescens isolates were confirmed by artificially inoculating healthy ‘Sweet Tango’ fruit by dispensing the conidial suspension directly on the seed locule. Briefly, surface-disinfected fruits were air-dried for 5 min and then peeled using a sterilized knife and cut transversally. Each half of the fruit was inoculated with 100 µl of conidial suspensions (∼1 × 104 conidia/ml) in potato dextrose broth (PDB) and incubated at 22 °C in a humid chamber for 7–10 days, or until symptoms with visible mycelial growth were observed. The control fruits were treated with 100 µl of sterilized PDB. Both A. arborescens isolates produced visible moldy core symptoms on the inoculated ‘Sweet Tango’ fruits, whereas no symptoms were observed on the control fruits (Figure S1). The experiment was repeated three times with at least three replicates with similar results. A. arborescens was successfully re-isolated from the artificially-inoculated fruits to complete Koch’s postulates. To our knowledge, this is the first report of Alternaria arborescens causing moldy core disease in ‘Sweet Tango’ apples from New Zealand. Acknowledgments We thank Eric Bevis for his help in sample preparation for DNA sequencing, Willy Renderos for pathogenicity assay. We also thank Joan Hebb (Scotian Gold Cooperative Ltd.,) for providing the apple sample for this study. This research was made possible through financial support from Agriculture and Agri-Food Canada. The authors(s) declare no conflict of interest. Literature Cited Andrew M., Peever T.L., Pryor B.M. An expanded multilocus phylogeny does not resolve species among the small-spored Alternaria species complex. 2009. Mycologia. 101:95–109. Berbee, M. L. et al. 1999. Cochliobolus phylogenetics and the origin of known, highly virulent pathogens, inferred from ITS and glyceraldehyde-3-phosphate dehydrogenase gene sequences Mycologia. 91:964. Gabriel, M.F. I. Postigo, A. Gutiérrez-Rodríguez, E. Suñén, C.T. Tomaz, J. Martínez 2015. Development of a PCR-based tool for detecting immunologically relevant Alt a 1 and Alt a 1 hom*ologue coding sequences. Medical Mycology. 53 (6):636–642. Gao, L. L., Zhang, Q., Sun, X. Y., Jiang, L., Zhang, R., Sun, G. Y., Zha, Y. L., and Biggs, A. R. 2013. Etiology of moldy core, core browning, and core rot of Fuji apple in China. Plant Dis. 97:510–516. Kerry, O’Donnell, H.C. Kistler, E. Cigelnik, R.C. Ploetz. 1998. Multiple evolutionary origins of the fungus causing Panama disease of banana: concordant evidence from nuclear and mitochondrial gene genealogies. PNAS. 95: 2044-2049. McLeod, A. 2014. Moldy core and core rots. Pages 40–41 in: Compendium of Apple and Pear Diseases and Pests, 2nd ed. T. B. Sutton, H. S. Aldwinckle, A. M. Agnello, and J. F. Walgenbach, eds. American Phytopathological Society, St Paul, MN. Serdani, M., Kang, J. C., Peever, T. L., Andersen, B., and Crous, P. W. 2002. Characterization of Alternaria species groups associated with core rot of apples in South Africa. Mycol. Res. 106:561–569. Simmons, E. G. 2007. Alternaria: an identification manual. CBS Biodiversity Series. 6:780 pp. Spotts, R. A., Holmes, R. J., and Washington, W. S. 1988. Factors affecting wet core rot of apples. Australas. Plant Pathol. 17:53–57. White, T. J., Bruns, T., Lee, S., and Taylor, J. 1990. Amplification and direct sequencing of fungal ribosomal RNA genes for phylogenetics. Pages 315–322 in: PCR Protocols: A Guide to Methods and Applications. M. A. Innis, D. H. Gelfand, J. J. Sninsky, and T. J. White, eds. San Diego, CA: Academic Press. Woudenberg, J. H. C., et al. 2015. Alternaria section Alternaria: Species, formae speciales or pathotypes. Stud. Mycol. 82:1-21.

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Today's universities are transforming into the entrepreneurial university model. Along with that is a strong innovation in governance towards autonomy and associated with entrepreneurship, innovation and creativity. The article presents research results on the model of the entrepreneurial university and the advanced university governance in terms of structure and management methods to adapt to this model in the world. Through the review of studies on the current situation, the article contributes a number of policy proposals to meet the requirements of university governance innovation for Vietnamese public universities in the context of transition to a model of entrepreneurial university. Keywords University, Entrepreneurial university, University governance, Vietnam public universities. References [1] D.V. Toan, 2020, Factors Affecting Third Mission Implementation and The Challenges for Vietnam’s Universities in The Transitioning Period. VNU Journal of Science: Economics and Business, 37(3) (2020) 75-84 (in Vietnamese), https://doi.org/10.25073/2588-1108/vnueab.4355.[2] A. Bramwell, D.A. Wolfe, Universities and regional economic development: the entrepreneurial University of Waterloo, Res. Policy 37(8) (2008) 1175-1187.[3] K. Yokoyama, Entrepreneurialism in Japanese and UK Universities: Governance, Management, Leadership and Funding, High Education 52 (2006) https://doi.org/10.1007/s10734-005-1168-2.[4] C. Shore, L. McLauchlan, Third mission’ activities, commercialisation and academic entrepreneurs, Social Anthropology/Anthropologie Sociale, 20 (3) (2012) 267-286. https://doi.org/10.1111/j.1469-8676.2012.00207.x.[5] H. Etzkowitz The norms of entrepreneurial science: cognitive effects of the new university - industry linkages, Research Policy, 27(8) (1998) 823-833.[6] H. Etzkowitz, L. Leydesdorff, The Dynamics of Innovation: From National Systems and ‘Mode 2’ to a Triple Helix of University - Industry - Government Relations, Research Policy, 29(2) (2000) 109-123.[7] L.B. Costa, A.L. Torkomian, Um Estudo Exploratório sobre um Novo Tipo de Empreendimento: os Spin-ffs Acadêmicos, Rev. Adm. Contemp. 12(2) (2008) 395-427.[8] J.J. Degroof, E.B. Roberts, Overcoming weak entrepreneurial infrastructures for academic spin-off ventures, J. Technol. Transf. 29(3–4) (2004) 327-352.[9] A. Vohora, M. Wright, A. Lockett, Critical junctures in the development of uni-versity high-tech spinout companies, Res. Policy 33(1) (2004) 147-175.[10] V. Revest, A. Sapio, Financing technology-based small firms in Europe: what do we know?, Small Bus. Econ. 39(1) (2010) 179-205.[11] E. Rasmussen, O.J. Borch, University capabilities in facilitating entrepreneurship: a longitudinal study of spin-off ventures at mid-range universities, Res. Policy 39(5) (2010) 602-612.[12] L. Aaboen, Explaining incubators using firm analogy, Technovation 29(10) (2009) 657-670.[13] M. Abreu, V. Grinevich, The nature of academic entrepreneurship in the UK: widening the focus on entrepreneurial activities, Res. Policy 42(2) (2013) 408-422.[14] E. Rasmussen, S. Mosey, M. Wright, The influence of university departments on the evolution of entrepreneurial competencies in spin-off ventures. Res. Policy 43(1) (2014) 92-106.[15] H. Etzkowitz, The Triple Helix: University-Industry-Government Innovation in Action, Taylor and Francis, London, 2008. [16] D.B. Audretsch, From the entrepreneurial university to the university for the en-trepreneurial society, J. Technol. Transfer. 39(3) (2014) 313–321.[17] B.R. Clark, Creating Entrepreneurial Universities: Organizational Pathways of Transformation, Issues in Higher Education, Elsevier, Oxford: IAU Press and Pergamon, New York 1998. [18] B. Sp*rn, Building Adaptive Universities: Emerging Organisational Forms Based on Experiences of European and US Universities, Education and Management, 7:2 (2001) 121-134. https://doi.org/10.1023/A:1011346201972.[19] H. Etzkowitz, Research group as ‘quasi-firm’? The invention of the entrepreneurial university. Res. Policy 32 (1) (2003) 109-121.[20] M. Guerrero, D. Kirby and D. Urbano, A Literature Review on Entrepreneurial Universities: An Institutional Approach, Working paper presented at the 3rd Conference of Pre-communications to Congresses, Autonomous University of Barcelona, June 2006.[21] F.T. Rothaermel, S.D. Agung and L. Jiang, University entrepreneurship: a taxonomy of the literature, Industrial and Corporate Change, 16(4) (2007) 691-791. https://doi.org/10.1093/icc/dtm023.[22] A. A. Gibb, G. Haskins & Robertson, Leading the entrepreneurial university, National Council for Graduate Entrepreneurship (NCGE). http://www.ncge.org.uk (accessed 10 November 2020). [23] M. Guerrero, D. Urbano, The development of an entrepreneurial university, The Journal of Technology Transfer 37(1) (2010) 43-74. DOI: 10.1007/s10961-010-9171-x.[24] L.K. Sooreh, Salamzadeh, A., Safarzadeh, H. Salamzadeh, Y., Defining and Measuring Entrepreneurial Universities: A Study in Iranian Context Using Importance-Performance Analysis and TOPSIS Technique, Global Business and Management Research: An International Journal, 3(2) (2011) 182-199. [25] J.Y. Farsi, N. Imanipour and A. Salamzadeh, Entrepreneurial university conceptualization: case of developing countries, Global Business and Management Research, 4(2) (2012) 193-204. [26] Y.C. Chang, P.Y. Yang, B.R. Martin, H.R. Chi, T.F. Tsai-Lin, Entrepreneurial universities and research ambidexterity: A multilevel analysis, Technovation 54 (2016) 7-21. http://dx.doi.org/10.1016/j.technovation.2016.02.006[27] G. Dalmarco, W. Hulsink, G.V. Blois, Creating entrepreneurial universities in an emerging economy: Evidencefrom Brazil, Technological Forecasting & Social Change 135 (2018) 99-111. doi:10.1016/j.techfore.2018.04.015.[28] S. Boffo, A. Cocorullo, University Fourth Mission: Spin-offs and Academic Entrenreneurship: Connecting Public Policies with new missions and management issues of universities, Higher Education Forum 16 (2019) 125-142.[29] D.V. Toan, Entrepreneurial Universities and the Development Model for Public Universities in Vietnam, International Journal of Entrepreneurship, 24(1) 2020 1-16. [30] J. Röpke, The Entrepreneurial University, Innovation, academic knowledge creation and regional development in a globalized economy, Working Paper Department of Economics, Philipps- Universität Marburg, Germany: 15, 1998[31] D.V. Toan, H.V. Hai, N.P. Mai, The Role of Entrepreneurship Development in Universities to Promote Knowledge Sharing: The Case of Vietnam National University Hanoi, Proceedings of Asia Pacific Conference on Information Management “Common Platform to A Sustainable Society In The Dynamic Asia Pacific”, VNU Press, Hanoi, October, 2016. [32] D.V. Toan, Development of enterprises in universities and policy implications for university governance reform in Vietnam VNU Journal of Science: Economics and Business, 35(1) (2019) 83-96 (in Vietnamese).[33] P. Zgaga, Higher Education in Transition - Reconsiderations on Higher Education in Europe at the Turn of Millennium, Monographs on Journal of Research in Teacher Education, Ed. Gun-Marie Frånberg, Publisher: Umeå University, 2007. ISBN: 978-91-7264-505-9.[34] J. Fielden, Global Trends in University Governance. Education Working Paper Series, number 9, World Bank, Washington, 2008.[35] A.H. Dooley, The role of academic boards in university governance, Policy paper formulated at the National Conference of Chairs of Academic Boards and Senates, The University of New South Wales, October 2005.[36] A. Lizzio, Student participation in university governance: the role conceptions and sense of efficacy of student representatives on departmental committees, Studies in Higher Education Journal, Taylor & Francis 34(1) (2009) 69-84. https://doi.org/10.1080/03075070802602000.[37] D.V. Toan, Development of Enterprises in Universities: From International Experience to Practices in Vietnam, Vietnam National University Press, Hanoi, 2019, 49-64 (in Vietnamese),.[38] D.V. Toan, H.T.C. Thuong, International experience in university governance and lessons for Vietnam, Economy and Forecast Review 20 (2020) 41-45. [39] D.V. Toan, Business development in universities: International experience and policy recomendation for Vietnam Economy and Forecast Review 35 (2018) 58-60 (in Vietnamese). [40] D.V. Toan, Entrepreneurship in public universities in Vietnam in the context of transition to autonomy (in Vietnamese), Economy and Forecast Review 30 (2019) 111-116.[41] D.V. Toan, University - Enterprise Cooperation in International Context and Implications for Vietnam (in Vietnamese), VNU Journal of Science: Economics and Business 32 (4) (2016) 32-44.

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IntroductionNew digital technologies hold promise for equalising access to information and communication for the Deaf community. SMS technology, for example, has helped to equalise deaf peoples’ access to information and made it easier to communicate with both deaf and hearing people (Tane Akamatsu et al.; Power and Power; Power, Power, and Horstmanshof; Valentine and Skelton, "Changing", "Umbilical"; Harper). A wealth of anecdotal evidence and some recent academic work suggests that new media technology is also reshaping deaf peoples’ sense of local and global community (Breivik "Deaf"; Breivik, Deaf; Brueggeman). One focus of research on new media technologies has been on technologies used for point to point communication, including communication (and interpretation) via video (Tane Akamatsu et al.; Power and Power; Power, Power, and Horstmanshof). Another has been the use of multimedia technologies in formal educational setting for pedagogical purposes, particularly English language literacy (e.g. Marshall Gentry et al.; Tane Akamatsu et al.; Vogel et al.). An emphasis on the role of multimedia in deaf education is understandable, considering the on-going highly politicised contest over whether to educate young deaf people in a bilingual environment using a signed language (Swanwick & Gregory). However, the increasing significance of social and participatory media in the leisure time of Westerners suggests that such uses of Web 2.0 are also worth exploring. There have begun to be some academic accounts of the enthusiastic adoption of vlogging by sign language users (e.g. Leigh; Cavander and Ladner) and this paper seeks to add to this important work. Web 2.0 has been defined by its ability to, in Denise Woods’ word, “harness collective intelligence” (19.2) by providing opportunities for users to make, adapt, “mash up” and share text, photos and video. As well as its well-documented participatory possibilities (Bruns), its re-emphasis on visual (as opposed to textual) communication is of particular interest for Deaf communities. It has been suggested that deaf people are a ‘visual variety of the human race’ (Bahan), and the visually rich presents new opportunities for visually rich forms of communication, most importantly via signed languages. The central importance of signed languages for Deaf identity suggests that the visual aspects of interactive multimedia might offer possibilities of maintenance, enhancement and shifts in those identities (Hyde, Power and Lloyd). At the same time, the visual aspects of the Web 2.0 are often audio-visual, such that the increasingly rich resources of the net offer potential barriers as well as routes to inclusion and community (see Woods; Ellis; Cavander and Ladner). In particular, lack of captioning or use of Auslan in video resources emerges as a key limit to the accessibility of the visual Web to deaf users (Cahill and Hollier). In this paper we ask to what extent contemporary digital media might create moments of permeability in what Krentz has called “the hearing line, that invisible boundary separating deaf and hearing people”( 2)”. To provide tentative answers to these questions, this paper will explore the use of participatory digital media by a group of young Deaf people taking part in a small-scale digital moviemaking project in Sydney in 2009. The ProjectAs a starting point, the interdisciplinary research team conducted a video-making course for young deaf sign language users within the Department of Media, Music and Cultural Studies at Macquarie University. The research team was comprised of one deaf and four hearing researchers, with expertise in media and cultural studies, information technology, sign language linguistics/ deaf studies, and signed language interpreting. The course was advertised through the newsletter of partner organization the NSW Deaf Society, via a Sydney bilingual deaf school and through the dense electronic networks of Australian deaf people. The course attracted fourteen participants from NSW, Western Australia and Queensland ranging in age from 10 to 18. Twelve of the participants were male, and two female. While there was no aspiration to gather a representative group of young people, it is worth noting there was some diversity within the group: for example, one participant was a wheelchair user while another had in recent years moved to Sydney from Africa and had learned Auslan relatively recently. Students were taught a variety of storytelling techniques and video-making skills, and set loose in groups to devise, shoot and edit a number of short films. The results were shared amongst the class, posted on a private YouTube channel and made into a DVD which was distributed to participants.The classes were largely taught in Auslan by a deaf teacher, although two sessions were taught by (non-deaf) members of Macquarie faculty, including an AFI award winning director. Those sessions were interpreted into Auslan by a sign language interpreter. Participants were then allowed free creative time to shoot video in locations of their choice on campus, or to edit their footage in the computer lab. Formal teaching sessions lasted half of each day – in the afternoons, participants were free to use the facilities or participate in a range of structured activities. Participants were also interviewed in groups, and individually, and their participation in the project was observed by researchers. Our research interest was in what deaf young people would choose to do with Web 2.0 technologies, and most particularly the visually rich elements of participatory and social media, in a relatively unstructured environment. Importantly, our focus was not on evaluating the effectiveness of multimedia for teaching deaf young people, or the level of literacy deployed by deaf young people in using the applications. Rather we were interested to discover the kinds of stories participants chose to tell, the ways they used Web 2.0 applications and the modalities of communication they chose to use. Given that Auslan was the language of instruction of the course, would participants draw on the tradition of deaf jokes and storytelling and narrate stories to camera in Auslan? Would they use the format of the “mash-up”, drawing on found footage or photographs? Would they make more filmic movies using Auslan dialogue? How would they use captions and text in their movies: as subtitles for Auslan dialogue? As an alternative to signing? Or not at all? Our observations from the project point to the great significance of the visual dimensions of Web 2.0 for the deaf young people who participated in the project. Initially, this was evident in the kind of movies students chose to make. Only one group – three young people in their late teens which included both of the young women in the class - chose to make a dialogue heavy movie, a spoof of Charlie’s Angels, entitled Deaf Angels. This movie included long scenes of the Angels using Auslan to chat together, receiving instruction from “Charlie” in sign language via videophone and recruiting “extras”, again using Auslan, to sign a petition for Auslan to be made an official Australian language. In follow up interviews, one of the students involved in making this film commented “my clip is about making a political statement, while the other [students in the class] made theirs just for fun”. The next group of (three) films, all with the involvement of the youngest class member, included signed storytelling of a sort readily recognisable from signed videos on-line: direct address to camera, with the teller narrating but also taking on the roles of characters and presenting their dialogue directly via the sign language convention of “role shift” - also referred to as constructed action and constructed dialogue (Metzger). One of these movies was an interesting hybrid. The first half of the four minute film had two young actors staging a hold-up at a vending machine, with a subsequent chase and fight scene. Like most of the films made by participants in the class, it included only one line of signed dialogue, with the rest of the narrative told visually through action. However, at the end of the action sequence, with the victim safely dead, the narrative was then retold by one of the performers within a signed story, using conventions typically observed in signed storytelling - such as role shift, characterisation and spatial mapping (Mather & Winston; Rayman; Wilson).The remaining films similarly drew on action and horror genres with copious use of chase and fight scenes and melodramatic and sometimes quite beautiful climactic death tableaux. The movies included a story about revenging the death of a brother; a story about escaping from jail; a short story about a hippo eating a vet; a similar short comprised of stills showing a sequence of executions in the computer lab; and a ghost story. Notably, most of these movies contained very little dialogue – with only one or two lines of signed dialogue in each four to five minute video (with the exception of the gun handshape used in context to represent the object liberally throughout most films). The kinds of movies made by this limited group of people on this one occasion are suggestive. While participants drew on a number of genres and communication strategies in their film making, the researchers were surprised at how few of the movies drew on traditions of signed storytelling or jokes– particularly since the course was targeted at deaf sign language users and promoted as presented in Auslan. Consequently, our group of students were largely drawn from the small number of deaf schools in which Auslan is the main language of instruction – an exceptional circ*mstance in an Australian setting in which most deaf young people attend mainstream schools (Byrnes et al.; Power and Hyde). Looking across the Hearing LineWe can make sense of the creative choices made by the participants in the course in a number of ways. Although methods of captioning were briefly introduced during the course, iMovie (the package which participants were using) has limited captioning functionality. Indeed, one student, who was involved in making the only clip to include captioning which contextualised the narrative, commented in follow-up interviews that he would have liked more information about captioning. It’s also possible that the compressed nature of the course prevented participants from undertaking the time-consuming task of scripting and entering captions. As well as being the most fun approach to the projects, the use of visual story telling was probably the easiest. This was perhaps exacerbated by the lack of emphasis on scriptwriting (outside of structural elements and broad narrative sweeps) in the course. Greater emphasis on that aspect of film-making would have given participants a stronger foundational literacy for caption-based projectsDespite these qualifications, both the movies made by students and our observations suggest the significance of a shared visual culture in the use of the Web by these particular young people. During an afternoon when many of the students were away swimming, one student stayed in the lab to use the computers. Rather than working on a video project, he spent time trawling through YouTube for clips purporting to show ghost sightings and other paranormal phenomena. He drew these clips to the attention of one of the research team who was present in the lab, prompting a discussion about the believability of the ghosts and supernatural apparitions in the clips. While some of the clips included (uncaptioned) off-screen dialogue and commentary, this didn’t seem to be a barrier to this student’s enjoyment. Like many other sub-genres of YouTube clips – pranks, pratfalls, cute or alarmingly dangerous incidents involving children and animals – these supernatural videos as a genre rely very little on commentary or dialogue for their meaning – just as with the action films that other students drew on so heavily in their movie making. In an E-Tech paper entitled "The Cute Cat Theory of Digital Activism", Ethan Zuckerman suggests that “web 1.0 was invented to allow physicists to share research papers and web 2.0 was created to allow people to share pictures of cute cats”. This comment points out both the Web 2.0’s vast repository of entertaining material in the ‘funny video’genre which is visually based, dialogue free, entertaining material accessible to a wide range of people, including deaf sign language users. In the realm of leisure, at least, the visually rich resources of Web 2.0’s ubiquitous images and video materials may be creating a shared culture in which the line between hearing and deaf people’s entertainment activities is less clear than it may have been in the past. The ironic tone of Zuckerman’s observation, however, alerts us to the limits of a reliance on language-free materials as a route to accessibility. The kinds of videos that the participants in the course chose to make speaks to the limitations as well as resources offered by the visual Web. There is still a limited range of captioned material on You Tube. In interviews, both young people and their teachers emphasised the central importance of access to captioned video on-line, with the young people we interviewed strongly favouring captioned video over the inclusion on-screen of simultaneous signed interpretations of text. One participant who was a regular user of a range of on-line social networking commented that if she really liked the look of a particular movie which was uncaptioned, she would sometimes contact its maker and ask them to add captions to it. Interestingly, two student participants emphasised in interviews that signed video should also include captions so hearing people could have access to signed narratives. These students seemed to be drawing on ideas about “reverse discrimination”, but their concern reflected the approach of many of the student movies - using shared visual conventions that made their movies available to the widest possible audience. All the students were anxious that hearing people could understand their work, perhaps a consequence of the course’s location in the University as an overwhelmingly hearing environment. In this emphasis on captioning rather than sign as a route to making media accessible, we may be seeing a consequence of the emphasis Krentz describes as ubiquitous in deaf education “the desire to make the differences between deaf and hearing people recede” (16). Krentz suggests that his concept of the ‘hearing line’ “must be perpetually retested and re-examined. It reveals complex and shifting relationships between physical difference, cultural fabrication and identity” (7). The students’ movies and attitudes emphasised the reality of that complexity. Our research project explored how some young Deaf people attempted to create stories capable of crossing categories of deafness and ‘hearing-ness’… unstable (like other identity categories) while others constructed narratives that affirmed Deaf Culture or drew on the Deaf storytelling traditions. This is of particular interest in the Web 2.0 environment, given that its technologies are often lauded as having the politics of participation. The example of the Deaf Community asks reasonable questions about the validity of those claims, and it’s hard to escape the conclusion that there is still less than appropriate access and that some users are more equal than others.How do young people handle the continuing lack of material available to the on the Web? The answer repeatedly offered by our young male interviewees was ‘I can’t be bothered’. As distinct from “I can’t understand” or “I won’t go there” this answer, represented a disengagement from demands to identify your literacy levels, reveal your preferred means of communication; to rehearse arguments about questions of access or expose attempts to struggle to make sense of texts that fail to employ readily accessible means of communicating. Neither an admission of failure or a demand for change, CAN’T-BE-BOTHERED in this context offers a cool way out of an accessibility impasse. This easily-dismissed comment in interviews was confirmed in a whole-group discussions, when students came to a consensus that if when searching for video resources on the Net they found video that included neither signing nor captions, they would move on to find other more accessible resources. Even here, though, the ground continues to shift. YouTube recently announced that it was making its auto-captioning feature open to everybody - a machine generated system that whilst not perfect does attempt to make all YouTube videos accessible to deaf people. (Bertolucci).The importance of captioning of non-signed video is thrown into further significance by our observation from the course of the use of YouTube as a search engine by the participants. Many of the students when asked to research information on the Web bypassed text-based search engines and used the more visual results presented on YouTube directly. In research on deaf adolescents’ search strategies on the Internet, Smith points to the promise of graphical interfaces for deaf young people as a strategy for overcoming the English literacy difficulties experienced by many deaf young people (527). In the years since Smith’s research was undertaken, the graphical and audiovisual resources available on the Web have exploded and users are increasingly turning to these resources in their searches, providing new possibilities for Deaf users (see for instance Schonfeld; Fajardo et al.). Preliminary ConclusionsA number of recent writers have pointed out the ways that the internet has made everyday communication with government services, businesses, workmates and friends immeasurably easier for deaf people (Power, Power and Horstmanshof; Keating and Mirus; Valentine and Skelton, "Changing", "Umbilical"). The ready availability of information in a textual and graphical form on the Web, and ready access to direct contact with others on the move via SMS, has worked against what has been described as deaf peoples’ “information deprivation”, while everyday tasks – booking tickets, for example – are no longer a struggle to communicate face-to-face with hearing people (Valentine and Skelton, "Changing"; Bakken 169-70).The impacts of new technologies should not be seen in simple terms, however. Valentine and Skelton summarise: “the Internet is not producing either just positive or just negative outcomes for D/deaf people but rather is generating a complex set of paradoxical effects for different users” (Valentine and Skelton, "Umbilical" 12). They note, for example, that the ability, via text-based on-line social media to interact with other people on-line regardless of geographic location, hearing status or facility with sign language has been highly valued by some of their deaf respondents. They comment, however, that the fact that many deaf people, using the Internet, can “pass” minimises the need for hearing people in a phonocentric society to be aware of the diversity of ways communication can take place. They note, for example, that “few mainstream Websites demonstrate awareness of D/deaf peoples’ information and communication needs/preferences (eg. by incorporating sign language video clips)” ("Changing" 11). As such, many deaf people have an enhanced ability to interact with a range of others, but in a mode favoured by the dominant culture, a culture which is thus unchallenged by exposure to alternative strategies of communication. Our research, preliminary as it is, suggests a somewhat different take on these complex questions. The visually driven, image-rich approach taken to movie making, Web-searching and information sharing by our participants suggests the emergence of a certain kind of on-line culture which seems likely to be shared by deaf and hearing young people. However where Valentine and Skelton suggest deaf people, in order to participate on-line, are obliged to do so, on the terms of the hearing majority, the increasingly visual nature of Web 2.0 suggests that the terrain may be shifting – even if there is still some way to go.AcknowledgementsWe would like to thank Natalie Kull and Meg Stewart for their research assistance on this project, and participants in the course and members of the project’s steering group for their generosity with their time and ideas.ReferencesBahan, B. "Upon the Formation of a Visual Variety of the Human Race. In H-Dirksen L. Baumann (ed.), Open Your Eyes: Deaf Studies Talking. London: University of Minnesota Press, 2007.Bakken, F. “SMS Use among Deaf Teens and Young Adults in Norway.” In R. Harper, L. Palen, and A. Taylor (eds.), The Inside Text: Social, Cultural and Design Perspectives on SMS. Netherlands: Springe, 2005. 161-74. Berners-Lee, Tim. Weaving the Web. London: Orion Business, 1999.Bertolucci, Jeff. “YouTube Offers Auto-Captioning to All Users.” PC World 5 Mar. 2010. 5 Mar. 2010 < http://www.macworld.com/article/146879/2010/03/YouTube_captions.html >.Breivik, Jan Kare. Deaf Identities in the Making: Local Lives, Transnational Connections. Washington, D.C.: Gallaudet University Press, 2005.———. “Deaf Identities: Visible Culture, Hidden Dilemmas and Scattered Belonging.” In H.G. Sicakkan and Y.G. Lithman (eds.), What Happens When a Society Is Diverse: Exploring Multidimensional Identities. Lewiston, New York: Edwin Mellen Press, 2006. 75-104.Brueggemann, B.J. (ed.). Literacy and Deaf People’s Cultural and Contextual Perspectives. Washington, DC: Gaudellet University Press, 2004. Bruns, Axel. Blogs, Wikipedia, Second Life and Beyond: From Production to Produsage. New York: Peter Lang, 2008.Byrnes, Linda, Jeff Sigafoos, Field Rickards, and P. Margaret Brown. “Inclusion of Students Who Are Deaf or Hard of Hearing in Government Schools in New South Wales, Australia: Development and Implementation of a Policy.” Journal of Deaf Studies and Deaf Education 7.3 (2002): 244-257.Cahill, Martin, and Scott Hollier. Social Media Accessibility Review 1.0. Media Access Australia, 2009. Cavender, Anna, and Richard Ladner. “Hearing Impairments.” In S. Harper and Y. Yesilada (eds.), Web Accessibility. London: Springer, 2008.Ellis, Katie. “A Purposeful Rebuilding: YouTube, Representation, Accessibility and the Socio-Political Space of Disability." Telecommunications Journal of Australia 60.2 (2010): 1.1-21.12.Fajardo, Inmaculada, Elena Parra, and Jose J. Canas. “Do Sign Language Videos Improve Web Navigation for Deaf Signer Users?” Journal of Deaf Studies and Deaf Education 15.3 (2009): 242-262.Harper, Phil. “Networking the Deaf Nation.” Australian Journal of Communication 30.3 (2003): 153-166.Hyde, M., D. Power, and K. Lloyd. "W(h)ither the Deaf Community? Comments on Trevor Johnston’s Population, Genetics and the Future of Australian Sign Language." Sign Language Studies 6.2 (2006): 190-201. Keating, Elizabeth, and Gene Mirus. “American Sign Language in Virtual Space: Interactions between Deaf Users of Computer-Mediated Video.” Language in Society 32.5 (Nov. 2003): 693-714.Krentz, Christopher. Writing Deafness: The Hearing Line in Nineteenth-Century Literature. Chapel Hill, NC: University of North Carolina Press, 2007.Leigh, Irene. A Lens on Deaf Identities. Oxford: Oxford UP. 2009.Marshall Gentry, M., K.M. Chinn, and R.D. Moulton. “Effectiveness of Multimedia Reading Materials When Used with Children Who Are Deaf.” American Annals of the Deaf 5 (2004): 394-403.Mather, S., and E. Winston. "Spatial Mapping and Involvement in ASL Storytelling." In C. Lucas (ed.), Pinky Extension and Eye Gaze: Language Use in Deaf Communities. Washington, DC: Gallaudet University Press, 1998. 170-82.Metzger, M. "Constructed Action and Constructed Dialogue in American Sign Language." In C. Lucas (ed.), Sociolinguistics in Deaf Communities. Washington, DC: Gallaudet University Press, 1995. 255-71.Power, Des, and G. Leigh. "Principles and Practices of Literacy Development for Deaf Learners: A Historical Overview." Journal of Deaf Studies and Deaf Education 5.1 (2000): 3-8.Power, Des, and Merv Hyde. “The Characteristics and Extent of Participation of Deaf and Hard-of-Hearing Students in Regular Classes in Australian Schools.” Journal of Deaf Studies and Deaf Education 7.4 (2002): 302-311.Power, M., and D. Power “Everyone Here Speaks TXT: Deaf People Using SMS in Australia and the Rest of the World.” Journal of Deaf Studies and Deaf Education 9.3 (2004). Power, M., D. Power, and L. Horstmanshof. “Deaf People Communicating via SMS, TTY, Relay Service, Fax, and Computers in Australia.” Journal of Deaf Studies and Deaf Education 12.1 (2007): 80-92. Rayman, J. "Storytelling in the Visual Mode: A Comparison of ASL and English." In E. Wilson (ed.), Storytelling & Conversation: Discourse in Deaf Communities. Washington, DC: Gallaudet University Press, 2002. 59-82.Schonfeld, Eric. "ComScore: YouTube Now 25 Percent of All Google Searches." Tech Crunch 18 Dec. 2008. 14 May 2009 < http://www.techcrunch.com/2008/12/18/comscore-YouTube-now-25-percent-of-all-google-searches/?rss >.Smith, Chad. “Where Is It? How Deaf Adolescents Complete Fact-Based Internet Search Tasks." American Annals of the Deaf 151.5 (2005-6).Swanwick, R., and S. Gregory (eds.). Sign Bilingual Education: Policy and Practice. Coleford: Douglas McLean Publishing, 2007.Tane Akamatsu, C., C. Mayer, and C. Farrelly. “An Investigation of Two-Way Text Messaging Use with Deaf Students at the Secondary Level.” Journal of Deaf Studies and Deaf Education 11.1 (2006): 120-131.Valentine, Gill, and Tracy Skelton. “Changing Spaces: The Role of the Internet in Shaping Deaf Geographies.” Social and Cultural Geography 9.5 (2008): 469-85.———. “‘An Umbilical Cord to the World’: The Role of the Internet in D/deaf People’s Information and Communication Practices." Information, Communication and Society 12.1 (2009): 44-65.Vogel, Jennifer, Clint Bowers, Cricket Meehan, Raegan Hoeft, and Kristy Bradley. “Virtual Reality for Life Skills Education: Program Evaluation.” Deafness and Education International 61 (2004): 39-47.Wilson, J. "The Tobacco Story: Narrative Structure in an ASL Story." In C. Lucas (ed.), Multicultural Aspects of Sociolinguistics in Deaf Communities. Washington, DC: Gallaudet University Press, 1996. 152-80.Winston (ed.). Storytelling and Conversation: Discourse in Deaf Communities. Washington, D.C: Gallaudet University Press. 59-82.Woods, Denise. “Communicating in Virtual Worlds through an Accessible Web 2.0 Solution." Telecommunications Journal of Australia 60.2 (2010): 19.1-19.16YouTube Most Viewed. Online video. YouTube 2009. 23 May 2009 < http://www.YouTube.com/browse?s=mp&t=a >.

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Abstract:

Photo by Sharon McCutcheon on Unsplash ABSTRACT COVID-19 highlighted a disproportionate impact upon marginalized communities that needs to be addressed. Specifically, a focus on equity rather than equality would better address and prevent the disparities seen in COVID-19. A distributive justice framework can provide this great benefit but will succeed only if the medical community engages in outreach, anti-racism measures, and listens to communities in need. INTRODUCTION COVID-19 disproportionately impacted communities of color and lower socioeconomic status, sparking political discussion about existing inequities in the US.[1] Some states amended their guidelines for allocating resources, including vaccines, to provide care for marginalized communities experiencing these inequities, but there has been no clear consensus on which guidelines states should amend or how they should be ethically grounded. In part, this is because traditional justice theories do not acknowledge the deep-seated institutional and interpersonal discrimination embedded in our medical system. Therefore, a revamped distributive justice approach that accounts for these shortcomings is needed to guide healthcare decision-making now and into the post-COVID era. BACKGROUND Three terms – health disparity, health inequities, and health equity – help frame the issue. A health disparity is defined as any difference between populations in terms of disease incidence or adverse health events, such as morbidity or mortality. In contrast, health inequities are health disparities due to avoidable systematic structures rooted in racial, social, and economic injustice.[2] For example, current data demonstrate that Black, Latino, Indigenous Americans, and those living in poverty suffer higher morbidity and mortality rates from COVID-19.[3] Finally, health equity is the opportunity for anyone to attain his or her full health potential without interference from systematic structures and factors that generate health inequities, including race, socioeconomic status, gender, ethnicity, religion, sexual orientation, or geography.[4] ANALYSIS Health inequities for people of color with COVID-19 have led to critiques of states that do not account for race in their resource allocation guidelines.[5] For example, the Massachusetts Department of Public Health revised its COVID-19 guidelines regarding resource allocation to patients with the best chance of short-term survival.[6] Critics have argued that this change addresses neither preexisting structural inequities nor provider bias that may have led to comorbidities and increased vulnerability to COVID-19. By failing to address race specifically, they argue the policy will perpetuate poorer outcomes in already marginalized groups. As the inequities in COVID-19 outcomes continue to be uncovered and the data continue to prove that marginalized communities suffered disproportionately, we, as healthcare providers, must reconsider our role in addressing the injustices. Our actions must be ethically grounded in the concept of justice. l. Primary Theories of Justice The principle of justice in medical ethics relates to how we ought to treat people and allocate resources. Multiple theories have emerged to explain how justice should be implemented, with three of the most prominent being egalitarianism, utilitarianism, and distributive. This paper argues that distributive justice is the best framework for remedying past actions and enacting systemic changes that may persistently prevent injustices. An egalitarian approach to justice states all individuals are equal and, therefore, should have identical access to resources. In the allocation of resources, an egalitarian approach would support a strict distribution of equal value regardless of one’s attributes or characteristics. Putting this theory into practice would place a premium on guidelines based upon first-come, first-served basis or random selection.[7] However, the egalitarian approach taken in the UK continues to worsen health inequities due to institutional and structural discrimination.[8] A utilitarian approach to justice emphasizes maximizing overall benefits and achieving the greatest good for the greatest number of people. When resources are limited, the utilitarian principle historically guides decision-making. In contrast to the egalitarian focus on equal distribution, utilitarianism focuses on managing distributions to maximize numerical outcomes. During the COVID-19 pandemic, guidelines for allocating resources had utilitarian goals like saving the most lives, which may prioritize the youthful and those deemed productive in society, followed by the elderly and the very ill. It is important to reconsider using utilitarian approaches as the default in the post-COVID healthcare community. These approaches fail to address past inequity, sacrificing the marginalized in their emphasis on the greatest amount of good rather than the type of good. Finally, a distributive approach to justice mandates resources should be allocated in a manner that does not infringe individual liberties to those with the greatest need. Proposed by John Rawls in a Theory of Justice, this approach requires accounting for societal inequality, a factor absent from egalitarianism and utilitarianism.[9] Naomi Zack elaborates how distributive justice can be applied to healthcare, outlining why racism is a social determinant of health that must be acknowledged and addressed.[10] Until there are parallel health opportunities and better alignment of outcomes among different social and racial groups, the underlying systemic social and economic variables that are driving the disparities must be fixed. As a society and as healthcare providers, we should be striving to address the factors that perpetuate health inequities. While genetics and other variables influence health, the data show proportionately more exposure, more cases, and more deaths in the Black American and Hispanic populations. Preexisting conditions and general health disparities are signs of health inequity that increased vulnerability. Distributive justice as a theoretical and applied framework can be applied to preventable conditions that increase vulnerability and can justify systemic changes to prevent further bias in the medical community. During a pandemic, egalitarian and utilitarian approaches to justice are prioritized by policymakers and health systems. Yet, as COVID-19 has demonstrated, they further perpetuate the death and morbidity of populations that face discrimination. These outcomes are due to policies and guidelines that overall benefit white communities over communities of color. Historically, US policy that looks to distribute resources equally (focusing on equal access instead of outcomes), in a color-blind manner, has further perpetuated poor outcomes for marginalized communities.[11] ll. Historical and Ongoing Disparities Across socio-demographic groups, the medical system exacerbates historical and current inequities. Members of marginalized races,[12] women,[13] LGBTQ people,[14] and poor people[15] experience trauma caused by discrimination, marginalization, and failure to access high-quality public and private goods. Through the unequal treatment of marginalized communities, these historic traumas continue. In the US, people of color do not receive equal and fair medical treatment. A meta-analysis found that Hispanics and Black Americans were significantly undertreated for pain compared to their white counterparts over the last 20 years.[16] This is partly due to provider bias. Through interviewing medical trainees, a study by the National Academy of Science found that half of medical students and residents harbored racist beliefs such as “Black people’s nerve endings are less sensitive than white people’s” or “Black people’s skin is thicker than white people’s skin.”[17] More than 3,000 Indigenous American women were coerced, threatened, and deliberately misinformed to ensure cooperation in forced sterilization.[18] Hispanic people have less support in seeking medical care, in receiving culturally appropriate care, and they suffer from the medical community’s lack of resources to address language barriers.[19] In the US, patients of different sexes do not receive the same quality of healthcare. Despite having greater health needs, middle-aged and older women are more likely to have fewer hospital stays and fewer physician visits compared to men of similar demographics and health risk profiles.[20] In the field of critical care, women are less likely to be admitted to the ICU, less likely to receive interventions such as mechanical ventilation, and more likely to die compared to their male ICU counterparts.[21] In the US, patients of different socioeconomic statuses do not receive the same quality of healthcare. Low-income patients are more likely to have higher rates of infant mortality, chronic disease, and a shorter life span.[22] This is partly due to the insurance-based discrimination in the medical community.[23] One in three deaths of those experiencing homelessness could have been prevented by timely and effective medical care. An individual experiencing homelessness has a life expectancy that is decades shorter than that of the average American.[24] lll. Action Needed: Policy Reform While steps need to be taken to provide equitable care in the current pandemic, including the allocation of vaccines, they may not address the historical failures of health policy, hospital policy, and clinical care to eliminate bias and ensure equal treatment of patients. According to an applied distributive justice framework, inequities must be corrected. Rather than focusing primarily on fair resource allocation, medicine must be actively anti-racist, anti-sexist, anti-transphobic, and anti-discriminatory. Evidence has shown that the health inequities caused by COVID-19 are smaller in regions that have addressed racial wealth gaps through forms of reparations.[25] Distributive justice calls for making up for the past using tools of allocation as well as tools to remedy persistent problems. For example, Brigham and Women’s Hospital in Boston, MA, began “Healing ARC,” a pilot initiative that involves acknowledgement, redress, and closure on an institutional level.[26] Acknowledgement entails informing patients about disparities at the hospital, claiming responsibility, and incorporating community ideas for redress. Redress involves a preferential admission option for Black and Hispanic patients to specialty services, especially cardiovascular services, rather than general medicine. Closure requires that community and patient stakeholders work together to ensure that a new system is in place that will continue to prioritize equity. Of note, redress could take the form of cash transfers, discounted or free care, taxes on nonprofit hospitals that exclude patients of color,[27] or race-explicit protocol changes (such as those being instituted by Brigham and Women’s Hospital that admit patients historically denied access to certain forms of medical care). In New York, for instance, the New York State Bar Association drafted the COVID-19 resolutions to ensure that emergency regulations and guidelines do not discriminate against communities of color, and even mandate that diverse patient populations be included in clinical trials.[28] Also, physicians must listen to individuals from marginalized communities to identify needs and ensure that community members take part in decision-making. The solution is not to simply build new health centers in communities of color, as this may lead to tiers of care. Rather, local communities should have a chance to impact existing hospital policy and should also use their political participation to further their healthcare interests. Distributive justice does not seek to disenfranchise groups that hold power in the system. It aims to transform the system so that those in power do not continue to obtain unfair benefits at the expense of others. The framework accounts for unjust historical oppression and current injustices in our system to provide equitable outcomes to all who access the system. In this vein, we can begin to address the flagrant disparities between communities that have always – and continue to – exist in healthcare today.[29] CONCLUSION As equality focuses on access, it currently fails to do justice. Instead of outcomes, it is time to focus on equity. A focus on equity rather than equality would better address and prevent the disparities seen in COVID-19. A distributive justice framework can gain traction in clinical decision-making guidelines and system-level reallocation of resources but will succeed only if the medical community engages in outreach, anti-racism measures, and listens to communities in need. There should be an emphasis on implementing a distributive justice framework that treats all patients equitably, accounts for historical harm, and focuses on transparency in allocation and public health decision-making. [1] APM Research Lab Staff. 2020. “The Color of Coronavirus: COVID-19 Deaths by Race and Ethnicity in the U.S.” APM Research Lab. https://www.apmresearchlab.org/covid/deaths-by-race. [2] Bharmal, N., K. P. Derose, M. Felician, and M. M. Weden. 2015. “Understanding the Upstream Social Determinants of Health.” California: RAND Corporation 1-18. https://www.rand.org/pubs/working_papers/WR1096.html. [3] Yancy, C. W. 2020. “COVID-19 and African Americans.” JAMA. 323 (19): 1891-2. https://doi.org/10.1001/jama.2020.6548; Centers for Disease Control and Prevention. 2020. “COVID-19 in Racial and Ethnic Health Disparities.” Centers for Disease Control and Prevention. https://www.cdc.gov/coronavirus/2019-ncov/community/health-equity/racial-ethnic-disparities/index.html. 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